A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule i...

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Autores principales:	Zayat, Leonardo Martin, Calero, Cecilia Inés, Albores, Pablo, Baraldo Victorica, Luis Mario, Etchenique, Roberto
Publicado:	2003
Materias:	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n4_p882_Zayat http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00027863_v125_n4_p882_Zayat
record_format	dspace
spelling	paper:paper_00027863_v125_n4_p882_Zayat2023-06-08T14:22:39Z A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage Zayat, Leonardo Martin Calero, Cecilia Inés Albores, Pablo Baraldo Victorica, Luis Mario Etchenique, Roberto 4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society. Fil:Zayat, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Calero, C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alborés, P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baraldo, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Etchenique, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2003 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n4_p882_Zayat http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
spellingShingle	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers Zayat, Leonardo Martin Calero, Cecilia Inés Albores, Pablo Baraldo Victorica, Luis Mario Etchenique, Roberto A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
topic_facet	4 aminopyridine ligand metal complex ruthenium complex xenon action potential animal cell animal experiment animal model article cell activity controlled study covalent bond crystallization diode leech light absorption membrane permeability membrane potential nerve cell neurochemistry nonhuman nuclear magnetic resonance spectroscopy oxidation reduction potential photoactivation photochemistry quantum yield synthesis 2,2'-Dipyridyl 4-Aminopyridine Action Potentials Animals Drug Carriers Ganglia Leeches Membrane Potentials Neurons Organometallic Compounds Oxidation-Reduction Photochemistry Potassium Channel Blockers
description	A new strategy to build caged-compounds is presented. The approach is based on heterolytic photocleavage of a metal-ligand bond in a coordination compound. A ruthenium polypyridine complex, containing the neurocompound 4-amino pyridine (4AP) is used as the core of the phototrigger. The biomolecule is released by irradiation with visible light (>480 nm). The liberated 4AP promotes the activation of a leech neuron by means of blocking its K+ channels. The syntesis, characterization, and the inherent advantages of this method are discussed. Copyright © 2003 American Chemical Society.
author	Zayat, Leonardo Martin Calero, Cecilia Inés Albores, Pablo Baraldo Victorica, Luis Mario Etchenique, Roberto
author_facet	Zayat, Leonardo Martin Calero, Cecilia Inés Albores, Pablo Baraldo Victorica, Luis Mario Etchenique, Roberto
author_sort	Zayat, Leonardo Martin
title	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_short	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_full	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_fullStr	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_full_unstemmed	A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage
title_sort	new strategy for neurochemical photodelivery: metal-ligand heterolytic cleavage
publishDate	2003
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00027863_v125_n4_p882_Zayat http://hdl.handle.net/20.500.12110/paper_00027863_v125_n4_p882_Zayat
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A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage

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