Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos
Chlorpyrifos is an anticholinesterase organophosphate insecticide widely used in Argentina in the production of food derived from animal, fruit and horticultural origin and is reported as a residue within these products. Local reference values for acetyl and butyrylcholinesterase were determined in...
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| Formato: | Institucional - Material de Difusión |
| Lenguaje: | Inglés |
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Comité editorial Journal of Environmental Science and Health
2020
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| Acceso en línea: | http://repositorio.umaza.edu.ar//handle/00261/1834 https://pubmed.ncbi.nlm.nih.gov/29293401/ |
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I56-R162-00261-1834 |
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I56-R162-00261-18342023-08-17T22:26:15Z Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos Ferré, Daniela Marisol Lentini, Valeria Roxana Romano, Raquel Ludueña, Héctor Ricardo Jotallán, Paola Jimena Gorla, Nora Bibiana María Chlorpyrifos Cattle Chlolinesterases Renal and liver function Chlorpyrifos is an anticholinesterase organophosphate insecticide widely used in Argentina in the production of food derived from animal, fruit and horticultural origin and is reported as a residue within these products. Local reference values for acetyl and butyrylcholinesterase were determined in Aberdeen Angus bovine and cross bred cattle (n D 25), a requirement to be able to evaluate toxicity of commercial organophosphate and carbamate formulations. The activity of cholinesterase enzymes presented an overall mean of 2,183.00 § 485.6 IU L¡1 for erythrocyte acetylcholinesterase and 203.1 § 42.06 IU L¡1 for plasma butyrylcholinesterase, which are used as reference values for meat steers within a system of intensive production in a semi-arid region. The toxic potential of chlorpyrifos in steers of the same breeds (n D 12) was assessed applying chlorpyrifos 15.00% Tipertox in a single therapeutic dose of 7.50 mg kg¡1 by topical route. Prior to application and then on day 1 and day 21 post-application, both blood cholinesterases, serum chlorpyrifos concentration by ultra-high resolution liquid chromatography with mass detector, analysis of blood counts, total proteins, liver enzymes, urea and creatinine were evaluated. The mean plasma concentration of chlorpyrifos was 27.90 ug L¡1 at 24 h. The findings indicate that the therapeutic treatment of castrated male bovines treated with chlorpyrifos, applied by pour-on according to the manufacturer’s instructions, does not cause changes in the variables evaluated. 2020-11-10T21:24:39Z 2020-11-10T21:24:39Z 2018-01-02 Institucional - Material de Difusión Ferré D. M., Lentini V.R., Romano R. R., Ludueña H.R., Jotallán P.J., Gorla N. B. M. (2018) Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos. J Environ Sci Health B. 53(3):191-198. doi: 10.1080/03601234.2017.1405622. 1532-4109 http://repositorio.umaza.edu.ar//handle/00261/1834 https://pubmed.ncbi.nlm.nih.gov/29293401/ eng image/png Comité editorial Journal of Environmental Science and Health 53;3 |
| institution |
Universidad Juan Agustín MAZA |
| institution_str |
I-56 |
| repository_str |
R-162 |
| collection |
UMAZA Digital (Universidad MAZA - Mendoza) |
| language |
Inglés |
| orig_language_str_mv |
eng |
| topic |
Chlorpyrifos Cattle Chlolinesterases Renal and liver function |
| spellingShingle |
Chlorpyrifos Cattle Chlolinesterases Renal and liver function Ferré, Daniela Marisol Lentini, Valeria Roxana Romano, Raquel Ludueña, Héctor Ricardo Jotallán, Paola Jimena Gorla, Nora Bibiana María Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| topic_facet |
Chlorpyrifos Cattle Chlolinesterases Renal and liver function |
| description |
Chlorpyrifos is an anticholinesterase organophosphate insecticide widely used in Argentina in the production of food derived from animal, fruit and horticultural origin and is reported as a residue within these products. Local reference values for acetyl and butyrylcholinesterase were determined in Aberdeen Angus bovine and cross bred cattle (n D 25), a requirement to be able to evaluate toxicity of commercial organophosphate and carbamate formulations. The activity of cholinesterase enzymes presented an overall mean of 2,183.00 § 485.6 IU L¡1 for erythrocyte acetylcholinesterase and 203.1 § 42.06 IU L¡1 for
plasma butyrylcholinesterase, which are used as reference values for meat steers within a system of
intensive production in a semi-arid region. The toxic potential of chlorpyrifos in steers of the same breeds (n D 12) was assessed applying chlorpyrifos 15.00% Tipertox in a single therapeutic dose of 7.50 mg kg¡1 by topical route. Prior to application and then on day 1 and day 21 post-application, both blood cholinesterases, serum chlorpyrifos concentration by ultra-high resolution liquid chromatography with mass detector, analysis of blood counts, total proteins, liver enzymes, urea and creatinine were evaluated.
The mean plasma concentration of chlorpyrifos was 27.90 ug L¡1 at 24 h. The findings indicate that the
therapeutic treatment of castrated male bovines treated with chlorpyrifos, applied by pour-on according to the manufacturer’s instructions, does not cause changes in the variables evaluated. |
| format |
Institucional - Material de Difusión |
| author |
Ferré, Daniela Marisol Lentini, Valeria Roxana Romano, Raquel Ludueña, Héctor Ricardo Jotallán, Paola Jimena Gorla, Nora Bibiana María |
| author_facet |
Ferré, Daniela Marisol Lentini, Valeria Roxana Romano, Raquel Ludueña, Héctor Ricardo Jotallán, Paola Jimena Gorla, Nora Bibiana María |
| author_sort |
Ferré, Daniela Marisol |
| title |
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| title_short |
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| title_full |
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| title_fullStr |
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| title_full_unstemmed |
Reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| title_sort |
reference values for acetyl and butyrylcholinesterases in cattle under actual management conditions, hepatic and renal function by application of chlorpyrifos |
| publisher |
Comité editorial Journal of Environmental Science and Health |
| publishDate |
2020 |
| url |
http://repositorio.umaza.edu.ar//handle/00261/1834 https://pubmed.ncbi.nlm.nih.gov/29293401/ |
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