Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release

A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some d...

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Autores principales: Prado, Héctor Juan, Matulewicz, María Cristina, Bonelli, Pablo R., Cukierman, Ana Lea
Publicado: 2009
Materias:
Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Dissolution
Starch
Turbidity
Controlled drug delivery
buffer
ibuprofen
polyelectrolyte
starch
article
controlled drug release
diffusion
dissolution
drug delivery system
drug synthesis
infrared spectroscopy
measurement
performance
pH
priority journal
tablet
tablet matrix
turbidity
Amylose
Carbohydrate Sequence
Carrageenan
Diffusion
Drug Carriers
Electrolytes
Pharmaceutical Preparations
Quaternary Ammonium Compounds
Spectroscopy, Fourier Transform Infrared
Tablets
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v344_n11_p1325_Prado
http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00086215_v344_n11_p1325_Prado
record_format dspace
spelling paper:paper_00086215_v344_n11_p1325_Prado2023-06-08T14:32:56Z Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release Prado, Héctor Juan Matulewicz, María Cristina Bonelli, Pablo R. Cukierman, Ana Lea Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Cationized starch Controlled release Ibuprofen Interpolyelectrolyte complex Kappa-carrageenan Matrix system Dissolution Starch Turbidity Controlled drug delivery buffer ibuprofen polyelectrolyte starch article controlled drug release diffusion dissolution drug delivery system drug synthesis infrared spectroscopy measurement performance pH priority journal tablet tablet matrix turbidity Amylose Carbohydrate Sequence Carrageenan Diffusion Drug Carriers Electrolytes Ibuprofen Pharmaceutical Preparations Quaternary Ammonium Compounds Spectroscopy, Fourier Transform Infrared Starch Tablets A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. © 2009 Elsevier Ltd. All rights reserved. Fil:Prado, H.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Matulewicz, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bonelli, P.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cukierman, A.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v344_n11_p1325_Prado http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Dissolution
Starch
Turbidity
Controlled drug delivery
buffer
ibuprofen
polyelectrolyte
starch
article
controlled drug release
diffusion
dissolution
drug delivery system
drug synthesis
infrared spectroscopy
measurement
performance
pH
priority journal
tablet
tablet matrix
turbidity
Amylose
Carbohydrate Sequence
Carrageenan
Diffusion
Drug Carriers
Electrolytes
Ibuprofen
Pharmaceutical Preparations
Quaternary Ammonium Compounds
Spectroscopy, Fourier Transform Infrared
Starch
Tablets
spellingShingle Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Dissolution
Starch
Turbidity
Controlled drug delivery
buffer
ibuprofen
polyelectrolyte
starch
article
controlled drug release
diffusion
dissolution
drug delivery system
drug synthesis
infrared spectroscopy
measurement
performance
pH
priority journal
tablet
tablet matrix
turbidity
Amylose
Carbohydrate Sequence
Carrageenan
Diffusion
Drug Carriers
Electrolytes
Ibuprofen
Pharmaceutical Preparations
Quaternary Ammonium Compounds
Spectroscopy, Fourier Transform Infrared
Starch
Tablets
Prado, Héctor Juan
Matulewicz, María Cristina
Bonelli, Pablo R.
Cukierman, Ana Lea
Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
topic_facet Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Cationized starch
Controlled release
Ibuprofen
Interpolyelectrolyte complex
Kappa-carrageenan
Matrix system
Dissolution
Starch
Turbidity
Controlled drug delivery
buffer
ibuprofen
polyelectrolyte
starch
article
controlled drug release
diffusion
dissolution
drug delivery system
drug synthesis
infrared spectroscopy
measurement
performance
pH
priority journal
tablet
tablet matrix
turbidity
Amylose
Carbohydrate Sequence
Carrageenan
Diffusion
Drug Carriers
Electrolytes
Ibuprofen
Pharmaceutical Preparations
Quaternary Ammonium Compounds
Spectroscopy, Fourier Transform Infrared
Starch
Tablets
description A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of tablets obtained by direct compression was independent of pH, and a maximum value of 742% was attained after 24 h. The performance of the IPEC as matrix for controlled release of ibuprofen indicates that drug delivery takes place in a zero-order manner. Experimental dissolution data in the buffer stage were properly represented by a model accounting for contributions of Fickian diffusion and relaxation phenomena; this model suggests that the former predominates over the latter, for the modeled range. © 2009 Elsevier Ltd. All rights reserved.
author Prado, Héctor Juan
Matulewicz, María Cristina
Bonelli, Pablo R.
Cukierman, Ana Lea
author_facet Prado, Héctor Juan
Matulewicz, María Cristina
Bonelli, Pablo R.
Cukierman, Ana Lea
author_sort Prado, Héctor Juan
title Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_short Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_full Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_fullStr Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_full_unstemmed Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
title_sort preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release
publishDate 2009
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v344_n11_p1325_Prado
http://hdl.handle.net/20.500.12110/paper_00086215_v344_n11_p1325_Prado
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AT bonellipablor preparationandcharacterizationofanovelstarchbasedinterpolyelectrolytecomplexasmatrixforcontrolleddrugrelease
AT cukiermananalea preparationandcharacterizationofanovelstarchbasedinterpolyelectrolytecomplexasmatrixforcontrolleddrugrelease
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