Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients
BACKGROUND. Bone marrow (BM) is an important tissue in the generation of immunocompetent and peripheral blood cells. The precursors of hematopoietic cells in BM undergo continuous proliferation and differentiation and are highly vulnerable to acute and chronic oxidative stress. Little is known about...
Guardado en:
| Publicado: |
2002
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0008543X_v94_n12_p3247_DeCavanagh http://hdl.handle.net/20.500.12110/paper_0008543X_v94_n12_p3247_DeCavanagh |
| Aporte de: |
| id |
paper:paper_0008543X_v94_n12_p3247_DeCavanagh |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_0008543X_v94_n12_p3247_DeCavanagh2023-06-08T14:32:07Z Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients Antioxidants Bone marrow Cancer Free radicals Lipid oxidation Peripheral blood alpha tocopherol antioxidant beta carotene free radical thiobarbituric acid reactive substance adult advanced cancer article blood bone marrow breast carcinoma chemoluminescence clinical article human lipid oxidation lung carcinoma oxidation oxidative stress plasma priority journal Adult Antioxidants Bone Marrow Chemiluminescent Measurements Humans Lipid Peroxidation Middle Aged Neoplasms Neutrophils Oxidation-Reduction BACKGROUND. Bone marrow (BM) is an important tissue in the generation of immunocompetent and peripheral blood cells. The precursors of hematopoietic cells in BM undergo continuous proliferation and differentiation and are highly vulnerable to acute and chronic oxidative stress. Little is known about the oxidant and antioxidant status in the BM of untreated patients with nonhematologic tumors. In this study, oxidative stress was evaluated in peripheral blood plasma (PBP) and BM plasma (BMP) from lung carcinoma (LC) and breast carcinoma (BC) patients. METHODS. The sample included 13 consecutive untreated LC patients, 15 BC patients, and 11 healthy controls. Luminol-dependent chemiluminescence was used to evaluate oxygen radical generation by peripheral blood neutrophils. Lipid oxidation, assessed by 2-thiobarbituric acid-reactive substances (TBARS), and α-tocopherol, β-carotene, and total ubiquinol-10 levels were determined in PBP and BMP. RESULTS. In LC and BC patients, neutrophil chemiluminescence was higher (128% and 264%, respectively) than in controls (P < 0.05). In cancer patients, TBARS levels were higher in both PBP (51% and 243% for LC and BC patients, respectively) and BMP (66% and 305% for LC and BC patients, respectively) than in plasma from controls (P < 0.01). α-Tocopherol and total ubiquinol-10 levels were significantly lower in BMP from BC patients compared with controls. In BC patients, α-tocopherol content in PBP was significantly lower than in controls. CONCLUSIONS. Untreated cancer patients presented an imbalance between oxidant generation and lipid-soluble antioxidant levels in favor of the former. © 2002 American Cancer Society. 2002 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0008543X_v94_n12_p3247_DeCavanagh http://hdl.handle.net/20.500.12110/paper_0008543X_v94_n12_p3247_DeCavanagh |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antioxidants Bone marrow Cancer Free radicals Lipid oxidation Peripheral blood alpha tocopherol antioxidant beta carotene free radical thiobarbituric acid reactive substance adult advanced cancer article blood bone marrow breast carcinoma chemoluminescence clinical article human lipid oxidation lung carcinoma oxidation oxidative stress plasma priority journal Adult Antioxidants Bone Marrow Chemiluminescent Measurements Humans Lipid Peroxidation Middle Aged Neoplasms Neutrophils Oxidation-Reduction |
| spellingShingle |
Antioxidants Bone marrow Cancer Free radicals Lipid oxidation Peripheral blood alpha tocopherol antioxidant beta carotene free radical thiobarbituric acid reactive substance adult advanced cancer article blood bone marrow breast carcinoma chemoluminescence clinical article human lipid oxidation lung carcinoma oxidation oxidative stress plasma priority journal Adult Antioxidants Bone Marrow Chemiluminescent Measurements Humans Lipid Peroxidation Middle Aged Neoplasms Neutrophils Oxidation-Reduction Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| topic_facet |
Antioxidants Bone marrow Cancer Free radicals Lipid oxidation Peripheral blood alpha tocopherol antioxidant beta carotene free radical thiobarbituric acid reactive substance adult advanced cancer article blood bone marrow breast carcinoma chemoluminescence clinical article human lipid oxidation lung carcinoma oxidation oxidative stress plasma priority journal Adult Antioxidants Bone Marrow Chemiluminescent Measurements Humans Lipid Peroxidation Middle Aged Neoplasms Neutrophils Oxidation-Reduction |
| description |
BACKGROUND. Bone marrow (BM) is an important tissue in the generation of immunocompetent and peripheral blood cells. The precursors of hematopoietic cells in BM undergo continuous proliferation and differentiation and are highly vulnerable to acute and chronic oxidative stress. Little is known about the oxidant and antioxidant status in the BM of untreated patients with nonhematologic tumors. In this study, oxidative stress was evaluated in peripheral blood plasma (PBP) and BM plasma (BMP) from lung carcinoma (LC) and breast carcinoma (BC) patients. METHODS. The sample included 13 consecutive untreated LC patients, 15 BC patients, and 11 healthy controls. Luminol-dependent chemiluminescence was used to evaluate oxygen radical generation by peripheral blood neutrophils. Lipid oxidation, assessed by 2-thiobarbituric acid-reactive substances (TBARS), and α-tocopherol, β-carotene, and total ubiquinol-10 levels were determined in PBP and BMP. RESULTS. In LC and BC patients, neutrophil chemiluminescence was higher (128% and 264%, respectively) than in controls (P < 0.05). In cancer patients, TBARS levels were higher in both PBP (51% and 243% for LC and BC patients, respectively) and BMP (66% and 305% for LC and BC patients, respectively) than in plasma from controls (P < 0.01). α-Tocopherol and total ubiquinol-10 levels were significantly lower in BMP from BC patients compared with controls. In BC patients, α-tocopherol content in PBP was significantly lower than in controls. CONCLUSIONS. Untreated cancer patients presented an imbalance between oxidant generation and lipid-soluble antioxidant levels in favor of the former. © 2002 American Cancer Society. |
| title |
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| title_short |
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| title_full |
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| title_fullStr |
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| title_full_unstemmed |
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| title_sort |
higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patients |
| publishDate |
2002 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0008543X_v94_n12_p3247_DeCavanagh http://hdl.handle.net/20.500.12110/paper_0008543X_v94_n12_p3247_DeCavanagh |
| _version_ |
1768543732707098624 |