Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics
The possible influence of qualitative dietary changes on carbohydrate tolerance and plasma lipid levels of non insulin-dependent diabetics was studied in 5 maturity-onset diabetics of normal weight who remained stabilized with 5 to 10 mg glibenclamide. Each patient was submitted to 4 isocaloric qual...
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1974
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015563_v11_n6_p468_Senderey http://hdl.handle.net/20.500.12110/paper_00015563_v11_n6_p468_Senderey |
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paper:paper_00015563_v11_n6_p468_Senderey2023-06-08T14:20:53Z Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics Glibenclamide Glucose tolerance Influence of diet Plasma lipids Stable maturityonset diabetes fat fatty acid glibenclamide insulin lipoprotein low density lipoprotein protein triacylglycerol carbohydrate tolerance clinical trial controlled study diabetes mellitus diet fatty acid blood level glucose blood level glucose tolerance test human lipid blood level major clinical study oral drug administration randomized controlled trial theoretical study urea urine level Adult Aged Blood Glucose Diabetes Mellitus Diet Dietary Carbohydrates Dietary Fats Dietary Proteins Fasting Fatty Acids, Nonesterified Glucose Tolerance Test Human Lipids Lipoproteins Male Middle Age Triglycerides The possible influence of qualitative dietary changes on carbohydrate tolerance and plasma lipid levels of non insulin-dependent diabetics was studied in 5 maturity-onset diabetics of normal weight who remained stabilized with 5 to 10 mg glibenclamide. Each patient was submitted to 4 isocaloric qualitatively different diets: standard, high carbohydrate, high fat, and high protein. Each diet was administered for 30 consecutive days in random order. Apart from assessing metabolic control, an oral glucose tolerance test (40 g/m2 body surface area) was performed in the morning, at the end of each period. Blood was collected at 0, 60, 120, and 180 min after starting glucose ingestion, for blood glucose and plasma FFA determinations. Fasting total lipids, triglycerides, lipoalbumins, and α- and β-lipoproteins, and 24-h urinary urea were also investigated. The findings did not disclose any differences in carbohydrate tolerance after the various diets. The drop in FFA levels following an oral glucose load was greatest after the high protein diet. Fasting total lipids were lowest after the high fat and high protein diets. Triglycerides fell after the high fat diet. The remaining parameters showed less significant variations. Although no differences were observed in carbohydrate tolerance, the conclusion is that relative carbohydrate restriction together with sufficient protein supply might be most beneficial for non insulin-dependent diabetics. © 1974 The Publishing House «IL PONTE». 1974 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015563_v11_n6_p468_Senderey http://hdl.handle.net/20.500.12110/paper_00015563_v11_n6_p468_Senderey |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Glibenclamide Glucose tolerance Influence of diet Plasma lipids Stable maturityonset diabetes fat fatty acid glibenclamide insulin lipoprotein low density lipoprotein protein triacylglycerol carbohydrate tolerance clinical trial controlled study diabetes mellitus diet fatty acid blood level glucose blood level glucose tolerance test human lipid blood level major clinical study oral drug administration randomized controlled trial theoretical study urea urine level Adult Aged Blood Glucose Diabetes Mellitus Diet Dietary Carbohydrates Dietary Fats Dietary Proteins Fasting Fatty Acids, Nonesterified Glucose Tolerance Test Human Lipids Lipoproteins Male Middle Age Triglycerides |
| spellingShingle |
Glibenclamide Glucose tolerance Influence of diet Plasma lipids Stable maturityonset diabetes fat fatty acid glibenclamide insulin lipoprotein low density lipoprotein protein triacylglycerol carbohydrate tolerance clinical trial controlled study diabetes mellitus diet fatty acid blood level glucose blood level glucose tolerance test human lipid blood level major clinical study oral drug administration randomized controlled trial theoretical study urea urine level Adult Aged Blood Glucose Diabetes Mellitus Diet Dietary Carbohydrates Dietary Fats Dietary Proteins Fasting Fatty Acids, Nonesterified Glucose Tolerance Test Human Lipids Lipoproteins Male Middle Age Triglycerides Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| topic_facet |
Glibenclamide Glucose tolerance Influence of diet Plasma lipids Stable maturityonset diabetes fat fatty acid glibenclamide insulin lipoprotein low density lipoprotein protein triacylglycerol carbohydrate tolerance clinical trial controlled study diabetes mellitus diet fatty acid blood level glucose blood level glucose tolerance test human lipid blood level major clinical study oral drug administration randomized controlled trial theoretical study urea urine level Adult Aged Blood Glucose Diabetes Mellitus Diet Dietary Carbohydrates Dietary Fats Dietary Proteins Fasting Fatty Acids, Nonesterified Glucose Tolerance Test Human Lipids Lipoproteins Male Middle Age Triglycerides |
| description |
The possible influence of qualitative dietary changes on carbohydrate tolerance and plasma lipid levels of non insulin-dependent diabetics was studied in 5 maturity-onset diabetics of normal weight who remained stabilized with 5 to 10 mg glibenclamide. Each patient was submitted to 4 isocaloric qualitatively different diets: standard, high carbohydrate, high fat, and high protein. Each diet was administered for 30 consecutive days in random order. Apart from assessing metabolic control, an oral glucose tolerance test (40 g/m2 body surface area) was performed in the morning, at the end of each period. Blood was collected at 0, 60, 120, and 180 min after starting glucose ingestion, for blood glucose and plasma FFA determinations. Fasting total lipids, triglycerides, lipoalbumins, and α- and β-lipoproteins, and 24-h urinary urea were also investigated. The findings did not disclose any differences in carbohydrate tolerance after the various diets. The drop in FFA levels following an oral glucose load was greatest after the high protein diet. Fasting total lipids were lowest after the high fat and high protein diets. Triglycerides fell after the high fat diet. The remaining parameters showed less significant variations. Although no differences were observed in carbohydrate tolerance, the conclusion is that relative carbohydrate restriction together with sufficient protein supply might be most beneficial for non insulin-dependent diabetics. © 1974 The Publishing House «IL PONTE». |
| title |
Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| title_short |
Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| title_full |
Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| title_fullStr |
Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| title_full_unstemmed |
Effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| title_sort |
effects of diet composition on glucose tolerance and plasma lipids of non insulin-dependent diabetics |
| publishDate |
1974 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00015563_v11_n6_p468_Senderey http://hdl.handle.net/20.500.12110/paper_00015563_v11_n6_p468_Senderey |
| _version_ |
1768545351200931840 |