A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology

GTP, GTP- γ -S and Gpp(NH)p produced a significant activation of Mg 2+ -dependent adenylyl cyclase in permeabilized cells of Candida albicans. This activation was inhibited by GDP- β -S. Maximal stimulation (4-6 fold) was obtained when Mg 2+ and GTP- γ -S were added during permeabilization. The guan...

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Autores principales:	Paveto, María Cristina, Egidy, Giorgia Anna Rosa, Galvagno, Miguel Angel
Publicado:	1990
Materias:	adenylate cyclase glucagon guanosine triphosphate article candida albicans cell structure fungus nonhuman priority journal Adenylate Cyclase Candida albicans Enzyme Activation Glucagon Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate Guanylyl Imidodiphosphate Kinetics Magnesium Support, Non-U.S. Gov't Thionucleotides Fungi
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v167_n3_p1177_Paveto http://hdl.handle.net/20.500.12110/paper_0006291X_v167_n3_p1177_Paveto
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0006291X_v167_n3_p1177_Paveto
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spelling	paper:paper_0006291X_v167_n3_p1177_Paveto2025-07-30T17:13:23Z A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology Paveto, María Cristina Egidy, Giorgia Anna Rosa Galvagno, Miguel Angel adenylate cyclase glucagon guanosine triphosphate article candida albicans cell structure fungus nonhuman priority journal Adenylate Cyclase Candida albicans Enzyme Activation Glucagon Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate Guanylyl Imidodiphosphate Kinetics Magnesium Support, Non-U.S. Gov't Thionucleotides Candida albicans Fungi GTP, GTP- γ -S and Gpp(NH)p produced a significant activation of Mg 2+ -dependent adenylyl cyclase in permeabilized cells of Candida albicans. This activation was inhibited by GDP- β -S. Maximal stimulation (4-6 fold) was obtained when Mg 2+ and GTP- γ -S were added during permeabilization. The guanine nucleotide-stimulated activity could be further activated by glucagon in a dose dependent manner being the maximal stimulation (4-5 fold) attained at 10 -6 M glucagon. Addition of the hormone to yeast cells incubated under conditions conducive to produce germ tubes blocked hyphal development and promoted multibudded cell morphology. © 1990. Fil:Paveto, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Egidy, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Galvagno, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v167_n3_p1177_Paveto http://hdl.handle.net/20.500.12110/paper_0006291X_v167_n3_p1177_Paveto
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	adenylate cyclase glucagon guanosine triphosphate article candida albicans cell structure fungus nonhuman priority journal Adenylate Cyclase Candida albicans Enzyme Activation Glucagon Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate Guanylyl Imidodiphosphate Kinetics Magnesium Support, Non-U.S. Gov't Thionucleotides Candida albicans Fungi
spellingShingle	adenylate cyclase glucagon guanosine triphosphate article candida albicans cell structure fungus nonhuman priority journal Adenylate Cyclase Candida albicans Enzyme Activation Glucagon Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate Guanylyl Imidodiphosphate Kinetics Magnesium Support, Non-U.S. Gov't Thionucleotides Candida albicans Fungi Paveto, María Cristina Egidy, Giorgia Anna Rosa Galvagno, Miguel Angel A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
topic_facet	adenylate cyclase glucagon guanosine triphosphate article candida albicans cell structure fungus nonhuman priority journal Adenylate Cyclase Candida albicans Enzyme Activation Glucagon Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Triphosphate Guanylyl Imidodiphosphate Kinetics Magnesium Support, Non-U.S. Gov't Thionucleotides Candida albicans Fungi
description	GTP, GTP- γ -S and Gpp(NH)p produced a significant activation of Mg 2+ -dependent adenylyl cyclase in permeabilized cells of Candida albicans. This activation was inhibited by GDP- β -S. Maximal stimulation (4-6 fold) was obtained when Mg 2+ and GTP- γ -S were added during permeabilization. The guanine nucleotide-stimulated activity could be further activated by glucagon in a dose dependent manner being the maximal stimulation (4-5 fold) attained at 10 -6 M glucagon. Addition of the hormone to yeast cells incubated under conditions conducive to produce germ tubes blocked hyphal development and promoted multibudded cell morphology. © 1990.
author	Paveto, María Cristina Egidy, Giorgia Anna Rosa Galvagno, Miguel Angel
author_facet	Paveto, María Cristina Egidy, Giorgia Anna Rosa Galvagno, Miguel Angel
author_sort	Paveto, María Cristina
title	A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
title_short	A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
title_full	A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
title_fullStr	A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
title_full_unstemmed	A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology
title_sort	guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: effect of glucagon on cell morphology
publishDate	1990
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v167_n3_p1177_Paveto http://hdl.handle.net/20.500.12110/paper_0006291X_v167_n3_p1177_Paveto
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_version_	1840326577507794944

A guanine nucleotide-sensitive, glugagon-stimulated adenylyl cyclase in candida albicans: Effect of glucagon on cell morphology

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