Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus
Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocke...
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1979
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v56_n1-2_p61_Borda http://hdl.handle.net/20.500.12110/paper_00142999_v56_n1-2_p61_Borda |
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paper:paper_00142999_v56_n1-2_p61_Borda2023-06-08T14:36:53Z Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus alpha adrenergic receptor beta adrenergic receptor butoxamine isoprenaline noradrenalin phentolamine phentolamine mesylate phenylephrine practolol progesterone propranolol soterenol animal experiment blood and hemopoietic system dose response drug comparison drug interaction drug response estrogen blood level female genital system in vitro study pregnancy progesterone blood level rat uterus contractility uterus contraction Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocked by butoxamine. The affinity of myometrium for the β2-adrenoceptor agonist was parallel to the concentration of progesterone in plasma during pregnancy. Isoproterenol, norepinephrine and phenylephrine caused dual, α- and β-mediated responses; their relative dominance varied with the concentration and the days of pregnancy. α-Adrenoceptor effects of the amines coincided with increased plasma concentrations of estrogens, whereas β ones were in parallel with the increment of plasma progesterone. It is concluded that: there exist in the pregnant rat uterus β2-receptor-mediated responses influenced by the length of gestation; and the concentration-pregnancy-dependent biphasic actions of isoproterenol, norepinephrine or phenylephrine suggest that their variable hormone-modulated ability interacts with both α- and β-adrenoceptive uterine sites. 1979 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v56_n1-2_p61_Borda http://hdl.handle.net/20.500.12110/paper_00142999_v56_n1-2_p61_Borda |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
alpha adrenergic receptor beta adrenergic receptor butoxamine isoprenaline noradrenalin phentolamine phentolamine mesylate phenylephrine practolol progesterone propranolol soterenol animal experiment blood and hemopoietic system dose response drug comparison drug interaction drug response estrogen blood level female genital system in vitro study pregnancy progesterone blood level rat uterus contractility uterus contraction |
| spellingShingle |
alpha adrenergic receptor beta adrenergic receptor butoxamine isoprenaline noradrenalin phentolamine phentolamine mesylate phenylephrine practolol progesterone propranolol soterenol animal experiment blood and hemopoietic system dose response drug comparison drug interaction drug response estrogen blood level female genital system in vitro study pregnancy progesterone blood level rat uterus contractility uterus contraction Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| topic_facet |
alpha adrenergic receptor beta adrenergic receptor butoxamine isoprenaline noradrenalin phentolamine phentolamine mesylate phenylephrine practolol progesterone propranolol soterenol animal experiment blood and hemopoietic system dose response drug comparison drug interaction drug response estrogen blood level female genital system in vitro study pregnancy progesterone blood level rat uterus contractility uterus contraction |
| description |
Cumulative log dose-response curves of soterenol, isoproterenol, phenylephrine and norepinephrine on isolated pregnant rat uterus at different days of gestation, were investigated. Soterenol produced a sustained inhibition of spontaneous motility during the whole pregnancy and this effect was blocked by butoxamine. The affinity of myometrium for the β2-adrenoceptor agonist was parallel to the concentration of progesterone in plasma during pregnancy. Isoproterenol, norepinephrine and phenylephrine caused dual, α- and β-mediated responses; their relative dominance varied with the concentration and the days of pregnancy. α-Adrenoceptor effects of the amines coincided with increased plasma concentrations of estrogens, whereas β ones were in parallel with the increment of plasma progesterone. It is concluded that: there exist in the pregnant rat uterus β2-receptor-mediated responses influenced by the length of gestation; and the concentration-pregnancy-dependent biphasic actions of isoproterenol, norepinephrine or phenylephrine suggest that their variable hormone-modulated ability interacts with both α- and β-adrenoceptive uterine sites. |
| title |
Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| title_short |
Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| title_full |
Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| title_fullStr |
Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| title_full_unstemmed |
Adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| title_sort |
adrenoceptors involved in the contractile activity of isolated pregnant rat uterus |
| publishDate |
1979 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00142999_v56_n1-2_p61_Borda http://hdl.handle.net/20.500.12110/paper_00142999_v56_n1-2_p61_Borda |
| _version_ |
1768545676617056256 |