Metabolism of [3H]noradrenaline by the isolated rat uterus
The metabolism of [3H]noradrenaline by uterine horns from estrous, ovariectomized, and ovariectomized and estrogen-treated rats was explored. Uterine strips are able to take up [3H]noradrenaline and store it for up to 85 min after the isotope incubation. The major compounds retained in the tissue fr...
| Publicado: |
1981
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v59_n12_p1245_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00084212_v59_n12_p1245_FernandezPardal |
| Aporte de: |
| id |
paper:paper_00084212_v59_n12_p1245_FernandezPardal |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00084212_v59_n12_p1245_FernandezPardal2023-06-08T14:32:00Z Metabolism of [3H]noradrenaline by the isolated rat uterus 3,4 dihydroxymandelic acid h 3 3,4 dihydroxyphenylethylene glycol h 3 estradiol estrogen noradrenalin noradrenalin h 3 radioisotope unclassified drug estradiol estrogen noradrenalin animal experiment endocrine system estrus female genital system in vitro study ovariectomy pharmacokinetics rat uterus animal article castration estrus female metabolism pregnancy uterus Animal Castration Estradiol Estrogens Estrus Female In Vitro Norepinephrine Pregnancy Rats Support, Non-U.S. Gov't Uterus The metabolism of [3H]noradrenaline by uterine horns from estrous, ovariectomized, and ovariectomized and estrogen-treated rats was explored. Uterine strips are able to take up [3H]noradrenaline and store it for up to 85 min after the isotope incubation. The major compounds retained in the tissue from rats either ovariectomized or during estrus were [3H]noradrenaline and 3H-labelled O-methylated deaminate metabolites. The [3H]3,4-dihydroxyphenylglycol ([3H]DOPEG) and 3,4-dihydroxymandelic acid ([3H]DOMA) fractions were higher in tissues from ovariectomized rats than during estrus. Ovariectomy also increased significantly spontaneous efflux of [3H]DOPEG and [3H]DOMA. The metabolic pattern of [3H]noradrenaline both in the tissue and in the efflux from ovariectomized rats was changed by estrogen treatment and became similar to those obtained during estrus. These data suggest a possible modulation of the noradrenaline metabolism by estrogens on the isolated rat uterus. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v59_n12_p1245_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00084212_v59_n12_p1245_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
3,4 dihydroxymandelic acid h 3 3,4 dihydroxyphenylethylene glycol h 3 estradiol estrogen noradrenalin noradrenalin h 3 radioisotope unclassified drug estradiol estrogen noradrenalin animal experiment endocrine system estrus female genital system in vitro study ovariectomy pharmacokinetics rat uterus animal article castration estrus female metabolism pregnancy uterus Animal Castration Estradiol Estrogens Estrus Female In Vitro Norepinephrine Pregnancy Rats Support, Non-U.S. Gov't Uterus |
| spellingShingle |
3,4 dihydroxymandelic acid h 3 3,4 dihydroxyphenylethylene glycol h 3 estradiol estrogen noradrenalin noradrenalin h 3 radioisotope unclassified drug estradiol estrogen noradrenalin animal experiment endocrine system estrus female genital system in vitro study ovariectomy pharmacokinetics rat uterus animal article castration estrus female metabolism pregnancy uterus Animal Castration Estradiol Estrogens Estrus Female In Vitro Norepinephrine Pregnancy Rats Support, Non-U.S. Gov't Uterus Metabolism of [3H]noradrenaline by the isolated rat uterus |
| topic_facet |
3,4 dihydroxymandelic acid h 3 3,4 dihydroxyphenylethylene glycol h 3 estradiol estrogen noradrenalin noradrenalin h 3 radioisotope unclassified drug estradiol estrogen noradrenalin animal experiment endocrine system estrus female genital system in vitro study ovariectomy pharmacokinetics rat uterus animal article castration estrus female metabolism pregnancy uterus Animal Castration Estradiol Estrogens Estrus Female In Vitro Norepinephrine Pregnancy Rats Support, Non-U.S. Gov't Uterus |
| description |
The metabolism of [3H]noradrenaline by uterine horns from estrous, ovariectomized, and ovariectomized and estrogen-treated rats was explored. Uterine strips are able to take up [3H]noradrenaline and store it for up to 85 min after the isotope incubation. The major compounds retained in the tissue from rats either ovariectomized or during estrus were [3H]noradrenaline and 3H-labelled O-methylated deaminate metabolites. The [3H]3,4-dihydroxyphenylglycol ([3H]DOPEG) and 3,4-dihydroxymandelic acid ([3H]DOMA) fractions were higher in tissues from ovariectomized rats than during estrus. Ovariectomy also increased significantly spontaneous efflux of [3H]DOPEG and [3H]DOMA. The metabolic pattern of [3H]noradrenaline both in the tissue and in the efflux from ovariectomized rats was changed by estrogen treatment and became similar to those obtained during estrus. These data suggest a possible modulation of the noradrenaline metabolism by estrogens on the isolated rat uterus. |
| title |
Metabolism of [3H]noradrenaline by the isolated rat uterus |
| title_short |
Metabolism of [3H]noradrenaline by the isolated rat uterus |
| title_full |
Metabolism of [3H]noradrenaline by the isolated rat uterus |
| title_fullStr |
Metabolism of [3H]noradrenaline by the isolated rat uterus |
| title_full_unstemmed |
Metabolism of [3H]noradrenaline by the isolated rat uterus |
| title_sort |
metabolism of [3h]noradrenaline by the isolated rat uterus |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00084212_v59_n12_p1245_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00084212_v59_n12_p1245_FernandezPardal |
| _version_ |
1768542817094729728 |