Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs

Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethy...

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Detalles Bibliográficos
Autores principales: Faccia, Paula, Pardini, Francisco, Amalvy, Javier
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2019
Materias:
Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
Acceso en línea:http://hdl.handle.net/20.500.12272/3408
Aporte de:
RIA - Repositorio Institucional Abierto (UTN) de Universidad Tecnológica Nacional
id I68-R174-20.500.12272-3408
record_format dspace
institution Universidad Tecnológica Nacional
institution_str I-68
repository_str R-174
collection RIA - Repositorio Institucional Abierto (UTN)
language Inglés
topic Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
spellingShingle Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
Faccia, Paula
Pardini, Francisco
Amalvy, Javier
Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
topic_facet Smart polymers; 2-hydroxyethyl methacrylate; 2-(diisoproylamino)ethyl 36 methacrylate; pH-sensitive hydrogels; drug delivery systems
description Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH- sensitive drug delivery system for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by FTIR spectroscopy and SEM. The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.
format Artículo
publishedVersion
Artículo
author Faccia, Paula
Pardini, Francisco
Amalvy, Javier
author_facet Faccia, Paula
Pardini, Francisco
Amalvy, Javier
author_sort Faccia, Paula
title Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_short Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_full Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_fullStr Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_full_unstemmed Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
title_sort evaluation of ph-sensitive poly(2-hydroxyethyl methacrylate-co-2- (diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs
publishDate 2019
url http://hdl.handle.net/20.500.12272/3408
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