Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation
The viscosity of supercooled glycerol aqueous solutions, with glycerol mass fractions between 0.70 and 0.90, have been determined to confirm that the Avramov-Milchev equation describes very well the temperature dependence of the viscosity of the binary mixtures including the supercooled regime. On t...
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2012
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paper:paper_00112240_v65_n2_p159_TrejoGonzalez2023-06-08T14:34:50Z Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation Longinotti, Maria Paula Corti, Horacio Roberto Diffusion Glassy state Glycerol aqueous solutions Supercooled Viscosity glycerol water aqueous solution article Avramov Milchev equation controlled study cooling cryopreservation deterioration diffusion lifespan low temperature mathematical analysis model molecule priority journal Stokes Einstein equation supercooling temperature dependence validity viscosity Cold Temperature Cryopreservation Cryoprotective Agents Diffusion Glycerol Models, Chemical Solutions Viscosity Water The viscosity of supercooled glycerol aqueous solutions, with glycerol mass fractions between 0.70 and 0.90, have been determined to confirm that the Avramov-Milchev equation describes very well the temperature dependence of the viscosity of the binary mixtures including the supercooled regime. On the contrary, it is shown that the free volume model of viscosity, with the parameters proposed in a recent work (He, Fowler, Toner, J. Appl. Phys. 100 (2006) 074702), overestimates the viscosity of the glycerol-rich mixtures at low temperatures by several orders of magnitude. Moreover, the free volume model for the water diffusion leads to predictions of the Stokes-Einstein product, which are incompatible with the experimental findings. We conclude that the use of these free volume models, with parameters obtained by fitting experimental data far from the supercooled and glassy regions, lead to incorrect predictions of the deterioration rates of biomolecules, overestimating their life times in these cryopreservation media. © 2012 Elsevier Inc. Fil:Paula Longinotti, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Corti, H.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v65_n2_p159_TrejoGonzalez http://hdl.handle.net/20.500.12110/paper_00112240_v65_n2_p159_TrejoGonzalez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Diffusion Glassy state Glycerol aqueous solutions Supercooled Viscosity glycerol water aqueous solution article Avramov Milchev equation controlled study cooling cryopreservation deterioration diffusion lifespan low temperature mathematical analysis model molecule priority journal Stokes Einstein equation supercooling temperature dependence validity viscosity Cold Temperature Cryopreservation Cryoprotective Agents Diffusion Glycerol Models, Chemical Solutions Viscosity Water |
| spellingShingle |
Diffusion Glassy state Glycerol aqueous solutions Supercooled Viscosity glycerol water aqueous solution article Avramov Milchev equation controlled study cooling cryopreservation deterioration diffusion lifespan low temperature mathematical analysis model molecule priority journal Stokes Einstein equation supercooling temperature dependence validity viscosity Cold Temperature Cryopreservation Cryoprotective Agents Diffusion Glycerol Models, Chemical Solutions Viscosity Water Longinotti, Maria Paula Corti, Horacio Roberto Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| topic_facet |
Diffusion Glassy state Glycerol aqueous solutions Supercooled Viscosity glycerol water aqueous solution article Avramov Milchev equation controlled study cooling cryopreservation deterioration diffusion lifespan low temperature mathematical analysis model molecule priority journal Stokes Einstein equation supercooling temperature dependence validity viscosity Cold Temperature Cryopreservation Cryoprotective Agents Diffusion Glycerol Models, Chemical Solutions Viscosity Water |
| description |
The viscosity of supercooled glycerol aqueous solutions, with glycerol mass fractions between 0.70 and 0.90, have been determined to confirm that the Avramov-Milchev equation describes very well the temperature dependence of the viscosity of the binary mixtures including the supercooled regime. On the contrary, it is shown that the free volume model of viscosity, with the parameters proposed in a recent work (He, Fowler, Toner, J. Appl. Phys. 100 (2006) 074702), overestimates the viscosity of the glycerol-rich mixtures at low temperatures by several orders of magnitude. Moreover, the free volume model for the water diffusion leads to predictions of the Stokes-Einstein product, which are incompatible with the experimental findings. We conclude that the use of these free volume models, with parameters obtained by fitting experimental data far from the supercooled and glassy regions, lead to incorrect predictions of the deterioration rates of biomolecules, overestimating their life times in these cryopreservation media. © 2012 Elsevier Inc. |
| author |
Longinotti, Maria Paula Corti, Horacio Roberto |
| author_facet |
Longinotti, Maria Paula Corti, Horacio Roberto |
| author_sort |
Longinotti, Maria Paula |
| title |
Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| title_short |
Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| title_full |
Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| title_fullStr |
Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| title_full_unstemmed |
Viscosity of supercooled aqueous glycerol solutions, validity of the Stokes-Einstein relationship, and implications for cryopreservation |
| title_sort |
viscosity of supercooled aqueous glycerol solutions, validity of the stokes-einstein relationship, and implications for cryopreservation |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00112240_v65_n2_p159_TrejoGonzalez http://hdl.handle.net/20.500.12110/paper_00112240_v65_n2_p159_TrejoGonzalez |
| work_keys_str_mv |
AT longinottimariapaula viscosityofsupercooledaqueousglycerolsolutionsvalidityofthestokeseinsteinrelationshipandimplicationsforcryopreservation AT cortihoracioroberto viscosityofsupercooledaqueousglycerolsolutionsvalidityofthestokeseinsteinrelationshipandimplicationsforcryopreservation |
| _version_ |
1768546003104825344 |