Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep

In sheep, traditional estrus synchronization (ES) protocols involve the insertion of a progesterone- or progestogen-containing device, followed by the administration of equine chorionic gonadotropin (eCG) at device removal to induce ovulation. Previous research evaluating estradiol benzoate (EB) as...

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Autores principales: Gómez, M. V., Soto, A. T., de la Sota, R. L.
Formato: Artículo revista
Lenguaje:Español
Publicado: Universidad Nacional del Nordeste 2025
Materias:
Estradiol benzoate dosage
GnRH
artificial insemination
sheep
benzoato de estradiol
inseminación artificial
ovinos
Acceso en línea:https://revistas.unne.edu.ar/index.php/vet/article/view/8740
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) de Universidad Nacional del Nordeste
id I48-R154-article-8740
record_format ojs
spelling I48-R154-article-87402025-09-29T21:35:32Z Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep Aplicación de benzoato de estradiol como alternativa a la gonadotrofina coriónica equina en protocolos de sincronización de celos en ovinos Gómez, M. V. Soto, A. T. de la Sota, R. L. Estradiol benzoate dosage GnRH artificial insemination sheep benzoato de estradiol GnRH inseminación artificial ovinos In sheep, traditional estrus synchronization (ES) protocols involve the insertion of a progesterone- or progestogen-containing device, followed by the administration of equine chorionic gonadotropin (eCG) at device removal to induce ovulation. Previous research evaluating estradiol benzoate (EB) as an alternative to eCG has reported low pregnancy rates. The objectives of this study were to determine (a) the optimal EB dose (100 vs. 200 μg) and timing of administration (0, 24, or 36 h after device removal) within an ES protocol (Experiments I and II), and (b) the pregnancy rate obtained using ES protocols with progesterone plus either eCG or EB, combined with fixed-time artificial insemination (FTAI; Experiment III), in ewes during the breeding season. Experiments I and II indicated that the optimal EB treatment was 100 μg administered at 0 h. In Experiment III, pregnancy rates did not differ between eCG- and EB-based ES protocols. These findings suggest that EB can replace eCG in ES protocols with FTAI at 50–55 h using fresh semen, although further research is needed to refine the timing of FTAI. con progesterona o progestágenos y la aplicación de gonadotrofina coriónica equina (eCG) al retiro del dispositivo, como inductor de la ovulación. Investigaciones basadas en el uso de benzoato de estradiol (BE) como alternativa a la eCG resultan en bajos porcentajes de preñez. El presente trabajo tuvo como objetivos determinar: a) la mejor dosis (100 vs. 200 μg) y momento de aplicación (0, 24 o 36 h del retiro del dispositivo) de BE, dentro de un PS (Experimentos I y II) y b) el porcentaje de preñez luego de la aplicación de un PS con progesterona y eCG o BE; con inseminación artificial a tiempo fijo (IATF), en ovejas durante la época reproductiva (Experimento III). Los Experimentos I y II dieron como resultado que la mejor dosis y momento de aplicación de BE fue de 100 μg y 0 h, respectivamente. En el Experimento III, el porcentaje de preñez no fue diferente entre PS eCG y PS BE. Los resultados obtenidos sugieren la posibilidad de utilizar BE en un PS con IATF a las 50-55 h con semen fresco, siendo necesarias nuevas investigaciones sobre el momento de realización de IATF con semen fresco. Universidad Nacional del Nordeste 2025-09-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/8740 10.30972/vet.3628740 Revista Veterinaria; Vol. 36 Núm. 2 (2025); 1-6 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/8740/8244 https://creativecommons.org/licenses/by-nc/4.0
institution Universidad Nacional del Nordeste
institution_str I-48
repository_str R-154
container_title_str Revistas UNNE - Universidad Nacional del Noroeste (UNNE)
language Español
format Artículo revista
topic Estradiol benzoate dosage
GnRH
artificial insemination
sheep
benzoato de estradiol
GnRH
inseminación artificial
ovinos
spellingShingle Estradiol benzoate dosage
GnRH
artificial insemination
sheep
benzoato de estradiol
GnRH
inseminación artificial
ovinos
Gómez, M. V.
Soto, A. T.
de la Sota, R. L.
Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
topic_facet Estradiol benzoate dosage
GnRH
artificial insemination
sheep
benzoato de estradiol
GnRH
inseminación artificial
ovinos
author Gómez, M. V.
Soto, A. T.
de la Sota, R. L.
author_facet Gómez, M. V.
Soto, A. T.
de la Sota, R. L.
author_sort Gómez, M. V.
title Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
title_short Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
title_full Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
title_fullStr Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
title_full_unstemmed Application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
title_sort application of estradiol benzoate as an alternative to equine chorionic gonadotropin in heat synchronization protocols in sheep
description In sheep, traditional estrus synchronization (ES) protocols involve the insertion of a progesterone- or progestogen-containing device, followed by the administration of equine chorionic gonadotropin (eCG) at device removal to induce ovulation. Previous research evaluating estradiol benzoate (EB) as an alternative to eCG has reported low pregnancy rates. The objectives of this study were to determine (a) the optimal EB dose (100 vs. 200 μg) and timing of administration (0, 24, or 36 h after device removal) within an ES protocol (Experiments I and II), and (b) the pregnancy rate obtained using ES protocols with progesterone plus either eCG or EB, combined with fixed-time artificial insemination (FTAI; Experiment III), in ewes during the breeding season. Experiments I and II indicated that the optimal EB treatment was 100 μg administered at 0 h. In Experiment III, pregnancy rates did not differ between eCG- and EB-based ES protocols. These findings suggest that EB can replace eCG in ES protocols with FTAI at 50–55 h using fresh semen, although further research is needed to refine the timing of FTAI.
publisher Universidad Nacional del Nordeste
publishDate 2025
url https://revistas.unne.edu.ar/index.php/vet/article/view/8740
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first_indexed 2025-10-17T05:01:09Z
last_indexed 2025-10-17T05:01:09Z
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