Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation

Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are i...

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Detalles Bibliográficos
Autores principales:	Strier, Damián, Ventura, Alejandra C., Ponce Dawson, Silvina
Publicado:	2003
Materias:	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063495_v85_n6_p3575_Strier http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00063495_v85_n6_p3575_Strier
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spelling	paper:paper_00063495_v85_n6_p3575_Strier2023-06-08T14:31:17Z Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation Strier, Damián Ventura, Alejandra C. Ponce Dawson, Silvina calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are in equilibrium with calcium (the rapid buffering approximation). In this article we address the issue of whether this approximation provides a good description of wave propagation. We first compare the timescales present in the problem, and determine the situations in which the equilibrium hypothesis fails. We then present a series of numerical studies based on the simple fire-diffuse-fire model of wave propagation. We find that the differences between the full and reduced descriptions may lead to errors that are above experimental resolution even for relatively fast buffers in the case of saltatory waves. Conversely, in the case of continuous waves, the approximation may give accurate results even for relatively slow buffers. Fil:Strier, D.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ventura, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Dawson, S.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063495_v85_n6_p3575_Strier http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
spellingShingle	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology Strier, Damián Ventura, Alejandra C. Ponce Dawson, Silvina Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
topic_facet	calcium channel calcium ion article calcium cell level calcium signaling calcium transport cytosol intracellular transport phenomenology
description	Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. However, most models of calcium waves either treat buffers phenomenologically or assume that they are in equilibrium with calcium (the rapid buffering approximation). In this article we address the issue of whether this approximation provides a good description of wave propagation. We first compare the timescales present in the problem, and determine the situations in which the equilibrium hypothesis fails. We then present a series of numerical studies based on the simple fire-diffuse-fire model of wave propagation. We find that the differences between the full and reduced descriptions may lead to errors that are above experimental resolution even for relatively fast buffers in the case of saltatory waves. Conversely, in the case of continuous waves, the approximation may give accurate results even for relatively slow buffers.
author	Strier, Damián Ventura, Alejandra C. Ponce Dawson, Silvina
author_facet	Strier, Damián Ventura, Alejandra C. Ponce Dawson, Silvina
author_sort	Strier, Damián
title	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_short	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_full	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_fullStr	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_full_unstemmed	Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation
title_sort	saltatory and continuous calcium waves and the rapid buffering approximation
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063495_v85_n6_p3575_Strier http://hdl.handle.net/20.500.12110/paper_00063495_v85_n6_p3575_Strier
work_keys_str_mv	AT strierdamian saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation AT venturaalejandrac saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation AT poncedawsonsilvina saltatoryandcontinuouscalciumwavesandtherapidbufferingapproximation
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Saltatory and Continuous Calcium Waves and the Rapid Buffering Approximation

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