Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus
Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling...
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063223_v77_n6_p513_Rocchetti http://hdl.handle.net/20.500.12110/paper_00063223_v77_n6_p513_Rocchetti |
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paper:paper_00063223_v77_n6_p513_Rocchetti2023-06-08T14:30:58Z Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus Rubinstein, Marcelo Antipsychotics D 2 dopamine receptors LTD Memory Neuronal plasticity Temporal hippocampus dopamine dopamine 2 receptor presynaptic receptor dopamine 2 receptor dopamine 2 receptor blocking agent DRD2 protein, mouse messenger RNA animal experiment animal tissue Article brain electrophysiology cognitive defect controlled study dopaminergic transmission gene expression hippocampal CA1 region hippocampus long term depression long term potentiation male memory disorder mouse nerve cell plasticity neuroanatomy neurochemistry neuromodulation nonhuman priority journal regulatory mechanism spatial learning spatial memory task performance animal C57BL mouse depth perception drug effects excitatory postsynaptic potential genetics hippocampus learning long term depression memory metabolism nerve tract physiology transgenic mouse ventral tegmentum Animals Dopamine D2 Receptor Antagonists Excitatory Postsynaptic Potentials Hippocampus Learning Long-Term Potentiation Long-Term Synaptic Depression Male Memory Mice, Inbred C57BL Mice, Transgenic Neural Pathways Receptors, Dopamine D2 RNA, Messenger Space Perception Ventral Tegmental Area Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling deeply alters hippocampal functions. However, given the lack of full characterization of a functional mesohippocampal pathway, the precise role of dopamine transmission in memory deficits associated with these disorders and their dedicated therapies is unknown. In particular, the positive outcome of antipsychotic treatments, commonly antagonizing D 2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questionable. Methods Following pharmacologic and genetic manipulation of dopamine transmission, we performed anatomic, neurochemical, electrophysiologic, and behavioral investigations to uncover the role of D2Rs in hippocampal-dependent plasticity and learning. Naïve mice (n = 4-21) were used in the different procedures. Results Dopamine modulated both long-term potentiation and long-term depression in the temporal hippocampus as well as spatial and recognition learning and memory in mice through D2Rs. Although genetic deletion or pharmacologic blockade of D2Rs led to the loss of long-term potentiation expression, the specific genetic removal of presynaptic D2Rs impaired long-term depression and performances on spatial memory tasks. Conclusions Presynaptic D2Rs in dopamine fibers of the temporal hippocampus tightly modulate long-term depression expression and play a major role in the regulation of hippocampal learning and memory. This direct role of mesohippocampal dopamine input as uncovered here adds a new dimension to dopamine involvement in the physiology underlying deficits associated with neuropsychiatric disorders. © 2015 Society of Biological Psychiatry. Fil:Rubinstein, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063223_v77_n6_p513_Rocchetti http://hdl.handle.net/20.500.12110/paper_00063223_v77_n6_p513_Rocchetti |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Antipsychotics D 2 dopamine receptors LTD Memory Neuronal plasticity Temporal hippocampus dopamine dopamine 2 receptor presynaptic receptor dopamine 2 receptor dopamine 2 receptor blocking agent DRD2 protein, mouse messenger RNA animal experiment animal tissue Article brain electrophysiology cognitive defect controlled study dopaminergic transmission gene expression hippocampal CA1 region hippocampus long term depression long term potentiation male memory disorder mouse nerve cell plasticity neuroanatomy neurochemistry neuromodulation nonhuman priority journal regulatory mechanism spatial learning spatial memory task performance animal C57BL mouse depth perception drug effects excitatory postsynaptic potential genetics hippocampus learning long term depression memory metabolism nerve tract physiology transgenic mouse ventral tegmentum Animals Dopamine D2 Receptor Antagonists Excitatory Postsynaptic Potentials Hippocampus Learning Long-Term Potentiation Long-Term Synaptic Depression Male Memory Mice, Inbred C57BL Mice, Transgenic Neural Pathways Receptors, Dopamine D2 RNA, Messenger Space Perception Ventral Tegmental Area |
| spellingShingle |
Antipsychotics D 2 dopamine receptors LTD Memory Neuronal plasticity Temporal hippocampus dopamine dopamine 2 receptor presynaptic receptor dopamine 2 receptor dopamine 2 receptor blocking agent DRD2 protein, mouse messenger RNA animal experiment animal tissue Article brain electrophysiology cognitive defect controlled study dopaminergic transmission gene expression hippocampal CA1 region hippocampus long term depression long term potentiation male memory disorder mouse nerve cell plasticity neuroanatomy neurochemistry neuromodulation nonhuman priority journal regulatory mechanism spatial learning spatial memory task performance animal C57BL mouse depth perception drug effects excitatory postsynaptic potential genetics hippocampus learning long term depression memory metabolism nerve tract physiology transgenic mouse ventral tegmentum Animals Dopamine D2 Receptor Antagonists Excitatory Postsynaptic Potentials Hippocampus Learning Long-Term Potentiation Long-Term Synaptic Depression Male Memory Mice, Inbred C57BL Mice, Transgenic Neural Pathways Receptors, Dopamine D2 RNA, Messenger Space Perception Ventral Tegmental Area Rubinstein, Marcelo Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| topic_facet |
Antipsychotics D 2 dopamine receptors LTD Memory Neuronal plasticity Temporal hippocampus dopamine dopamine 2 receptor presynaptic receptor dopamine 2 receptor dopamine 2 receptor blocking agent DRD2 protein, mouse messenger RNA animal experiment animal tissue Article brain electrophysiology cognitive defect controlled study dopaminergic transmission gene expression hippocampal CA1 region hippocampus long term depression long term potentiation male memory disorder mouse nerve cell plasticity neuroanatomy neurochemistry neuromodulation nonhuman priority journal regulatory mechanism spatial learning spatial memory task performance animal C57BL mouse depth perception drug effects excitatory postsynaptic potential genetics hippocampus learning long term depression memory metabolism nerve tract physiology transgenic mouse ventral tegmentum Animals Dopamine D2 Receptor Antagonists Excitatory Postsynaptic Potentials Hippocampus Learning Long-Term Potentiation Long-Term Synaptic Depression Male Memory Mice, Inbred C57BL Mice, Transgenic Neural Pathways Receptors, Dopamine D2 RNA, Messenger Space Perception Ventral Tegmental Area |
| description |
Background Dysfunctional mesocorticolimbic dopamine signaling has been linked to alterations in motor and reward-based functions associated with psychiatric disorders. Converging evidence from patients with psychiatric disorders and use of antipsychotics suggests that imbalance of dopamine signaling deeply alters hippocampal functions. However, given the lack of full characterization of a functional mesohippocampal pathway, the precise role of dopamine transmission in memory deficits associated with these disorders and their dedicated therapies is unknown. In particular, the positive outcome of antipsychotic treatments, commonly antagonizing D 2 dopamine receptors (D2Rs), on cognitive deficits and memory impairments remains questionable. Methods Following pharmacologic and genetic manipulation of dopamine transmission, we performed anatomic, neurochemical, electrophysiologic, and behavioral investigations to uncover the role of D2Rs in hippocampal-dependent plasticity and learning. Naïve mice (n = 4-21) were used in the different procedures. Results Dopamine modulated both long-term potentiation and long-term depression in the temporal hippocampus as well as spatial and recognition learning and memory in mice through D2Rs. Although genetic deletion or pharmacologic blockade of D2Rs led to the loss of long-term potentiation expression, the specific genetic removal of presynaptic D2Rs impaired long-term depression and performances on spatial memory tasks. Conclusions Presynaptic D2Rs in dopamine fibers of the temporal hippocampus tightly modulate long-term depression expression and play a major role in the regulation of hippocampal learning and memory. This direct role of mesohippocampal dopamine input as uncovered here adds a new dimension to dopamine involvement in the physiology underlying deficits associated with neuropsychiatric disorders. © 2015 Society of Biological Psychiatry. |
| author |
Rubinstein, Marcelo |
| author_facet |
Rubinstein, Marcelo |
| author_sort |
Rubinstein, Marcelo |
| title |
Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| title_short |
Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| title_full |
Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| title_fullStr |
Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| title_full_unstemmed |
Presynaptic D 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| title_sort |
presynaptic d 2 dopamine receptors control long-term depression expression and memory processes in the temporal hippocampus |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063223_v77_n6_p513_Rocchetti http://hdl.handle.net/20.500.12110/paper_00063223_v77_n6_p513_Rocchetti |
| work_keys_str_mv |
AT rubinsteinmarcelo presynapticd2dopaminereceptorscontrollongtermdepressionexpressionandmemoryprocessesinthetemporalhippocampus |
| _version_ |
1768543589691817984 |