Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris)
The expansion and intensification of agriculture during the past 50 years is unprecedented, and thus environmental problems have been triggered at different scales. These transformations have caused the loss of habitat and biodiversity, and disruption of the structure and functioning of ecosystems....
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2016
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092797_v244_n_p64_Siroski http://hdl.handle.net/20.500.12110/paper_00092797_v244_n_p64_Siroski |
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paper:paper_00092797_v244_n_p64_Siroski2023-06-08T14:33:58Z Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) Poletta, Gisela Laura Mudry, Marta Dolores Broad snouted caiman Complement system Glyphosate Immunotoxicity White blood cell glyphosate herbicide lipopolysaccharide glycine glyphosate herbicide lipopolysaccharide animal experiment Article biodiversity caiman Caiman latirostris complement system controlled study crocodilian degradation ecosystem environmental exposure Escherichia coli geographic distribution habitat immune response immune system immunity immunotoxicity innate immunity leukocyte leukocyte count lymphocyte nonhuman wildlife analogs and derivatives animal dose response drug effects immunology structure activity relation Alligators and Crocodiles Animals Dose-Response Relationship, Drug Escherichia coli Glycine Herbicides Leukocytes Lipopolysaccharides Structure-Activity Relationship The expansion and intensification of agriculture during the past 50 years is unprecedented, and thus environmental problems have been triggered at different scales. These transformations have caused the loss of habitat and biodiversity, and disruption of the structure and functioning of ecosystems. As a result of the expansion of the agricultural frontier in the recent past, many areas of the natural geographic distribution of the local wildlife, among them crocodilians and particularly the broad snouted caiman (Caiman latirostris), are being exposed to contaminants. The present study was designed to evaluate the effect of commercially-mixed glyphosate (RU) on some parameters of the immune system of C. latirostris. Two groups of caimans were exposed for two months to different concentrations of RU recommended for its application in the field, while one group was maintained as an unexposed control. The RU concentration was progressively decreased through the exposure period to simulate glyphosate degradation in water. After exposure, total and differential white blood cell (WBC), and complement system activity (CS) were determined. In addition, the animals were injected with a solution of lipopolysaccharide (LPS) from Escherichia coli to trigger an immune response and evaluate the parameters associated with it. The results showed that an effect of the herbicide on CS was observed, as animals exposed to RU showed a lower CS activity than animals from the negative control (NC) but not in total WBC. In the case of leukocyte population counts, differences were only found for heterophils and lymphocytes. © 2015 Published by Elsevier Ireland Ltd. Fil:Poletta, G.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mudry, M.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2016 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092797_v244_n_p64_Siroski http://hdl.handle.net/20.500.12110/paper_00092797_v244_n_p64_Siroski |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Broad snouted caiman Complement system Glyphosate Immunotoxicity White blood cell glyphosate herbicide lipopolysaccharide glycine glyphosate herbicide lipopolysaccharide animal experiment Article biodiversity caiman Caiman latirostris complement system controlled study crocodilian degradation ecosystem environmental exposure Escherichia coli geographic distribution habitat immune response immune system immunity immunotoxicity innate immunity leukocyte leukocyte count lymphocyte nonhuman wildlife analogs and derivatives animal dose response drug effects immunology structure activity relation Alligators and Crocodiles Animals Dose-Response Relationship, Drug Escherichia coli Glycine Herbicides Leukocytes Lipopolysaccharides Structure-Activity Relationship |
| spellingShingle |
Broad snouted caiman Complement system Glyphosate Immunotoxicity White blood cell glyphosate herbicide lipopolysaccharide glycine glyphosate herbicide lipopolysaccharide animal experiment Article biodiversity caiman Caiman latirostris complement system controlled study crocodilian degradation ecosystem environmental exposure Escherichia coli geographic distribution habitat immune response immune system immunity immunotoxicity innate immunity leukocyte leukocyte count lymphocyte nonhuman wildlife analogs and derivatives animal dose response drug effects immunology structure activity relation Alligators and Crocodiles Animals Dose-Response Relationship, Drug Escherichia coli Glycine Herbicides Leukocytes Lipopolysaccharides Structure-Activity Relationship Poletta, Gisela Laura Mudry, Marta Dolores Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| topic_facet |
Broad snouted caiman Complement system Glyphosate Immunotoxicity White blood cell glyphosate herbicide lipopolysaccharide glycine glyphosate herbicide lipopolysaccharide animal experiment Article biodiversity caiman Caiman latirostris complement system controlled study crocodilian degradation ecosystem environmental exposure Escherichia coli geographic distribution habitat immune response immune system immunity immunotoxicity innate immunity leukocyte leukocyte count lymphocyte nonhuman wildlife analogs and derivatives animal dose response drug effects immunology structure activity relation Alligators and Crocodiles Animals Dose-Response Relationship, Drug Escherichia coli Glycine Herbicides Leukocytes Lipopolysaccharides Structure-Activity Relationship |
| description |
The expansion and intensification of agriculture during the past 50 years is unprecedented, and thus environmental problems have been triggered at different scales. These transformations have caused the loss of habitat and biodiversity, and disruption of the structure and functioning of ecosystems. As a result of the expansion of the agricultural frontier in the recent past, many areas of the natural geographic distribution of the local wildlife, among them crocodilians and particularly the broad snouted caiman (Caiman latirostris), are being exposed to contaminants. The present study was designed to evaluate the effect of commercially-mixed glyphosate (RU) on some parameters of the immune system of C. latirostris. Two groups of caimans were exposed for two months to different concentrations of RU recommended for its application in the field, while one group was maintained as an unexposed control. The RU concentration was progressively decreased through the exposure period to simulate glyphosate degradation in water. After exposure, total and differential white blood cell (WBC), and complement system activity (CS) were determined. In addition, the animals were injected with a solution of lipopolysaccharide (LPS) from Escherichia coli to trigger an immune response and evaluate the parameters associated with it. The results showed that an effect of the herbicide on CS was observed, as animals exposed to RU showed a lower CS activity than animals from the negative control (NC) but not in total WBC. In the case of leukocyte population counts, differences were only found for heterophils and lymphocytes. © 2015 Published by Elsevier Ireland Ltd. |
| author |
Poletta, Gisela Laura Mudry, Marta Dolores |
| author_facet |
Poletta, Gisela Laura Mudry, Marta Dolores |
| author_sort |
Poletta, Gisela Laura |
| title |
Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| title_short |
Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| title_full |
Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| title_fullStr |
Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| title_full_unstemmed |
Immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (Caiman latirostris) |
| title_sort |
immunotoxicity of commercial-mixed glyphosate in broad snouted caiman (caiman latirostris) |
| publishDate |
2016 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00092797_v244_n_p64_Siroski http://hdl.handle.net/20.500.12110/paper_00092797_v244_n_p64_Siroski |
| work_keys_str_mv |
AT polettagiselalaura immunotoxicityofcommercialmixedglyphosateinbroadsnoutedcaimancaimanlatirostris AT mudrymartadolores immunotoxicityofcommercialmixedglyphosateinbroadsnoutedcaimancaimanlatirostris |
| _version_ |
1768543591781629952 |