Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum
The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. α-L-Fucose was the major component but other sugars like β-D-galactose...
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2001
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v333_n4_p281_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v333_n4_p281_Duarte |
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paper:paper_00086215_v333_n4_p281_Duarte2023-06-08T14:32:40Z Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum Brown seaweed Chemical structure Fucans Fucoidans Sargassum stenophyllum Sulfated heteropolysaccharides Organic acids Polysaccharides Sugars Fucoidans Carbohydrates alpha glucose alpha glucuronic acid alpha levo fucose beta galactose beta xylose chondroitin sulfate fucoidin fucose galactose glucose glucuronic acid mannose sulfur derivative unclassified drug xylose article biosynthesis drug structure echinoderm fucosylation nonhuman priority journal seaweed structure analysis Anticoagulants Blood Coagulation Humans Monosaccharides Nuclear Magnetic Resonance, Biomolecular Optical Rotation Partial Thromboplastin Time Polysaccharides Seaweed Thrombin Time algae Cucumis sativus Holothuroidea Sargassum stenophyllum The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. α-L-Fucose was the major component but other sugars like β-D-galactose, β-D-mannose, α-D-glucuronic acid, α-D-glucose and β-D-xylose were also in substantial amounts. Fucoidans from the other set contain small amounts of α-D-glucuronic acid and high percentages of sulfate groups, which are concentrated on the fucose residues, with only fucose and galactose as major components. Structural studies of one fucoidan from each set suggest that these products have a general basic structure that has a formal resemblance to that of the fucosylated chondroitin sulfates from the body wall of sea cucumbers, namely, a linear core (formed mainly by (1→6)-β-D-galactose and/or (1→2)-β-D-mannose units) with branched chains of 'fucans' (formed by (1→3) and/or (1→4)-α-L-fucose, (1→4)-α-D-glucuronic acid, terminal β-D-xylose and, sometimes, (1→4)-α-D-glucose). In fucoidans from the second set, the 'core' is reduced to short galactan chains. © 2001 Elsevier Science Ltd. All rights reserved. 2001 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v333_n4_p281_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v333_n4_p281_Duarte |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Brown seaweed Chemical structure Fucans Fucoidans Sargassum stenophyllum Sulfated heteropolysaccharides Organic acids Polysaccharides Sugars Fucoidans Carbohydrates alpha glucose alpha glucuronic acid alpha levo fucose beta galactose beta xylose chondroitin sulfate fucoidin fucose galactose glucose glucuronic acid mannose sulfur derivative unclassified drug xylose article biosynthesis drug structure echinoderm fucosylation nonhuman priority journal seaweed structure analysis Anticoagulants Blood Coagulation Humans Monosaccharides Nuclear Magnetic Resonance, Biomolecular Optical Rotation Partial Thromboplastin Time Polysaccharides Seaweed Thrombin Time algae Cucumis sativus Holothuroidea Sargassum stenophyllum |
| spellingShingle |
Brown seaweed Chemical structure Fucans Fucoidans Sargassum stenophyllum Sulfated heteropolysaccharides Organic acids Polysaccharides Sugars Fucoidans Carbohydrates alpha glucose alpha glucuronic acid alpha levo fucose beta galactose beta xylose chondroitin sulfate fucoidin fucose galactose glucose glucuronic acid mannose sulfur derivative unclassified drug xylose article biosynthesis drug structure echinoderm fucosylation nonhuman priority journal seaweed structure analysis Anticoagulants Blood Coagulation Humans Monosaccharides Nuclear Magnetic Resonance, Biomolecular Optical Rotation Partial Thromboplastin Time Polysaccharides Seaweed Thrombin Time algae Cucumis sativus Holothuroidea Sargassum stenophyllum Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| topic_facet |
Brown seaweed Chemical structure Fucans Fucoidans Sargassum stenophyllum Sulfated heteropolysaccharides Organic acids Polysaccharides Sugars Fucoidans Carbohydrates alpha glucose alpha glucuronic acid alpha levo fucose beta galactose beta xylose chondroitin sulfate fucoidin fucose galactose glucose glucuronic acid mannose sulfur derivative unclassified drug xylose article biosynthesis drug structure echinoderm fucosylation nonhuman priority journal seaweed structure analysis Anticoagulants Blood Coagulation Humans Monosaccharides Nuclear Magnetic Resonance, Biomolecular Optical Rotation Partial Thromboplastin Time Polysaccharides Seaweed Thrombin Time algae Cucumis sativus Holothuroidea Sargassum stenophyllum |
| description |
The brown seaweed Sargassum stenophyllum biosynthesizes two different sets of fucoidans. One of them is characterized by higher percentages of glucuronic acid and fewer sulfate groups, which are situated on different sugar units. α-L-Fucose was the major component but other sugars like β-D-galactose, β-D-mannose, α-D-glucuronic acid, α-D-glucose and β-D-xylose were also in substantial amounts. Fucoidans from the other set contain small amounts of α-D-glucuronic acid and high percentages of sulfate groups, which are concentrated on the fucose residues, with only fucose and galactose as major components. Structural studies of one fucoidan from each set suggest that these products have a general basic structure that has a formal resemblance to that of the fucosylated chondroitin sulfates from the body wall of sea cucumbers, namely, a linear core (formed mainly by (1→6)-β-D-galactose and/or (1→2)-β-D-mannose units) with branched chains of 'fucans' (formed by (1→3) and/or (1→4)-α-L-fucose, (1→4)-α-D-glucuronic acid, terminal β-D-xylose and, sometimes, (1→4)-α-D-glucose). In fucoidans from the second set, the 'core' is reduced to short galactan chains. © 2001 Elsevier Science Ltd. All rights reserved. |
| title |
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| title_short |
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| title_full |
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| title_fullStr |
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| title_full_unstemmed |
Structural studies on fucoidans from the brown seaweed Sargassum stenophyllum |
| title_sort |
structural studies on fucoidans from the brown seaweed sargassum stenophyllum |
| publishDate |
2001 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v333_n4_p281_Duarte http://hdl.handle.net/20.500.12110/paper_00086215_v333_n4_p281_Duarte |
| _version_ |
1768546283335712768 |