Rat renal medulla possess high capacity to catabolize prostaglandins

Prostaglandin E2 is converted to 15-keto-13,14 dihydro prostaglandin E2, 15-keto-prostaglandin F2α and 15-keto-13,14 dihydro prostaglandin F2α, by supernatants from rat kidney medulls. The main pathway for prostaglandin E2 inactivation is the combined action of 15 hydroxy dehydrogenase and Δ13 reduc...

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Publicado:	1984
Materias:	prostaglandin 15 hydroxysteroid dehydrogenase 9 ketoreductase animal cell kidney kidney medulla nonhuman priority journal rat Animal Carbon Radioisotopes Dinoprost Dinoprostone Kidney Medulla Kinetics Prostaglandin-Endoperoxide Synthase Prostaglandins Prostaglandins E Prostaglandins F Rats Support, Non-U.S. Gov't
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v124_n1_p69_Speziale http://hdl.handle.net/20.500.12110/paper_0006291X_v124_n1_p69_Speziale
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0006291X_v124_n1_p69_Speziale
record_format	dspace
spelling	paper:paper_0006291X_v124_n1_p69_Speziale2023-06-08T14:30:02Z Rat renal medulla possess high capacity to catabolize prostaglandins prostaglandin 15 hydroxysteroid dehydrogenase 9 ketoreductase animal cell kidney kidney medulla nonhuman priority journal rat Animal Carbon Radioisotopes Dinoprost Dinoprostone Kidney Medulla Kinetics Prostaglandin-Endoperoxide Synthase Prostaglandins Prostaglandins E Prostaglandins F Rats Support, Non-U.S. Gov't Prostaglandin E2 is converted to 15-keto-13,14 dihydro prostaglandin E2, 15-keto-prostaglandin F2α and 15-keto-13,14 dihydro prostaglandin F2α, by supernatants from rat kidney medulls. The main pathway for prostaglandin E2 inactivation is the combined action of 15 hydroxy dehydrogenase and Δ13 reductase enzymes. 9-Keto-reductase route constitutes a minor pathway. Prostaglandin F2α is converted into 15-keto-prostaglandin F2α, 15-keto-13,14 dihydro prostaglandin F2α and 15-keto-dihydro prostaglandin E2. Enzyme activities are time and substrate-concentration dependent. In the presence of an excess of substrate, rat renal medulls inactivates 40 and 56 times more prostaglandin E2 and prostaglandin F2α, respectively, than the amount which is released under basal conditions. These results are in contrast to the generally accepted concept that the kidney cortex is the sole site of renal prostaglandin catabolism, and suggest, for the first time, that rat renal medulls may be a key site for the modulation of prostaglandin levels in the kidney. © 1984. 1984 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v124_n1_p69_Speziale http://hdl.handle.net/20.500.12110/paper_0006291X_v124_n1_p69_Speziale
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	prostaglandin 15 hydroxysteroid dehydrogenase 9 ketoreductase animal cell kidney kidney medulla nonhuman priority journal rat Animal Carbon Radioisotopes Dinoprost Dinoprostone Kidney Medulla Kinetics Prostaglandin-Endoperoxide Synthase Prostaglandins Prostaglandins E Prostaglandins F Rats Support, Non-U.S. Gov't
spellingShingle	prostaglandin 15 hydroxysteroid dehydrogenase 9 ketoreductase animal cell kidney kidney medulla nonhuman priority journal rat Animal Carbon Radioisotopes Dinoprost Dinoprostone Kidney Medulla Kinetics Prostaglandin-Endoperoxide Synthase Prostaglandins Prostaglandins E Prostaglandins F Rats Support, Non-U.S. Gov't Rat renal medulla possess high capacity to catabolize prostaglandins
topic_facet	prostaglandin 15 hydroxysteroid dehydrogenase 9 ketoreductase animal cell kidney kidney medulla nonhuman priority journal rat Animal Carbon Radioisotopes Dinoprost Dinoprostone Kidney Medulla Kinetics Prostaglandin-Endoperoxide Synthase Prostaglandins Prostaglandins E Prostaglandins F Rats Support, Non-U.S. Gov't
description	Prostaglandin E2 is converted to 15-keto-13,14 dihydro prostaglandin E2, 15-keto-prostaglandin F2α and 15-keto-13,14 dihydro prostaglandin F2α, by supernatants from rat kidney medulls. The main pathway for prostaglandin E2 inactivation is the combined action of 15 hydroxy dehydrogenase and Δ13 reductase enzymes. 9-Keto-reductase route constitutes a minor pathway. Prostaglandin F2α is converted into 15-keto-prostaglandin F2α, 15-keto-13,14 dihydro prostaglandin F2α and 15-keto-dihydro prostaglandin E2. Enzyme activities are time and substrate-concentration dependent. In the presence of an excess of substrate, rat renal medulls inactivates 40 and 56 times more prostaglandin E2 and prostaglandin F2α, respectively, than the amount which is released under basal conditions. These results are in contrast to the generally accepted concept that the kidney cortex is the sole site of renal prostaglandin catabolism, and suggest, for the first time, that rat renal medulls may be a key site for the modulation of prostaglandin levels in the kidney. © 1984.
title	Rat renal medulla possess high capacity to catabolize prostaglandins
title_short	Rat renal medulla possess high capacity to catabolize prostaglandins
title_full	Rat renal medulla possess high capacity to catabolize prostaglandins
title_fullStr	Rat renal medulla possess high capacity to catabolize prostaglandins
title_full_unstemmed	Rat renal medulla possess high capacity to catabolize prostaglandins
title_sort	rat renal medulla possess high capacity to catabolize prostaglandins
publishDate	1984
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0006291X_v124_n1_p69_Speziale http://hdl.handle.net/20.500.12110/paper_0006291X_v124_n1_p69_Speziale
_version_	1768542916847861760

Rat renal medulla possess high capacity to catabolize prostaglandins

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