Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1

The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Since a late step of virus multiplication is hindered by 6b, we performed studies of drug-drug comb...

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Autores principales: Talarico, Laura Beatriz, Castilla, Viviana, Ramirez, Javier Alberto, Wachsman, Mónica Beatriz
Publicado: 2005
Materias:
(22S,23S)-3β-bromo- 5α,22,23-trihydroxystigmastan-6-one
Antiviral drug-drug combinations
Brassinosteroid derivatives
Herpes simplex
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
aciclovir
antivirus agent
foscarnet
unclassified drug
antiviral activity
article
controlled study
DNA sequence
drug activity
drug potentiation
gene frequency
gene mutation
gene targeting
Herpes simplex virus
nonhuman
priority journal
protein phosphorylation
virogenesis
Acyclovir
Animals
Antiviral Agents
Cell Line
Cell Proliferation
Cercopithecus aethiops
Cholestanones
Drug Synergism
Foscarnet
Herpesvirus 1, Human
Molecular Structure
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v52_n1_p38_Talarico
http://hdl.handle.net/20.500.12110/paper_00093157_v52_n1_p38_Talarico
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00093157_v52_n1_p38_Talarico
record_format dspace
spelling paper:paper_00093157_v52_n1_p38_Talarico2023-06-08T14:34:00Z Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1 Talarico, Laura Beatriz Castilla, Viviana Ramirez, Javier Alberto Wachsman, Mónica Beatriz (22S,23S)-3β-bromo- 5α,22,23-trihydroxystigmastan-6-one Antiviral drug-drug combinations Brassinosteroid derivatives Herpes simplex 3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one aciclovir antivirus agent foscarnet unclassified drug antiviral activity article controlled study DNA sequence drug activity drug potentiation gene frequency gene mutation gene targeting Herpes simplex virus nonhuman priority journal protein phosphorylation virogenesis Acyclovir Animals Antiviral Agents Cell Line Cell Proliferation Cercopithecus aethiops Cholestanones Drug Synergism Foscarnet Herpesvirus 1, Human Molecular Structure The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Since a late step of virus multiplication is hindered by 6b, we performed studies of drug-drug combination with acyclovir (ACV) and foscarnet (FOS). It was determined that 6b would act synergistically with low concentrations of ACV and moderate concentrations of FOS against HSV. The best drug combination tested in this study resulted in an increase of 29.3 and 47.2% in antiviral activity for ACV (0.036 μM) and FOS (37.5 μM) in the presence of 14.8 and 6.9 μM of 6b, respectively. Copyright © 2006 S. Karger AG. Fil:Talarico, L.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Castilla, V. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ramirez, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Wachsman, M.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v52_n1_p38_Talarico http://hdl.handle.net/20.500.12110/paper_00093157_v52_n1_p38_Talarico
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic (22S,23S)-3β-bromo- 5α,22,23-trihydroxystigmastan-6-one
Antiviral drug-drug combinations
Brassinosteroid derivatives
Herpes simplex
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
aciclovir
antivirus agent
foscarnet
unclassified drug
antiviral activity
article
controlled study
DNA sequence
drug activity
drug potentiation
gene frequency
gene mutation
gene targeting
Herpes simplex virus
nonhuman
priority journal
protein phosphorylation
virogenesis
Acyclovir
Animals
Antiviral Agents
Cell Line
Cell Proliferation
Cercopithecus aethiops
Cholestanones
Drug Synergism
Foscarnet
Herpesvirus 1, Human
Molecular Structure
spellingShingle (22S,23S)-3β-bromo- 5α,22,23-trihydroxystigmastan-6-one
Antiviral drug-drug combinations
Brassinosteroid derivatives
Herpes simplex
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
aciclovir
antivirus agent
foscarnet
unclassified drug
antiviral activity
article
controlled study
DNA sequence
drug activity
drug potentiation
gene frequency
gene mutation
gene targeting
Herpes simplex virus
nonhuman
priority journal
protein phosphorylation
virogenesis
Acyclovir
Animals
Antiviral Agents
Cell Line
Cell Proliferation
Cercopithecus aethiops
Cholestanones
Drug Synergism
Foscarnet
Herpesvirus 1, Human
Molecular Structure
Talarico, Laura Beatriz
Castilla, Viviana
Ramirez, Javier Alberto
Wachsman, Mónica Beatriz
Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
topic_facet (22S,23S)-3β-bromo- 5α,22,23-trihydroxystigmastan-6-one
Antiviral drug-drug combinations
Brassinosteroid derivatives
Herpes simplex
3beta bromo 5alpha,22,23 trihydroxystigmastan 6 one
aciclovir
antivirus agent
foscarnet
unclassified drug
antiviral activity
article
controlled study
DNA sequence
drug activity
drug potentiation
gene frequency
gene mutation
gene targeting
Herpes simplex virus
nonhuman
priority journal
protein phosphorylation
virogenesis
Acyclovir
Animals
Antiviral Agents
Cell Line
Cell Proliferation
Cercopithecus aethiops
Cholestanones
Drug Synergism
Foscarnet
Herpesvirus 1, Human
Molecular Structure
description The replication of herpes simplex virus (HSV) type 1 in Vero cells is inhibited in the presence of (22S,23S)-3β-bromo-5α,22,23- trihydroxystigmastan-6-one (6b), a synthetic brassinosteroid derivative. Since a late step of virus multiplication is hindered by 6b, we performed studies of drug-drug combination with acyclovir (ACV) and foscarnet (FOS). It was determined that 6b would act synergistically with low concentrations of ACV and moderate concentrations of FOS against HSV. The best drug combination tested in this study resulted in an increase of 29.3 and 47.2% in antiviral activity for ACV (0.036 μM) and FOS (37.5 μM) in the presence of 14.8 and 6.9 μM of 6b, respectively. Copyright © 2006 S. Karger AG.
author Talarico, Laura Beatriz
Castilla, Viviana
Ramirez, Javier Alberto
Wachsman, Mónica Beatriz
author_facet Talarico, Laura Beatriz
Castilla, Viviana
Ramirez, Javier Alberto
Wachsman, Mónica Beatriz
author_sort Talarico, Laura Beatriz
title Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
title_short Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
title_full Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
title_fullStr Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
title_full_unstemmed Synergistic in vitro interactions between (22S,23S)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
title_sort synergistic in vitro interactions between (22s,23s)-3β-bromo-5α, 22,23-trihydroxystigmastan-6-one and acyclovir or foscarnet against herpes simplex virus type 1
publishDate 2005
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00093157_v52_n1_p38_Talarico
http://hdl.handle.net/20.500.12110/paper_00093157_v52_n1_p38_Talarico
work_keys_str_mv AT talaricolaurabeatriz synergisticinvitrointeractionsbetween22s23s3bbromo5a2223trihydroxystigmastan6oneandacyclovirorfoscarnetagainstherpessimplexvirustype1
AT castillaviviana synergisticinvitrointeractionsbetween22s23s3bbromo5a2223trihydroxystigmastan6oneandacyclovirorfoscarnetagainstherpessimplexvirustype1
AT ramirezjavieralberto synergisticinvitrointeractionsbetween22s23s3bbromo5a2223trihydroxystigmastan6oneandacyclovirorfoscarnetagainstherpessimplexvirustype1
AT wachsmanmonicabeatriz synergisticinvitrointeractionsbetween22s23s3bbromo5a2223trihydroxystigmastan6oneandacyclovirorfoscarnetagainstherpessimplexvirustype1
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