RXR expression in marine gastropods with different sensitivity to imposex development

The superposition of male sexual characteristics in female marine gastropods (imposex) represents one of the clearest ecological examples of organotin-mediated endocrine disruption. Recent evidences suggest that signaling pathways mediated by members of the nuclear receptor superfamily, RXR and...

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Autores principales: Giulianelli, Sebastián, Primost, Mónica A., Lanari, Claudia, Bigatti, Gregorio
Formato: Artículo publisherVersion
Lenguaje:Inglés
Publicado: Nature 2022
Materias:
Marine gastropods
Endocrine
Acceso en línea:https://doi.org/10.1038/s41598-020-66402-1
http://hdl.handle.net/20.500.12272/6154
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-6154
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic Marine gastropods
Endocrine
spellingShingle Marine gastropods
Endocrine
Giulianelli, Sebastián
Primost, Mónica A.
Lanari, Claudia
Bigatti, Gregorio
RXR expression in marine gastropods with different sensitivity to imposex development
topic_facet Marine gastropods
Endocrine
description The superposition of male sexual characteristics in female marine gastropods (imposex) represents one of the clearest ecological examples of organotin-mediated endocrine disruption. Recent evidences suggest that signaling pathways mediated by members of the nuclear receptor superfamily, RXR and PPARγ, are involved in the development of this pseudohermaphroditic condition. Here, we identifed signifcant diferences in RXR expression in two caenogastropod species from Nuevo Gulf, Argentina, Buccinanops globulosus and Trophon geversianus, which present clear contrast in imposex incidence. In addition, B. globulosus males from a polluted and an unpolluted area showed diferences in RXR expression. Conversely, PPARγ levels were similar between both analyzed species. These fndings indicate specie-specifc RXR and PPARγ expression, suggesting a major role of RXR in the induction of imposex.
format Artículo
publisherVersion
author Giulianelli, Sebastián
Primost, Mónica A.
Lanari, Claudia
Bigatti, Gregorio
author_facet Giulianelli, Sebastián
Primost, Mónica A.
Lanari, Claudia
Bigatti, Gregorio
author_sort Giulianelli, Sebastián
title RXR expression in marine gastropods with different sensitivity to imposex development
title_short RXR expression in marine gastropods with different sensitivity to imposex development
title_full RXR expression in marine gastropods with different sensitivity to imposex development
title_fullStr RXR expression in marine gastropods with different sensitivity to imposex development
title_full_unstemmed RXR expression in marine gastropods with different sensitivity to imposex development
title_sort rxr expression in marine gastropods with different sensitivity to imposex development
publisher Nature
publishDate 2022
url https://doi.org/10.1038/s41598-020-66402-1
http://hdl.handle.net/20.500.12272/6154
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AT lanariclaudia rxrexpressioninmarinegastropodswithdifferentsensitivitytoimposexdevelopment
AT bigattigregorio rxrexpressioninmarinegastropodswithdifferentsensitivitytoimposexdevelopment
bdutipo_str Repositorios
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