Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose

3-Deoxy-D-erythro-hexos-2-ulose bis(thiosemicarbazone) (1) acts as a tetradentate ligand of the N2S2 type which forms stable coordination complexes with metal(II) cations. The Cu(II), Pt(II), and Pd(II) chelates (2, 4, and 6, respectively) of 1 were synthesized and characterized by elemental analysi...

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Publicado:	2000
Materias:	Bis(thiosemicarbazone) Chelates Copper Palladium Platinum 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate acetic acid derivative chelate copper glucose hydrogen sulfide metal ion palladium complex platinum thiosemicarbazone derivative unclassified drug antiviral activity article complex formation nuclear magnetic resonance spectroscopy Poliomyelitis virus 1 priority journal Animal Antiviral Agents Cercopithecus aethiops Glucose Human Magnetic Resonance Spectroscopy Platinum Compounds Poliovirus Thiosemicarbazones Vero Cells
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v328_n3_p425_Horton http://hdl.handle.net/20.500.12110/paper_00086215_v328_n3_p425_Horton
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00086215_v328_n3_p425_Horton
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spelling	paper:paper_00086215_v328_n3_p425_Horton2023-06-08T14:32:38Z Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose Bis(thiosemicarbazone) Chelates Copper Palladium Platinum 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate acetic acid derivative chelate copper glucose hydrogen sulfide metal ion palladium complex platinum thiosemicarbazone derivative unclassified drug antiviral activity article complex formation nuclear magnetic resonance spectroscopy Poliomyelitis virus 1 priority journal Animal Antiviral Agents Cercopithecus aethiops Copper Glucose Human Magnetic Resonance Spectroscopy Palladium Platinum Compounds Poliovirus Thiosemicarbazones Vero Cells 3-Deoxy-D-erythro-hexos-2-ulose bis(thiosemicarbazone) (1) acts as a tetradentate ligand of the N2S2 type which forms stable coordination complexes with metal(II) cations. The Cu(II), Pt(II), and Pd(II) chelates (2, 4, and 6, respectively) of 1 were synthesized and characterized by elemental analysis and NMR spectroscopy. The NMR spectra of the Pt complex (4) showed the coupling of H-1 and C-1, C-2 of the bis(thiosemicarbazone) with 195Pt (33.7% naturally occurring), which supports the structure proposed for the chelate. The complexes 2, 4, and 6 were acetylated to give the corresponding tri-O-acetyl derivatives 3, 5, and 7. Elimination of Cu(II) from 3 with hydrogen sulfide afforded 8, the tri-O-acetyl derivative of 1. Preliminary studies have shown antiviral activity of chelates 2, 4, and 6 against poliovirus type 1. (C) 2000 Elsevier Science Ltd. 2000 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v328_n3_p425_Horton http://hdl.handle.net/20.500.12110/paper_00086215_v328_n3_p425_Horton
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Bis(thiosemicarbazone) Chelates Copper Palladium Platinum 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate acetic acid derivative chelate copper glucose hydrogen sulfide metal ion palladium complex platinum thiosemicarbazone derivative unclassified drug antiviral activity article complex formation nuclear magnetic resonance spectroscopy Poliomyelitis virus 1 priority journal Animal Antiviral Agents Cercopithecus aethiops Copper Glucose Human Magnetic Resonance Spectroscopy Palladium Platinum Compounds Poliovirus Thiosemicarbazones Vero Cells
spellingShingle	Bis(thiosemicarbazone) Chelates Copper Palladium Platinum 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate acetic acid derivative chelate copper glucose hydrogen sulfide metal ion palladium complex platinum thiosemicarbazone derivative unclassified drug antiviral activity article complex formation nuclear magnetic resonance spectroscopy Poliomyelitis virus 1 priority journal Animal Antiviral Agents Cercopithecus aethiops Copper Glucose Human Magnetic Resonance Spectroscopy Palladium Platinum Compounds Poliovirus Thiosemicarbazones Vero Cells Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
topic_facet	Bis(thiosemicarbazone) Chelates Copper Palladium Platinum 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) palladium chelate 3 deoxy dextro erythro hexos 2 ulose bis(thiosemicarbazone) platinum chelate acetic acid derivative chelate copper glucose hydrogen sulfide metal ion palladium complex platinum thiosemicarbazone derivative unclassified drug antiviral activity article complex formation nuclear magnetic resonance spectroscopy Poliomyelitis virus 1 priority journal Animal Antiviral Agents Cercopithecus aethiops Copper Glucose Human Magnetic Resonance Spectroscopy Palladium Platinum Compounds Poliovirus Thiosemicarbazones Vero Cells
description	3-Deoxy-D-erythro-hexos-2-ulose bis(thiosemicarbazone) (1) acts as a tetradentate ligand of the N2S2 type which forms stable coordination complexes with metal(II) cations. The Cu(II), Pt(II), and Pd(II) chelates (2, 4, and 6, respectively) of 1 were synthesized and characterized by elemental analysis and NMR spectroscopy. The NMR spectra of the Pt complex (4) showed the coupling of H-1 and C-1, C-2 of the bis(thiosemicarbazone) with 195Pt (33.7% naturally occurring), which supports the structure proposed for the chelate. The complexes 2, 4, and 6 were acetylated to give the corresponding tri-O-acetyl derivatives 3, 5, and 7. Elimination of Cu(II) from 3 with hydrogen sulfide afforded 8, the tri-O-acetyl derivative of 1. Preliminary studies have shown antiviral activity of chelates 2, 4, and 6 against poliovirus type 1. (C) 2000 Elsevier Science Ltd.
title	Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
title_short	Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
title_full	Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
title_fullStr	Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
title_full_unstemmed	Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose
title_sort	cu, pt, and pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from d-glucose
publishDate	2000
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00086215_v328_n3_p425_Horton http://hdl.handle.net/20.500.12110/paper_00086215_v328_n3_p425_Horton
_version_	1768541779078938624

Cu, Pt, and Pd complexes of the 3-deoxy-1,2-bis(thiosemicarbazone) derived from D-glucose

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