Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales
We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 micr...
Guardado en:
| Publicado: |
2014
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v140_n_p10_Fernandez http://hdl.handle.net/20.500.12110/paper_0001706X_v140_n_p10_Fernandez |
| Aporte de: |
| id |
paper:paper_0001706X_v140_n_p10_Fernandez |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_0001706X_v140_n_p10_Fernandez2023-06-08T14:21:14Z Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales Discrete typing units Diversity Molecular epidemiology Triatoma infestans Trypanosoma cruzi biodiversity disease prevalence disease transmission epidemiology geographical variation molecular ecology parasite parasite infestation protozoan rural area spatial analysis animal cell Argentina article Bolivia chicken Chile controlled study correspondence analysis cross-sectional study discrete typing unit dog geographical variation (species) goat human infestation molecular genetics nonhuman Paraguay parasite transmission parasite vector prevalence rural population species diversity species identification Triatoma infestans Trypanosoma cruzi animal biodiversity Chagas disease disease carrier isolation and purification parasitology Triatoma Trypanosoma cruzi Article genotype geographic distribution molecular epidemiology molecular typing polymerase chain reaction population distribution population dynamics population structure seasonal variation Argentina Bolivia Chaco [Argentina] Chile Paraguay Santiago del Estero [Argentina] Animals Argentina Biodiversity Bolivia Chagas Disease Chile Cross-Sectional Studies Humans Insect Vectors Paraguay Rural Population Triatoma Trypanosoma cruzi Triatoma infestans Trypanosoma cruzi We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 microscope-positive T. infestans collected in rural communities in Santiago del Estero province in northern Argentina. TcV was more often found in communities with higher house infestation prevalence compatible with active vector-borne transmission. Humans and dogs were the main bloodmeal sources of the TcV- and TcVI-infected bugs. At a broader scale, the greatest variation in DTU diversity was found within the Argentine Chaco (227 microscope-positive bugs), mainly related to differences in equitability between TcVI and TcV among study areas. At a country-wide level, a meta-analysis of published data revealed clear geographic variations in the distribution of DTUs across countries. A correspondence analysis showed that DTU distributions in domestic T. infestans were more similar within Argentina (dominated by TcVI) and within Bolivia (where TcI and TcV had similar relative frequencies), whereas large heterogeneity was found within Chile. DTU diversity was lower in the western Argentine Chaco region and Paraguay (D= 0.14-0.22) than in the eastern Argentine Chaco, Bolivia and Chile (D= 0.20-0.68). Simultaneous DTU identifications of T. cruzi-infected hosts and triatomines across areas differing in epidemiological status are needed to shed new light on the structure and dynamics of parasite transmission cycles. © 2014 Elsevier B.V. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v140_n_p10_Fernandez http://hdl.handle.net/20.500.12110/paper_0001706X_v140_n_p10_Fernandez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Discrete typing units Diversity Molecular epidemiology Triatoma infestans Trypanosoma cruzi biodiversity disease prevalence disease transmission epidemiology geographical variation molecular ecology parasite parasite infestation protozoan rural area spatial analysis animal cell Argentina article Bolivia chicken Chile controlled study correspondence analysis cross-sectional study discrete typing unit dog geographical variation (species) goat human infestation molecular genetics nonhuman Paraguay parasite transmission parasite vector prevalence rural population species diversity species identification Triatoma infestans Trypanosoma cruzi animal biodiversity Chagas disease disease carrier isolation and purification parasitology Triatoma Trypanosoma cruzi Article genotype geographic distribution molecular epidemiology molecular typing polymerase chain reaction population distribution population dynamics population structure seasonal variation Argentina Bolivia Chaco [Argentina] Chile Paraguay Santiago del Estero [Argentina] Animals Argentina Biodiversity Bolivia Chagas Disease Chile Cross-Sectional Studies Humans Insect Vectors Paraguay Rural Population Triatoma Trypanosoma cruzi Triatoma infestans Trypanosoma cruzi |
| spellingShingle |
Discrete typing units Diversity Molecular epidemiology Triatoma infestans Trypanosoma cruzi biodiversity disease prevalence disease transmission epidemiology geographical variation molecular ecology parasite parasite infestation protozoan rural area spatial analysis animal cell Argentina article Bolivia chicken Chile controlled study correspondence analysis cross-sectional study discrete typing unit dog geographical variation (species) goat human infestation molecular genetics nonhuman Paraguay parasite transmission parasite vector prevalence rural population species diversity species identification Triatoma infestans Trypanosoma cruzi animal biodiversity Chagas disease disease carrier isolation and purification parasitology Triatoma Trypanosoma cruzi Article genotype geographic distribution molecular epidemiology molecular typing polymerase chain reaction population distribution population dynamics population structure seasonal variation Argentina Bolivia Chaco [Argentina] Chile Paraguay Santiago del Estero [Argentina] Animals Argentina Biodiversity Bolivia Chagas Disease Chile Cross-Sectional Studies Humans Insect Vectors Paraguay Rural Population Triatoma Trypanosoma cruzi Triatoma infestans Trypanosoma cruzi Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| topic_facet |
Discrete typing units Diversity Molecular epidemiology Triatoma infestans Trypanosoma cruzi biodiversity disease prevalence disease transmission epidemiology geographical variation molecular ecology parasite parasite infestation protozoan rural area spatial analysis animal cell Argentina article Bolivia chicken Chile controlled study correspondence analysis cross-sectional study discrete typing unit dog geographical variation (species) goat human infestation molecular genetics nonhuman Paraguay parasite transmission parasite vector prevalence rural population species diversity species identification Triatoma infestans Trypanosoma cruzi animal biodiversity Chagas disease disease carrier isolation and purification parasitology Triatoma Trypanosoma cruzi Article genotype geographic distribution molecular epidemiology molecular typing polymerase chain reaction population distribution population dynamics population structure seasonal variation Argentina Bolivia Chaco [Argentina] Chile Paraguay Santiago del Estero [Argentina] Animals Argentina Biodiversity Bolivia Chagas Disease Chile Cross-Sectional Studies Humans Insect Vectors Paraguay Rural Population Triatoma Trypanosoma cruzi Triatoma infestans Trypanosoma cruzi |
| description |
We assessed the diversity and distribution of Trypanosoma cruzi discrete typing units (DTU) in Triatoma infestans populations and its association with local vector-borne transmission levels at various geographic scales. At a local scale, we found high predominance (92.4%) of TcVI over TcV in 68 microscope-positive T. infestans collected in rural communities in Santiago del Estero province in northern Argentina. TcV was more often found in communities with higher house infestation prevalence compatible with active vector-borne transmission. Humans and dogs were the main bloodmeal sources of the TcV- and TcVI-infected bugs. At a broader scale, the greatest variation in DTU diversity was found within the Argentine Chaco (227 microscope-positive bugs), mainly related to differences in equitability between TcVI and TcV among study areas. At a country-wide level, a meta-analysis of published data revealed clear geographic variations in the distribution of DTUs across countries. A correspondence analysis showed that DTU distributions in domestic T. infestans were more similar within Argentina (dominated by TcVI) and within Bolivia (where TcI and TcV had similar relative frequencies), whereas large heterogeneity was found within Chile. DTU diversity was lower in the western Argentine Chaco region and Paraguay (D= 0.14-0.22) than in the eastern Argentine Chaco, Bolivia and Chile (D= 0.20-0.68). Simultaneous DTU identifications of T. cruzi-infected hosts and triatomines across areas differing in epidemiological status are needed to shed new light on the structure and dynamics of parasite transmission cycles. © 2014 Elsevier B.V. |
| title |
Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| title_short |
Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| title_full |
Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| title_fullStr |
Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| title_full_unstemmed |
Geographic variation of Trypanosoma cruzi discrete typing units from Triatoma infestans at different spatial scales |
| title_sort |
geographic variation of trypanosoma cruzi discrete typing units from triatoma infestans at different spatial scales |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0001706X_v140_n_p10_Fernandez http://hdl.handle.net/20.500.12110/paper_0001706X_v140_n_p10_Fernandez |
| _version_ |
1768542339979018240 |