Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery

Synthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT...

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Autores principales: Cuello, Natalia, Elías, Verónica, Mendieta, Silvia, Longhi, María, Oliva, Marcos Iván, Crivello, Mónica, Eimer, Griselda Alejandra
Formato: Documento de conferencia publisherVersion
Lenguaje:Inglés
Inglés
Publicado: 2022
Materias:
Hydrothermal treatment
MCM-41
Drug release
Indomethacin
Acceso en línea:http://hdl.handle.net/20.500.12272/6460
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-6460
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
Inglés
topic Hydrothermal treatment
MCM-41
Drug release
Indomethacin
spellingShingle Hydrothermal treatment
MCM-41
Drug release
Indomethacin
Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
topic_facet Hydrothermal treatment
MCM-41
Drug release
Indomethacin
description Synthesis of MCM-41 having magnetic elements embedded inside has been researched in order to develop very interesting drug-delivery systems. In this work, MCM-41 nanostructured materials modified with iron were synthesized using the direct synthesis method (DI) and a hydrothermal treatment (HT) was applied [1]. Due to that silanol groups can form hydrogen bridge bonds with the carboxyl and carbonyl groups of indomethacin (IN), the silanol groups density on the support was analyzed by IR spectroscopy. Then, the drug was incorporated into both iron modified samples and into the pure MCM-41 and their release profiles were evaluated "in vitro" using simulated body fluid as medium. All modified materials have faster profiles than the pure silica matrix. This could be due to the presence of nanospecies of oxides inside channels that might increase the steric diffusion resistance. Thus, the drug could diffuse through the channels of the modified material with less freedom that through those of MCM-41. However, the sample modified with iron by this method with HT have a behavior similar to that of MCM-41 possibly due to the refiner effect of HT on the nanospecies size. In addition, materials with HT have an increased availability of silanol groups capable to interact with the indomethacin. This would explain their high drug adsorption capacity and the slow drug release rate. Then, this solid have good properties of adsorption and release, similar to that of the parent pure MCM-41 and simultaneously their modification with iron nanospecies leads to materials with superparamagnetic behavior.
format Documento de conferencia
publisherVersion
author Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
author_facet Cuello, Natalia
Elías, Verónica
Mendieta, Silvia
Longhi, María
Oliva, Marcos Iván
Crivello, Mónica
Eimer, Griselda Alejandra
author_sort Cuello, Natalia
title Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_short Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_full Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_fullStr Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_full_unstemmed Effect of hydrothermal treatment on the materials MCM-41 type modified iron for drug delivery
title_sort effect of hydrothermal treatment on the materials mcm-41 type modified iron for drug delivery
publishDate 2022
url http://hdl.handle.net/20.500.12272/6460
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