Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina

Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the...

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Autores principales: Urueña, Analía, Micone, Paula, Magneres, María Cecilia, McGovern, Ian, Mould-Quevedo, Joaquín, Rocha Sarmento, Túlio Tadeu, Giglio, Norberto
Formato: Artículo
Lenguaje:Inglés
Publicado: 2024
Materias:
Influenza
Vacunas
Costo efectividad
Vacuna basada en células
Acceso en línea:https://doi.org/10.3390/vaccines10101627
http://repositorio.isalud.edu.ar/xmlui/handle/123456789/2044
https://www.mdpi.com/2076-393X/10/10/1627
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Repositorio Institucional Digital (RID ISALUD) de Universidad ISALUD
id I92-R382-123456789-2044
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spelling I92-R382-123456789-20442024-10-31T06:00:58Z Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina Urueña, Analía Micone, Paula Magneres, María Cecilia McGovern, Ian Mould-Quevedo, Joaquín Rocha Sarmento, Túlio Tadeu Giglio, Norberto Influenza Vacunas Costo efectividad Vacuna basada en células Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons. Fil: Urueña A. Centro de Estudios para la Prevención y Control de Enfermedades Transmisibles, Universidad Isalud, Venezuela 931, Ciudad Autónoma de Buenos Aires C1095AAS, Argentina 2024-10-30T20:29:13Z 2024-10-30T20:29:13Z 2022 Article Urueña A, Micone P, Magneres MC, McGovern I, Mould-Quevedo J, Sarmento TTR, Giglio N. Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina. Vaccines. 2022; 10(10):1627. https://doi.org/10.3390/vaccines10101627 https://doi.org/10.3390/vaccines10101627 http://repositorio.isalud.edu.ar/xmlui/handle/123456789/2044 https://www.mdpi.com/2076-393X/10/10/1627 en application/pdf
institution Universidad ISALUD
institution_str I-92
repository_str R-382
collection Repositorio Institucional Digital (RID ISALUD)
language Inglés
topic Influenza
Vacunas
Costo efectividad
Vacuna basada en células
spellingShingle Influenza
Vacunas
Costo efectividad
Vacuna basada en células
Urueña, Analía
Micone, Paula
Magneres, María Cecilia
McGovern, Ian
Mould-Quevedo, Joaquín
Rocha Sarmento, Túlio Tadeu
Giglio, Norberto
Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
topic_facet Influenza
Vacunas
Costo efectividad
Vacuna basada en células
description Background: Quadrivalent cell-based influenza vaccines (QIVc) avoid egg-adaptive mutations and can be more effective than traditional quadrivalent egg-based influenza vaccines (QIVe). This analysis compared the cost-effectiveness of QIVc and QIVe in Argentinian populations < 65 years old from the payer and societal perspectives. Methods: A static decision tree model compared the costs and health benefits of vaccination with QIVc vs. QIVe using a one-year time horizon. The relative vaccine effectiveness of QIVc vs. QIVe was assumed to be 8.1% for children and 11.4% for adults. An alternative high egg-adaptation scenario was also assessed. Model inputs were sourced from Argentina or the international literature. Deterministic and probabilistic sensitivity analyses were performed. Results: Compared to QIVe, QIVc would prevent 17,857 general practitioner visits, 2418 complications, 816 hospitalizations, and 12 deaths per year. From the payers’ perspective, the incremental cost-effectiveness ratio per quality-adjusted life years gained was USD12,214 in the base case and USD2311 in the high egg-adaptation scenario. QIVc was cost-saving from the societal perspective in both scenarios. Conclusions: QIVc in Argentina would be cost-effective relative to QIVe. The potential health benefits and savings would be even higher in high egg-adaptation seasons.
format Article
author Urueña, Analía
Micone, Paula
Magneres, María Cecilia
McGovern, Ian
Mould-Quevedo, Joaquín
Rocha Sarmento, Túlio Tadeu
Giglio, Norberto
author_facet Urueña, Analía
Micone, Paula
Magneres, María Cecilia
McGovern, Ian
Mould-Quevedo, Joaquín
Rocha Sarmento, Túlio Tadeu
Giglio, Norberto
author_sort Urueña, Analía
title Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
title_short Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
title_full Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
title_fullStr Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
title_full_unstemmed Cost-Effectiveness Analysis of Cell Versus Egg-Based Seasonal Influenza Vaccination in Children and Adults in Argentina
title_sort cost-effectiveness analysis of cell versus egg-based seasonal influenza vaccination in children and adults in argentina
publishDate 2024
url https://doi.org/10.3390/vaccines10101627
http://repositorio.isalud.edu.ar/xmlui/handle/123456789/2044
https://www.mdpi.com/2076-393X/10/10/1627
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