Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)

Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six...

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Autores principales: Ibañez, Agustín, Urquina, Diego, Petroni, Agustín, Baez, Sandra, Lopez, Vladimir, Nascimento, Micaela do, Herrera, Eduar, Guex, Raphael, Hurtado, Esteban, Blenkmann, Esteban, Beltrachini, Leandro, Gelormini, Carlos, Sigman, Mariano, Lischinsky, Alicia, Torralva, Teresa, Torrente, Fernando, Cetkovich, Marcelo, Manes, Facundo
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2018
Materias:
Cara
Emociones
Reconocimiento (Psicología)
Trastorno bipolar
Potenciales evocados
Cognición
Pruebas neuropsicológicas
Face
Emotions
Face recognition
Bipolar disorder
Event-related potentials
Social cognition
Cognition
Neurophsychological testing
Acceso en línea:https://doi.org/10.1371/journal.pone.0046877
https://repositorio.utdt.edu/handle/20.500.13098/11083
Aporte de:
Repositorio Digital Universidad Torcuato Di Tella de Universidad Torcuato Di Tella
id I57-R16320.500.13098-11083
record_format dspace
institution Universidad Torcuato Di Tella
institution_str I-57
repository_str R-163
collection Repositorio Digital Universidad Torcuato Di Tella
language Inglés
orig_language_str_mv eng
topic Cara
Emociones
Reconocimiento (Psicología)
Trastorno bipolar
Potenciales evocados
Cognición
Pruebas neuropsicológicas
Face
Emotions
Face recognition
Bipolar disorder
Event-related potentials
Social cognition
Cognition
Neurophsychological testing
spellingShingle Cara
Emociones
Reconocimiento (Psicología)
Trastorno bipolar
Potenciales evocados
Cognición
Pruebas neuropsicológicas
Face
Emotions
Face recognition
Bipolar disorder
Event-related potentials
Social cognition
Cognition
Neurophsychological testing
Ibañez, Agustín
Urquina, Diego
Petroni, Agustín
Baez, Sandra
Lopez, Vladimir
Nascimento, Micaela do
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Esteban
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando
Cetkovich, Marcelo
Manes, Facundo
Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
description Background: Adults with bipolar disorder (BD) have cognitive impairments that affect face processing and social cognition. However, it remains unknown whether these deficits in euthymic BD have impaired brain markers of emotional processing. Methodology/Principal Findings: We recruited twenty six participants, 13 controls subjects with an equal number of euthymic BD participants. We used an event-related potential (ERP) assessment of a dual valence task (DVT), in which faces (angry and happy), words (pleasant and unpleasant), and face-word simultaneous combinations are presented to test the effects of the stimulus type (face vs word) and valence (positive vs. negative). All participants received clinical, neuropsychological and social cognition evaluations. ERP analysis revealed that both groups showed N170 modulation of stimulus type effects (face . word). BD patients exhibited reduced and enhanced N170 to facial and semantic valence, respectively. The neural source estimation of N170 was a posterior section of the fusiform gyrus (FG), including the face fusiform area (FFA). Neural generators of N170 for faces (FG and FFA) were reduced in BD. In these patients, N170 modulation was associated with social cognition (theory of mind). Conclusions/Significance: This is the first report of euthymic BD exhibiting abnormal N170 emotional discrimination associated with theory of mind impairments.
format Artículo
publishedVersion
author Ibañez, Agustín
Urquina, Diego
Petroni, Agustín
Baez, Sandra
Lopez, Vladimir
Nascimento, Micaela do
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Esteban
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando
Cetkovich, Marcelo
Manes, Facundo
author_facet Ibañez, Agustín
Urquina, Diego
Petroni, Agustín
Baez, Sandra
Lopez, Vladimir
Nascimento, Micaela do
Herrera, Eduar
Guex, Raphael
Hurtado, Esteban
Blenkmann, Esteban
Beltrachini, Leandro
Gelormini, Carlos
Sigman, Mariano
Lischinsky, Alicia
Torralva, Teresa
Torrente, Fernando
Cetkovich, Marcelo
Manes, Facundo
author_sort Ibañez, Agustín
title Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_short Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_full Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_fullStr Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_full_unstemmed Neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (BD) and its association with theory of mind (ToM)
title_sort neural processing of emotional facial and semantic xxpressions in euthymic bipolar disorder (bd) and its association with theory of mind (tom)
publishDate 2018
url https://doi.org/10.1371/journal.pone.0046877
https://repositorio.utdt.edu/handle/20.500.13098/11083
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