Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages
There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubert...
Guardado en:
| Publicado: |
2006
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v147_n3_p1556_Franca http://hdl.handle.net/20.500.12110/paper_00137227_v147_n3_p1556_Franca |
| Aporte de: |
| id |
paper:paper_00137227_v147_n3_p1556_Franca |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00137227_v147_n3_p1556_Franca2023-06-08T14:36:12Z Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages corticosterone follitropin glutamate sodium leptin luteinizing hormone testosterone animal experiment animal model animal tissue article body weight cell proliferation corticosterone blood level data analysis female follitropin blood level free thyroxine index genetics hormone blood level hyperleptinemia hypothalamus hypophysis system Leydig cell luteinizing hormone blood level male measurement newborn nonhuman obesity phenotype prepuberty priority journal prolactin blood level rat reproduction Sertoli cell testis testis function testis weight testosterone blood level Adipose Tissue Animals Animals, Newborn Cell Nucleus Cell Proliferation Corticosterone Female Follicle Stimulating Hormone Leptin Leydig Cells Male Mice Phenotype Prolactin Rats Rats, Sprague-Dawley Seminiferous Tubules Sertoli Cells Testis Testosterone Thyroxine Time Factors There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, testosterone (T), corticosterone, and free T4 (FT4) were measured. MSG rats displayed elevated circulating levels of corticosterone and hyperadiposity/ hyperleptinemia, regardless of the age examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal MSG rats revealed a significant (P < 0.05) reduction in testis weight and the number of Sertoli (SC) and Leydig cells per testis. Leptin plasma levels were severalfold higher (2.41 vs. 8.07; P < 0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T, and FT4 levels significantly decreased (P < 0.05). Taken together, these data indicate that testis development, as well as SC and Leydig cell proliferation, were disturbed in prepubertal MSG rats. Adult MSG rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04; P < 0.05) and lower (P < 0.05) LH and FSH plasma levels. However, T and FT4 plasma levels were normal, and no apparent alterations were observed in testis structure of MSG rats. Only the number of SCs per testis was significantly (P < 0.05) reduced in the adult MSG rats. In conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably responsible for the reproductive axis damages in MSG animals, it remains to be investigated whether this condition is the main factor for hypothalamus-pituitary-gonadal axis dysfunction in MSG rats. Copyright © 2006 by The Endocrine Society. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v147_n3_p1556_Franca http://hdl.handle.net/20.500.12110/paper_00137227_v147_n3_p1556_Franca |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
corticosterone follitropin glutamate sodium leptin luteinizing hormone testosterone animal experiment animal model animal tissue article body weight cell proliferation corticosterone blood level data analysis female follitropin blood level free thyroxine index genetics hormone blood level hyperleptinemia hypothalamus hypophysis system Leydig cell luteinizing hormone blood level male measurement newborn nonhuman obesity phenotype prepuberty priority journal prolactin blood level rat reproduction Sertoli cell testis testis function testis weight testosterone blood level Adipose Tissue Animals Animals, Newborn Cell Nucleus Cell Proliferation Corticosterone Female Follicle Stimulating Hormone Leptin Leydig Cells Male Mice Phenotype Prolactin Rats Rats, Sprague-Dawley Seminiferous Tubules Sertoli Cells Testis Testosterone Thyroxine Time Factors |
| spellingShingle |
corticosterone follitropin glutamate sodium leptin luteinizing hormone testosterone animal experiment animal model animal tissue article body weight cell proliferation corticosterone blood level data analysis female follitropin blood level free thyroxine index genetics hormone blood level hyperleptinemia hypothalamus hypophysis system Leydig cell luteinizing hormone blood level male measurement newborn nonhuman obesity phenotype prepuberty priority journal prolactin blood level rat reproduction Sertoli cell testis testis function testis weight testosterone blood level Adipose Tissue Animals Animals, Newborn Cell Nucleus Cell Proliferation Corticosterone Female Follicle Stimulating Hormone Leptin Leydig Cells Male Mice Phenotype Prolactin Rats Rats, Sprague-Dawley Seminiferous Tubules Sertoli Cells Testis Testosterone Thyroxine Time Factors Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| topic_facet |
corticosterone follitropin glutamate sodium leptin luteinizing hormone testosterone animal experiment animal model animal tissue article body weight cell proliferation corticosterone blood level data analysis female follitropin blood level free thyroxine index genetics hormone blood level hyperleptinemia hypothalamus hypophysis system Leydig cell luteinizing hormone blood level male measurement newborn nonhuman obesity phenotype prepuberty priority journal prolactin blood level rat reproduction Sertoli cell testis testis function testis weight testosterone blood level Adipose Tissue Animals Animals, Newborn Cell Nucleus Cell Proliferation Corticosterone Female Follicle Stimulating Hormone Leptin Leydig Cells Male Mice Phenotype Prolactin Rats Rats, Sprague-Dawley Seminiferous Tubules Sertoli Cells Testis Testosterone Thyroxine Time Factors |
| description |
There are few data for hormonal levels and testis structure and function during postnatal development in rats neonatally treated with monosodium L-glutamate (MSG). In our study, newborn male pups were ip injected with MSG (4 mg/g body weight) every 2 d up to 10 d of age and investigated at prepubertal and adult ages. Plasma levels of leptin, LH, FSH, prolactin, testosterone (T), corticosterone, and free T4 (FT4) were measured. MSG rats displayed elevated circulating levels of corticosterone and hyperadiposity/ hyperleptinemia, regardless of the age examined; conversely, circulating prolactin levels were not affected. Moreover, prepubertal MSG rats revealed a significant (P < 0.05) reduction in testis weight and the number of Sertoli (SC) and Leydig cells per testis. Leptin plasma levels were severalfold higher (2.41 vs. 8.07; P < 0.05) in prepubertal MSG rats, and these animals displayed plasma LH, FSH, T, and FT4 levels significantly decreased (P < 0.05). Taken together, these data indicate that testis development, as well as SC and Leydig cell proliferation, were disturbed in prepubertal MSG rats. Adult MSG rats also displayed significantly higher leptin plasma levels (7.26 vs. 27.04; P < 0.05) and lower (P < 0.05) LH and FSH plasma levels. However, T and FT4 plasma levels were normal, and no apparent alterations were observed in testis structure of MSG rats. Only the number of SCs per testis was significantly (P < 0.05) reduced in the adult MSG rats. In conclusion, although early installed hyperadipose/hyperleptinemia phenotype was probably responsible for the reproductive axis damages in MSG animals, it remains to be investigated whether this condition is the main factor for hypothalamus-pituitary-gonadal axis dysfunction in MSG rats. Copyright © 2006 by The Endocrine Society. |
| title |
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| title_short |
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| title_full |
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| title_fullStr |
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| title_full_unstemmed |
Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| title_sort |
testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00137227_v147_n3_p1556_Franca http://hdl.handle.net/20.500.12110/paper_00137227_v147_n3_p1556_Franca |
| _version_ |
1768546522135265280 |