Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus
Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the mole...
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2006
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063185_v210_n3_p280_Romano http://hdl.handle.net/20.500.12110/paper_00063185_v210_n3_p280_Romano |
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paper:paper_00063185_v210_n3_p280_Romano2023-06-08T14:30:55Z Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus amyloid precursor protein cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein mitogen activated protein kinase crab enzyme activity gene expression memory protein animal animal model biological model Brachyura memory metabolism physiology review signal transduction synaptic transmission Amyloid beta-Protein Precursor Animals Brachyura Cyclic AMP-Dependent Protein Kinases Extracellular Signal-Regulated MAP Kinases Memory Models, Animal Models, Neurological NF-kappa B Signal Transduction Synaptic Transmission Chasmagnathus Decapoda (Crustacea) Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the molecular mechanisms involved in such processes, we used the context-signal associative learning paradigm of the crab Chasmagnathus. In this model, we studied the role of some molecular mechanisms, namely cAMP-dependent protein kinase (PKA), extracellular-signal-regulated kinase (ERK), the nuclear factor kappa B (NF-κB) transcription factor, and the role of synaptic proteins such as amyloid β precursor protein, with the object of describing key mechanisms involved in memory processing. In this article we review the most salient results obtained over a decade of research in this memory model. © 2006 Marine Biological Laboratory. 2006 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063185_v210_n3_p280_Romano http://hdl.handle.net/20.500.12110/paper_00063185_v210_n3_p280_Romano |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
amyloid precursor protein cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein mitogen activated protein kinase crab enzyme activity gene expression memory protein animal animal model biological model Brachyura memory metabolism physiology review signal transduction synaptic transmission Amyloid beta-Protein Precursor Animals Brachyura Cyclic AMP-Dependent Protein Kinases Extracellular Signal-Regulated MAP Kinases Memory Models, Animal Models, Neurological NF-kappa B Signal Transduction Synaptic Transmission Chasmagnathus Decapoda (Crustacea) |
| spellingShingle |
amyloid precursor protein cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein mitogen activated protein kinase crab enzyme activity gene expression memory protein animal animal model biological model Brachyura memory metabolism physiology review signal transduction synaptic transmission Amyloid beta-Protein Precursor Animals Brachyura Cyclic AMP-Dependent Protein Kinases Extracellular Signal-Regulated MAP Kinases Memory Models, Animal Models, Neurological NF-kappa B Signal Transduction Synaptic Transmission Chasmagnathus Decapoda (Crustacea) Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| topic_facet |
amyloid precursor protein cyclic AMP dependent protein kinase immunoglobulin enhancer binding protein mitogen activated protein kinase crab enzyme activity gene expression memory protein animal animal model biological model Brachyura memory metabolism physiology review signal transduction synaptic transmission Amyloid beta-Protein Precursor Animals Brachyura Cyclic AMP-Dependent Protein Kinases Extracellular Signal-Regulated MAP Kinases Memory Models, Animal Models, Neurological NF-kappa B Signal Transduction Synaptic Transmission Chasmagnathus Decapoda (Crustacea) |
| description |
Consolidation of long-term memory requires the activation of several transduction pathways that lead to post-translational modifications of synaptic proteins and to regulation of gene expression, both of which promote stabilization of specific changes in the activated circuits. In search of the molecular mechanisms involved in such processes, we used the context-signal associative learning paradigm of the crab Chasmagnathus. In this model, we studied the role of some molecular mechanisms, namely cAMP-dependent protein kinase (PKA), extracellular-signal-regulated kinase (ERK), the nuclear factor kappa B (NF-κB) transcription factor, and the role of synaptic proteins such as amyloid β precursor protein, with the object of describing key mechanisms involved in memory processing. In this article we review the most salient results obtained over a decade of research in this memory model. © 2006 Marine Biological Laboratory. |
| title |
Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| title_short |
Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| title_full |
Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| title_fullStr |
Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| title_full_unstemmed |
Lessons from a crab: Molecular mechanisms in different memory phases of Chasmagnathus |
| title_sort |
lessons from a crab: molecular mechanisms in different memory phases of chasmagnathus |
| publishDate |
2006 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00063185_v210_n3_p280_Romano http://hdl.handle.net/20.500.12110/paper_00063185_v210_n3_p280_Romano |
| _version_ |
1768545123341172736 |