Organization of brain networks governed by long-range connections index autistic traits in the general population

Background: The dimensional approach to autism spectrum disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We explored the potential utility of electroencephalography (EEG) functional connectivity as a biomarker. We hypothesized that individual dif...

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Detalles Bibliográficos
Autores principales: Barttfeld, Pablo, Amoruso, Lucía, Ais, Joaquín, Cukier, Sebastián, Bavassi, Luz, Tomio, Ailin, Manes, Facundo, Ibañez, Agustín, Sigman, Mariano
Formato: Artículo publishedVersion
Lenguaje:Inglés
Publicado: 2018
Materias:
Autism spectrum disorders
Electroencephalography
Autistic traits
Synchronization likelihood
Small world
Long-range connections
Acceso en línea:https://doi.org/10.1186/1866-1955-5-16
https://repositorio.utdt.edu/handle/20.500.13098/11081
Aporte de:
Repositorio Digital Universidad Torcuato Di Tella de Universidad Torcuato Di Tella
id I57-R16320.500.13098-11081
record_format dspace
institution Universidad Torcuato Di Tella
institution_str I-57
repository_str R-163
collection Repositorio Digital Universidad Torcuato Di Tella
language Inglés
orig_language_str_mv eng
topic Autism spectrum disorders
Electroencephalography
Autistic traits
Synchronization likelihood
Small world
Long-range connections
spellingShingle Autism spectrum disorders
Electroencephalography
Autistic traits
Synchronization likelihood
Small world
Long-range connections
Barttfeld, Pablo
Amoruso, Lucía
Ais, Joaquín
Cukier, Sebastián
Bavassi, Luz
Tomio, Ailin
Manes, Facundo
Ibañez, Agustín
Sigman, Mariano
Organization of brain networks governed by long-range connections index autistic traits in the general population
description Background: The dimensional approach to autism spectrum disorder (ASD) considers ASD as the extreme of a dimension traversing through the entire population. We explored the potential utility of electroencephalography (EEG) functional connectivity as a biomarker. We hypothesized that individual differences in autistic traits of typical subjects would involve a long-range connectivity diminution within the delta band. Methods: Resting-state EEG functional connectivity was measured for 74 neurotypical subjects. All participants also provided a questionnaire (Social Responsiveness Scale, SRS) that was completed by an informant who knows the participant in social settings. We conducted multivariate regression between the SRS score and functional connectivity in all EEG frequency bands. We explored modulations of network graph metrics characterizing the optimality of a network using the SRS score. Results: Our results show a decay in functional connectivity mainly within the delta and theta bands (the lower part of the EEG spectrum) associated with an increasing number of autistic traits. When inspecting the impact of autistic traits on the global organization of the functional network, we found that the optimal properties of the network are inversely related to the number of autistic traits, suggesting that the autistic dimension, throughout the entire population, modulates the efficiency of functional brain networks. Conclusions: EEG functional connectivity at low frequencies and its associated network properties may be associated with some autistic traits in the general population.
format Artículo
publishedVersion
author Barttfeld, Pablo
Amoruso, Lucía
Ais, Joaquín
Cukier, Sebastián
Bavassi, Luz
Tomio, Ailin
Manes, Facundo
Ibañez, Agustín
Sigman, Mariano
author_facet Barttfeld, Pablo
Amoruso, Lucía
Ais, Joaquín
Cukier, Sebastián
Bavassi, Luz
Tomio, Ailin
Manes, Facundo
Ibañez, Agustín
Sigman, Mariano
author_sort Barttfeld, Pablo
title Organization of brain networks governed by long-range connections index autistic traits in the general population
title_short Organization of brain networks governed by long-range connections index autistic traits in the general population
title_full Organization of brain networks governed by long-range connections index autistic traits in the general population
title_fullStr Organization of brain networks governed by long-range connections index autistic traits in the general population
title_full_unstemmed Organization of brain networks governed by long-range connections index autistic traits in the general population
title_sort organization of brain networks governed by long-range connections index autistic traits in the general population
publishDate 2018
url https://doi.org/10.1186/1866-1955-5-16
https://repositorio.utdt.edu/handle/20.500.13098/11081
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