The β1 adrenergic effects of antibodies against the C-terminal end of the ribosomal P2β protein of Trypanosoma cruzi associate with a specific pattern of epitope recognition

BALB/c mice immunized with recombinant Trypanosoma cruzi ribosomal P2β protein (TcP2β) develop a strong and specific antibody response against its 13 residue-long C-terminal epitope (peptide R13: EEEDDDMGFGLFD) that has a concomitant β1-adrenergic stimulating activity. However, other animals that un...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado: 2005
Materias:
β1-adrenergic receptor
Pathogenic antibodies
Ribosomal P proteins
Trypanosoma cruzi
beta 1 adrenergic receptor
epitope
glutamylglutamylglutamylaspartylaspartylaspartylmethionylglycylphenylalanylglycylleucylphenylalanylaspartic acid
peptide
protein antibody
protein TcP2beta
protozoal protein
ribosome protein
unclassified drug
autoantibody
immunoglobulin G
protozoon antibody
recombinant protein
adrenergic activity
amino acid sequence
animal experiment
animal model
antigen recognition
article
carboxy terminal sequence
controlled study
electrocardiography
epitope mapping
immune response
immunization
immunological tolerance
mouse
nonhuman
priority journal
protein analysis
protein motif
supraventricular tachycardia
animal
autoimmunity
Bagg albino mouse
Chagas disease
immunology
methodology
pathophysiology
Animals
Antibodies, Protozoan
Autoantibodies
Autoimmunity
Chagas Disease
Electrocardiography
Epitope Mapping
Epitopes
Immunoglobulin G
Mice
Mice, Inbred BALB C
Protozoan Proteins
Receptors, Adrenergic, beta-1
Recombinant Proteins
Ribosomal Proteins
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00099104_v142_n1_p140_Bergami
http://hdl.handle.net/20.500.12110/paper_00099104_v142_n1_p140_Bergami
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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