Characterization of SARS-CoV-2 Dynamics in the Host

While many epidemiological models were proposed to understand and handle COVID-19 pandemic, too little has been invested to understand human viral replication and the potential use of novel antivirals to tackle the infection. In this work, using a control theoretical approach, validated mathematical...

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Detalles Bibliográficos
Autores principales: Abuin, Pablo, Anderson, Alejandro, Ferramosca, Antonio, Hernandez - Vargas, González, Alejandro
Formato: Artículo publisherVersion
Lenguaje:Inglés
Publicado: 2021
Materias:
EQUILIBRIUM SETS CHARACTERIZATION , IN-HOST MODEL , SARS-COV-2 INFECTION , STABILITY ANALYSIS , COVID-19
Acceso en línea:http://hdl.handle.net/20.500.12272/4873
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-4873
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic EQUILIBRIUM SETS CHARACTERIZATION , IN-HOST MODEL , SARS-COV-2 INFECTION , STABILITY ANALYSIS , COVID-19
spellingShingle EQUILIBRIUM SETS CHARACTERIZATION , IN-HOST MODEL , SARS-COV-2 INFECTION , STABILITY ANALYSIS , COVID-19
Abuin, Pablo
Anderson, Alejandro
Ferramosca, Antonio
Hernandez - Vargas
González, Alejandro
Characterization of SARS-CoV-2 Dynamics in the Host
topic_facet EQUILIBRIUM SETS CHARACTERIZATION , IN-HOST MODEL , SARS-COV-2 INFECTION , STABILITY ANALYSIS , COVID-19
description While many epidemiological models were proposed to understand and handle COVID-19 pandemic, too little has been invested to understand human viral replication and the potential use of novel antivirals to tackle the infection. In this work, using a control theoretical approach, validated mathematical models of SARS-CoV-2 in humans are characterized. A complete analysis of the main dynamic characteristic is developed based on the reproduction number. The equilibrium regions of the system are fully characterized, and the stability of such regions is formally established. Mathematical analysis highlights critical conditions to decrease monotonically SARS-CoV-2 in the host, as such conditions are relevant to tailor future antiviral treatments. Simulation results show the aforementioned system characterization.
format Artículo
publisherVersion
author Abuin, Pablo
Anderson, Alejandro
Ferramosca, Antonio
Hernandez - Vargas
González, Alejandro
author_facet Abuin, Pablo
Anderson, Alejandro
Ferramosca, Antonio
Hernandez - Vargas
González, Alejandro
author_sort Abuin, Pablo
title Characterization of SARS-CoV-2 Dynamics in the Host
title_short Characterization of SARS-CoV-2 Dynamics in the Host
title_full Characterization of SARS-CoV-2 Dynamics in the Host
title_fullStr Characterization of SARS-CoV-2 Dynamics in the Host
title_full_unstemmed Characterization of SARS-CoV-2 Dynamics in the Host
title_sort characterization of sars-cov-2 dynamics in the host
publishDate 2021
url http://hdl.handle.net/20.500.12272/4873
work_keys_str_mv AT abuinpablo characterizationofsarscov2dynamicsinthehost
AT andersonalejandro characterizationofsarscov2dynamicsinthehost
AT ferramoscaantonio characterizationofsarscov2dynamicsinthehost
AT hernandezvargas characterizationofsarscov2dynamicsinthehost
AT gonzalezalejandro characterizationofsarscov2dynamicsinthehost
bdutipo_str Repositorios
_version_ 1764820552251342848

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