Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography
Fil: Avendaño, Maria Eugenia. Universidad Nacional de Cuyo
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| Lenguaje: | Inglés |
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2020
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| Acceso en línea: | http://rid.unrn.edu.ar/handle/20.500.12049/10100 |
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I65-R171-20.500.12049-10100 |
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I65-R171-20.500.12049-101002023-05-03T16:39:05Z application/pdf info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/4.0/ 2020-11 Fil: Avendaño, Maria Eugenia. Universidad Nacional de Cuyo Fil: Poletto, Adriana. Facultad de Odontología.Universidad Nacional de Cuyo Fil: Bonanno, Marina Soledad. INIGEM.UBA.CONICET Fil: Davison, Mario Ricardo. Universidad Nacional de Rio Negro. Río Negro; Argentina. Fil: Zeni, Susana Noemi. UBA/CONICET. Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography Avendaño, Maria Eugenia Poletto, Adriana Bonanno, Marina Soledad Davison, Mario Ricardo Zeni, Susana Noemi Ciencias Médicas y de la Salud Tomografía Hueso PTH Bifosfonatos Ciencias Médicas y de la Salud The cone-beam computed tomography (CBCT) is a non-invasive 3D reconstruction technique that enables to assess jawbone micro-architecture. It is used to illustrate results through 3D images. In the present report, the combination of CBCT with other techniques was used to evaluate changes in composition and micro-architectural structure quantity of the ewe jawbone after oestrogen withdrawal (OVX) and/or chronic treatment with high doses of zoledronic acid (zol). Three groups of adult Corriedale ewes, 35 to 40 kg body weight were used: OVX: OVX ewes receiving saline solution; ZOL: OVX ewes treated with Zol (4 mg/month) for 28 months for high cumulative dose of ZOL in bones and SHAM: SHAM ewes receiving saline solution (control). At the end of the study, hemi-mandibles were extracted: Bone mineral density (BMD) and content (BMC) of the mandibles were evaluated ex vivo by DXA (Lunar DPX); CBCT was performed using Planmeca Promax 3D Classic. Results of CBCT: OVX as compared to SHAM ewes significantly decreased BMC and BMD (p<0.001); BV/ TV (%), Tb. Th, connectivity and anisotropy (p<0.0075; p<0.0075, p<0.001 and p<0.02, respectively) while Tb. Sp (p< 0.0002) was significantly increased. Zol treatment did not show statistical differences when compared to SHAM group. Zol showed values of anisotropy significantly higher than OVX group (p<0.018) and Tb.Sp significantly lower than OVX groups (p<0.043). BV/ TV (%), Tb. Th and connectivity as compared to OVX group showed a clear tendency to be higher and almost reached significance (p=0.055; p=0.061 and p=0.054, respectively. Maxillary BMC and BMD were lowest in OVX ewes (p<0.05) and were significantly higher in ZOL than in SHAM ewes (p<0.05). Conclusion: The CBCT technique was useful to evaluate the deterioration of the bone quality by estrogen withdrawal and the recovery by ZOL treatment. http://rid.unrn.edu.ar/handle/20.500.12049/10100 en https://www.medicinabuenosaires.com/ REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020 / LXV REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACIÓN CLÍNICA (SAIC) / LXVIII REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE INMUNOLOGÍA (SAI) / REUNIÓN ANUAL DE LA SOCIEDAD ARGENTINA DE FISIOLOGÍA (SAFIS) |
| institution |
Universidad Nacional de Río Negro |
| institution_str |
I-65 |
| repository_str |
R-171 |
| collection |
Repositorio Institucional Digital de la Universidad Nacional de Río Negro (UNRN) |
| language |
Inglés |
| orig_language_str_mv |
en |
| topic |
Ciencias Médicas y de la Salud Tomografía Hueso PTH Bifosfonatos Ciencias Médicas y de la Salud |
| spellingShingle |
Ciencias Médicas y de la Salud Tomografía Hueso PTH Bifosfonatos Ciencias Médicas y de la Salud Avendaño, Maria Eugenia Poletto, Adriana Bonanno, Marina Soledad Davison, Mario Ricardo Zeni, Susana Noemi Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| topic_facet |
Ciencias Médicas y de la Salud Tomografía Hueso PTH Bifosfonatos Ciencias Médicas y de la Salud |
| description |
Fil: Avendaño, Maria Eugenia. Universidad Nacional de Cuyo |
| author |
Avendaño, Maria Eugenia Poletto, Adriana Bonanno, Marina Soledad Davison, Mario Ricardo Zeni, Susana Noemi |
| author_facet |
Avendaño, Maria Eugenia Poletto, Adriana Bonanno, Marina Soledad Davison, Mario Ricardo Zeni, Susana Noemi |
| author_sort |
Avendaño, Maria Eugenia |
| title |
Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| title_short |
Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| title_full |
Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| title_fullStr |
Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| title_full_unstemmed |
Assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| title_sort |
assessment of jawbone microarchitecture in bisphosphonate- treated sheep by cone-beam computed tomography |
| publishDate |
2020 |
| url |
http://rid.unrn.edu.ar/handle/20.500.12049/10100 |
| work_keys_str_mv |
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| _version_ |
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