Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina
Rodents are well-known hosts of Trypanosoma cruzi but little is known on the role of some caviomorph rodents. We assessed the occurrence and prevalence of T. cruzi infection in Microcavia australis ("southern mountain, desert or small cavy") and its infectiousness to the vector Triatoma in...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v142_n_p34_Cecere http://hdl.handle.net/20.500.12110/paper_0001706X_v142_n_p34_Cecere |
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paper:paper_0001706X_v142_n_p34_Cecere2023-06-08T14:21:15Z Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina Cavies Infectiousness Molecular diagnosis Trypanosoma cruzi disease vector host infectious disease parasite rodent rural area trypanosomiasis adult Argentina Article blood sampling body mass Chagas disease controlled study cross-sectional study disease association DNA structure female gene amplification habitat host competence host parasite interaction hyper variable region juvenile kinetoplast male Microcavia australis nonhuman parasite detection parasite examination parasite prevalence parasite transmission parasite virulence polymerase chain reaction rodent rural area Triatoma infestans Trypanosoma cruzi xenodiagnosis animal Chagas disease clinical trial disease carrier genetics human isolation and purification multicenter study parasitology prevalence rodent Rodent Diseases rural population transmission Trypanosoma cruzi veterinary zoonosis Argentina Tafi del Valle Tucuman Caviidae Microcavia australis Rodentia Trypanosoma cruzi kinetoplast DNA Animals Argentina Chagas Disease Cross-Sectional Studies Disease Vectors DNA, Kinetoplast Female Humans Male Polymerase Chain Reaction Prevalence Rodent Diseases Rodentia Rural Population Trypanosoma cruzi Zoonoses Rodents are well-known hosts of Trypanosoma cruzi but little is known on the role of some caviomorph rodents. We assessed the occurrence and prevalence of T. cruzi infection in Microcavia australis ("southern mountain, desert or small cavy") and its infectiousness to the vector Triatoma infestans in four rural communities of Tafí del Valle department, northwestern Argentina. Parasite detection was performed by xenodiagnosis and polymerase chain reaction amplification of the hyper-variable region of kinetoplast DNA minicircles of T. cruzi (kDNA-PCR) from blood samples. A total of 51 cavies was captured in traps set up along cavy paths in peridomestic dry-shrub fences located between 25 and 85. m from the nearest domicile. We document the first record of M. australis naturally infected by T. cruzi. Cavies presented a very high prevalence of infection (46.3%; 95% confidence interval, CI. = 33.0-59.6%). Only one (4%) of 23 cavies negative by xenodiagnosis was found infected by kDNA-PCR. TcI was the only discrete typing unit identified in 12 cavies with a positive xenodiagnosis. The infectiousness to T. infestans of cavies positive by xenodiagnosis or kDNA-PCR was very high (mean, 55.8%; CI. = 48.4-63.1%) and exceeded 80% in 44% of the hosts. Cavies are highly-competent hosts of T. cruzi in peridomestic habitats near human dwellings in rural communities of Tucumán province in northwestern Argentina. © 2014. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v142_n_p34_Cecere http://hdl.handle.net/20.500.12110/paper_0001706X_v142_n_p34_Cecere |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cavies Infectiousness Molecular diagnosis Trypanosoma cruzi disease vector host infectious disease parasite rodent rural area trypanosomiasis adult Argentina Article blood sampling body mass Chagas disease controlled study cross-sectional study disease association DNA structure female gene amplification habitat host competence host parasite interaction hyper variable region juvenile kinetoplast male Microcavia australis nonhuman parasite detection parasite examination parasite prevalence parasite transmission parasite virulence polymerase chain reaction rodent rural area Triatoma infestans Trypanosoma cruzi xenodiagnosis animal Chagas disease clinical trial disease carrier genetics human isolation and purification multicenter study parasitology prevalence rodent Rodent Diseases rural population transmission Trypanosoma cruzi veterinary zoonosis Argentina Tafi del Valle Tucuman Caviidae Microcavia australis Rodentia Trypanosoma cruzi kinetoplast DNA Animals Argentina Chagas Disease Cross-Sectional Studies Disease Vectors DNA, Kinetoplast Female Humans Male Polymerase Chain Reaction Prevalence Rodent Diseases Rodentia Rural Population Trypanosoma cruzi Zoonoses |
| spellingShingle |
Cavies Infectiousness Molecular diagnosis Trypanosoma cruzi disease vector host infectious disease parasite rodent rural area trypanosomiasis adult Argentina Article blood sampling body mass Chagas disease controlled study cross-sectional study disease association DNA structure female gene amplification habitat host competence host parasite interaction hyper variable region juvenile kinetoplast male Microcavia australis nonhuman parasite detection parasite examination parasite prevalence parasite transmission parasite virulence polymerase chain reaction rodent rural area Triatoma infestans Trypanosoma cruzi xenodiagnosis animal Chagas disease clinical trial disease carrier genetics human isolation and purification multicenter study parasitology prevalence rodent Rodent Diseases rural population transmission Trypanosoma cruzi veterinary zoonosis Argentina Tafi del Valle Tucuman Caviidae Microcavia australis Rodentia Trypanosoma cruzi kinetoplast DNA Animals Argentina Chagas Disease Cross-Sectional Studies Disease Vectors DNA, Kinetoplast Female Humans Male Polymerase Chain Reaction Prevalence Rodent Diseases Rodentia Rural Population Trypanosoma cruzi Zoonoses Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| topic_facet |
Cavies Infectiousness Molecular diagnosis Trypanosoma cruzi disease vector host infectious disease parasite rodent rural area trypanosomiasis adult Argentina Article blood sampling body mass Chagas disease controlled study cross-sectional study disease association DNA structure female gene amplification habitat host competence host parasite interaction hyper variable region juvenile kinetoplast male Microcavia australis nonhuman parasite detection parasite examination parasite prevalence parasite transmission parasite virulence polymerase chain reaction rodent rural area Triatoma infestans Trypanosoma cruzi xenodiagnosis animal Chagas disease clinical trial disease carrier genetics human isolation and purification multicenter study parasitology prevalence rodent Rodent Diseases rural population transmission Trypanosoma cruzi veterinary zoonosis Argentina Tafi del Valle Tucuman Caviidae Microcavia australis Rodentia Trypanosoma cruzi kinetoplast DNA Animals Argentina Chagas Disease Cross-Sectional Studies Disease Vectors DNA, Kinetoplast Female Humans Male Polymerase Chain Reaction Prevalence Rodent Diseases Rodentia Rural Population Trypanosoma cruzi Zoonoses |
| description |
Rodents are well-known hosts of Trypanosoma cruzi but little is known on the role of some caviomorph rodents. We assessed the occurrence and prevalence of T. cruzi infection in Microcavia australis ("southern mountain, desert or small cavy") and its infectiousness to the vector Triatoma infestans in four rural communities of Tafí del Valle department, northwestern Argentina. Parasite detection was performed by xenodiagnosis and polymerase chain reaction amplification of the hyper-variable region of kinetoplast DNA minicircles of T. cruzi (kDNA-PCR) from blood samples. A total of 51 cavies was captured in traps set up along cavy paths in peridomestic dry-shrub fences located between 25 and 85. m from the nearest domicile. We document the first record of M. australis naturally infected by T. cruzi. Cavies presented a very high prevalence of infection (46.3%; 95% confidence interval, CI. = 33.0-59.6%). Only one (4%) of 23 cavies negative by xenodiagnosis was found infected by kDNA-PCR. TcI was the only discrete typing unit identified in 12 cavies with a positive xenodiagnosis. The infectiousness to T. infestans of cavies positive by xenodiagnosis or kDNA-PCR was very high (mean, 55.8%; CI. = 48.4-63.1%) and exceeded 80% in 44% of the hosts. Cavies are highly-competent hosts of T. cruzi in peridomestic habitats near human dwellings in rural communities of Tucumán province in northwestern Argentina. © 2014. |
| title |
Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| title_short |
Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| title_full |
Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| title_fullStr |
Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| title_full_unstemmed |
Microcavia australis (Caviidae, Rodentia), a new highly competent host of Trypanosoma cruzi I in rural communities of northwestern Argentina |
| title_sort |
microcavia australis (caviidae, rodentia), a new highly competent host of trypanosoma cruzi i in rural communities of northwestern argentina |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v142_n_p34_Cecere http://hdl.handle.net/20.500.12110/paper_0001706X_v142_n_p34_Cecere |
| _version_ |
1768543255100653568 |