Role of corticosteroids in distal acidification of amiloride-treated rats
The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. A...
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1992
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v70_n5_p695_Ansaldo http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo |
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paper:paper_00084212_v70_n5_p695_Ansaldo2023-06-08T14:32:02Z Role of corticosteroids in distal acidification of amiloride-treated rats Ansaldo, Martín 18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. Adrenalectomy further reduced U-B PCO2 in amiloride-treated, bicarbonate-infused rats (from 27.9 ± 1.82 mmHg in sham-operated rats to 21.3 ± 1.58 mmHg in adrenalectomized (ADX) rats) (1 mmHg = 133.322 Pa). Acute administration of corticosterone and 18-hydroxycorticosterone (18-OH-B), but not of aldosterone, caused recovery of U-B PCO2 to the level of sham-operated animals treated with amiloride. Aldosterone did not affect U-B PCO2 in the presence of amiloride (21.9 mmHg ADX group vs. 20.98 mmHg aldosterone group). Results are compatible with aldosterone affecting distal H ion secretion mostly by a sodium and potential difference dependent mechanism, while corticosterone and 18-OH-B should act by other mechanisms (e.g., increased luminal buffer level). Fil:Ansaldo, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1992 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v70_n5_p695_Ansaldo http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification |
| spellingShingle |
18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification Ansaldo, Martín Role of corticosteroids in distal acidification of amiloride-treated rats |
| topic_facet |
18-hydroxycorticosterone adrenalectomy aldosterone amiloride corticos terone corticosteroids distal H ion secretion 18 hydroxycorticosterone aldosterone amiloride corticosterone adrenalectomy animal experiment article controlled study intramuscular drug administration intravenous drug administration kidney distal tubule male nonhuman priority journal rat urine acidification |
| description |
The role of amiloride-dependent sodium channels in the action of adrenal cortical steroids on urine-blood PCO2 (U-B PCO2) differences was studied in bicarbonate-infused and amiloride-treated adrenalectomized rats. U-B PCO2 was significantly reduced by amiloride in bicarbonate-infused control rats. Adrenalectomy further reduced U-B PCO2 in amiloride-treated, bicarbonate-infused rats (from 27.9 ± 1.82 mmHg in sham-operated rats to 21.3 ± 1.58 mmHg in adrenalectomized (ADX) rats) (1 mmHg = 133.322 Pa). Acute administration of corticosterone and 18-hydroxycorticosterone (18-OH-B), but not of aldosterone, caused recovery of U-B PCO2 to the level of sham-operated animals treated with amiloride. Aldosterone did not affect U-B PCO2 in the presence of amiloride (21.9 mmHg ADX group vs. 20.98 mmHg aldosterone group). Results are compatible with aldosterone affecting distal H ion secretion mostly by a sodium and potential difference dependent mechanism, while corticosterone and 18-OH-B should act by other mechanisms (e.g., increased luminal buffer level). |
| author |
Ansaldo, Martín |
| author_facet |
Ansaldo, Martín |
| author_sort |
Ansaldo, Martín |
| title |
Role of corticosteroids in distal acidification of amiloride-treated rats |
| title_short |
Role of corticosteroids in distal acidification of amiloride-treated rats |
| title_full |
Role of corticosteroids in distal acidification of amiloride-treated rats |
| title_fullStr |
Role of corticosteroids in distal acidification of amiloride-treated rats |
| title_full_unstemmed |
Role of corticosteroids in distal acidification of amiloride-treated rats |
| title_sort |
role of corticosteroids in distal acidification of amiloride-treated rats |
| publishDate |
1992 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v70_n5_p695_Ansaldo http://hdl.handle.net/20.500.12110/paper_00084212_v70_n5_p695_Ansaldo |
| work_keys_str_mv |
AT ansaldomartin roleofcorticosteroidsindistalacidificationofamiloridetreatedrats |
| _version_ |
1768543494281887744 |