Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach

Background/Objectives: This systematic review evaluates unconventional mammalian models from wild, agricultural, and urban/domestic ecosystems for genotoxicity assessment under the One Health framework. Non-human primates (NHPs), cattle, and domestic dogs are analyzed as sentinel species due to thei...

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Autores principales:	Gorla, Nora Bibiana, Nieves, Mariela, Ferré, Daniela Marisol
Formato:	Artículo Científico
Lenguaje:	Inglés
Publicado:	2025
Materias:	agro ecosystems cattle wild scenarios primates homelike environment dogs contaminants genetic toxicology One Health
Acceso en línea:	https://repositorio.umaza.edu.ar/handle/00261/3565
Aporte de:	UMAZA Digital (Universidad MAZA - Mendoza) de Universidad Juan Agustín MAZA

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record_format	dspace
spelling	I56-R162-00261-35652025-07-24T02:01:01Z Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach Gorla, Nora Bibiana Nieves, Mariela Ferré, Daniela Marisol agro ecosystems cattle wild scenarios primates homelike environment dogs contaminants genetic toxicology One Health Background/Objectives: This systematic review evaluates unconventional mammalian models from wild, agricultural, and urban/domestic ecosystems for genotoxicity assessment under the One Health framework. Non-human primates (NHPs), cattle, and domestic dogs are analyzed as sentinel species due to their distinct environmental niches, unique human interactions, and species-specific traits. In conjunction with this, evidence is presented about the in vitro use of cells of these mammals for the genotoxicological evaluation of different chemical substances, such as veterinary drugs, environmental pollutants, and pesticides. The synthesis focuses on standardized genetic toxicology assays (e.g., chromosomal aberrations, micronucleus, comet assay) aligned with Organization for Economic Cooperation and Development (OECD) guidelines. Methods: A structured search of international literature identified studies employing OECD-compliant genotoxicity assays in NHPs, cattle, dogs, and others not listed in OECD. Data was categorized by species, assay type, chemical class evaluated, environmental context (wild, agricultural, urban), and merits of the papers. Results: NHPs, despite their phylogenetic proximity to humans, show limited genotoxicity data in contrast to biomedical research, which has been constrained by ethical concerns and fieldwork logistics. Cattle emerge as robust models in agricultural settings due to the abundance of studies on the genotoxic capacity of pesticides, veterinary drug, and environmental biomonitoring, with direct implications for food safety. Domestic dogs are recognized as powerful sentinels for human health due to shared exposomes, physiological similarities (e.g., shorter cancer latency), and reduced lifestyle confounders; however, genotoxicity studies in dogs remain sparse compared to chemical exposure monitoring or cancer research. Conclusions: This review advocates for expanded, integrated use of these models to address genotoxic threats across ecosystems, which would benefit both animal and human health. In the application of biomonitoring studies with sentinel animals, a critical gap persists: the frequent lack of integration between xenobiotic quantification in environmental and biological samples, along with genotoxicity biomarkers evaluation in sentinel populations, which hinders comprehensive environmental risk assessment. 2025-07-23T13:00:28Z 2025-07-23T13:00:28Z 2025 Artículo Científico Gorla, N. B. M., Nieves, M., & Ferré, D. M. (2025). Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach. Genes, 16(5), 525. https://doi.org/10.3390/genes16050525 https://repositorio.umaza.edu.ar/handle/00261/3565 eng application/pdf
institution	Universidad Juan Agustín MAZA
institution_str	I-56
repository_str	R-162
collection	UMAZA Digital (Universidad MAZA - Mendoza)
language	Inglés
orig_language_str_mv	eng
topic	agro ecosystems cattle wild scenarios primates homelike environment dogs contaminants genetic toxicology One Health
spellingShingle	agro ecosystems cattle wild scenarios primates homelike environment dogs contaminants genetic toxicology One Health Gorla, Nora Bibiana Nieves, Mariela Ferré, Daniela Marisol Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
topic_facet	agro ecosystems cattle wild scenarios primates homelike environment dogs contaminants genetic toxicology One Health
description	Background/Objectives: This systematic review evaluates unconventional mammalian models from wild, agricultural, and urban/domestic ecosystems for genotoxicity assessment under the One Health framework. Non-human primates (NHPs), cattle, and domestic dogs are analyzed as sentinel species due to their distinct environmental niches, unique human interactions, and species-specific traits. In conjunction with this, evidence is presented about the in vitro use of cells of these mammals for the genotoxicological evaluation of different chemical substances, such as veterinary drugs, environmental pollutants, and pesticides. The synthesis focuses on standardized genetic toxicology assays (e.g., chromosomal aberrations, micronucleus, comet assay) aligned with Organization for Economic Cooperation and Development (OECD) guidelines. Methods: A structured search of international literature identified studies employing OECD-compliant genotoxicity assays in NHPs, cattle, dogs, and others not listed in OECD. Data was categorized by species, assay type, chemical class evaluated, environmental context (wild, agricultural, urban), and merits of the papers. Results: NHPs, despite their phylogenetic proximity to humans, show limited genotoxicity data in contrast to biomedical research, which has been constrained by ethical concerns and fieldwork logistics. Cattle emerge as robust models in agricultural settings due to the abundance of studies on the genotoxic capacity of pesticides, veterinary drug, and environmental biomonitoring, with direct implications for food safety. Domestic dogs are recognized as powerful sentinels for human health due to shared exposomes, physiological similarities (e.g., shorter cancer latency), and reduced lifestyle confounders; however, genotoxicity studies in dogs remain sparse compared to chemical exposure monitoring or cancer research. Conclusions: This review advocates for expanded, integrated use of these models to address genotoxic threats across ecosystems, which would benefit both animal and human health. In the application of biomonitoring studies with sentinel animals, a critical gap persists: the frequent lack of integration between xenobiotic quantification in environmental and biological samples, along with genotoxicity biomarkers evaluation in sentinel populations, which hinders comprehensive environmental risk assessment.
format	Artículo Científico
author	Gorla, Nora Bibiana Nieves, Mariela Ferré, Daniela Marisol
author_facet	Gorla, Nora Bibiana Nieves, Mariela Ferré, Daniela Marisol
author_sort	Gorla, Nora Bibiana
title	Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
title_short	Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
title_full	Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
title_fullStr	Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
title_full_unstemmed	Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach
title_sort	genotoxicity in unconventional mammalian models of wild, urban, and agricultural ecosystems: a systematic review under the one health approach
publishDate	2025
url	https://repositorio.umaza.edu.ar/handle/00261/3565
work_keys_str_mv	AT gorlanorabibiana genotoxicityinunconventionalmammalianmodelsofwildurbanandagriculturalecosystemsasystematicreviewundertheonehealthapproach AT nievesmariela genotoxicityinunconventionalmammalianmodelsofwildurbanandagriculturalecosystemsasystematicreviewundertheonehealthapproach AT ferredanielamarisol genotoxicityinunconventionalmammalianmodelsofwildurbanandagriculturalecosystemsasystematicreviewundertheonehealthapproach
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Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach

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