Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis
Parasite-host interaction is a complex relationship that determines the outcome of infection. Trichinella spiralis is a nematode that affects a wide range of animals and can transmit infection to humans. Studying its interaction with the host is essential for developing strategies to reduce the impa...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2025
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| Materias: | |
| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/8324 |
| Aporte de: |
| id |
I48-R154-article-8324 |
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ojs |
| institution |
Universidad Nacional del Nordeste |
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I-48 |
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R-154 |
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Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
Trichinella spiralis mice selection weight genetic variability susceptibility Trichinella spiralis ratones selección peso variabilidad genética susceptibilidad |
| spellingShingle |
Trichinella spiralis mice selection weight genetic variability susceptibility Trichinella spiralis ratones selección peso variabilidad genética susceptibilidad González Beltrán, S. Orozco, N. Coscelli, G. Villanueva, P. Oyarzabal, M. I. Giudici, C. Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| topic_facet |
Trichinella spiralis mice selection weight genetic variability susceptibility Trichinella spiralis ratones selección peso variabilidad genética susceptibilidad |
| author |
González Beltrán, S. Orozco, N. Coscelli, G. Villanueva, P. Oyarzabal, M. I. Giudici, C. |
| author_facet |
González Beltrán, S. Orozco, N. Coscelli, G. Villanueva, P. Oyarzabal, M. I. Giudici, C. |
| author_sort |
González Beltrán, S. |
| title |
Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| title_short |
Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| title_full |
Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| title_fullStr |
Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| title_full_unstemmed |
Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis |
| title_sort |
variability in parasite–host interactions among different mus musculus genotypes experimentally challenged with trichinella spiralis |
| description |
Parasite-host interaction is a complex relationship that determines the outcome of infection. Trichinella spiralis is a nematode that affects a wide range of animals and can transmit infection to humans. Studying its interaction with the host is essential for developing strategies to reduce the impact of this parasitosis. The aim of this study was to evaluate potential differences in parasite-host interaction in response to a Trichinella spiralis challenge among different host genotypes, consisting of four mouse lines selected by body weight and a control line derived from the CF1 strain (s, h, s’, h’, and t, respectively). Male mice from the lines were infected with a dose of 400 muscle larvae. The expulsion index at 15 days post-infection indicated that the t line was the most efficient, whereas the h line was the least efficient in this process, showing the highest number of adult worms in the intestine. In the chronic stage of infection, the number of encysted muscle larvae (relative parasitic load) was significantly higher in the light h line and lower in the t and h’ lines, indicating differences in the host-parasite interaction among the genotypes. Histopathological evaluation of the duodenum also revealed differences among the studied lines. The observed variability may result from the systematic process of phenotypic artificial selection for body weight, along with dispersive effects - such as the founder effect and genetic drift - associated with the low effective population size. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2025 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/8324 |
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I48-R154-article-83242025-08-02T00:14:37Z Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis Variabilidad de la interacción parásito-hospedador de diferentes genotipos Mus musculus al desafío experimental con Trichinella spiralis González Beltrán, S. Orozco, N. Coscelli, G. Villanueva, P. Oyarzabal, M. I. Giudici, C. Trichinella spiralis mice selection weight genetic variability susceptibility Trichinella spiralis ratones selección peso variabilidad genética susceptibilidad Parasite-host interaction is a complex relationship that determines the outcome of infection. Trichinella spiralis is a nematode that affects a wide range of animals and can transmit infection to humans. Studying its interaction with the host is essential for developing strategies to reduce the impact of this parasitosis. The aim of this study was to evaluate potential differences in parasite-host interaction in response to a Trichinella spiralis challenge among different host genotypes, consisting of four mouse lines selected by body weight and a control line derived from the CF1 strain (s, h, s’, h’, and t, respectively). Male mice from the lines were infected with a dose of 400 muscle larvae. The expulsion index at 15 days post-infection indicated that the t line was the most efficient, whereas the h line was the least efficient in this process, showing the highest number of adult worms in the intestine. In the chronic stage of infection, the number of encysted muscle larvae (relative parasitic load) was significantly higher in the light h line and lower in the t and h’ lines, indicating differences in the host-parasite interaction among the genotypes. Histopathological evaluation of the duodenum also revealed differences among the studied lines. The observed variability may result from the systematic process of phenotypic artificial selection for body weight, along with dispersive effects - such as the founder effect and genetic drift - associated with the low effective population size. La interacción parásito-hospedador es una relación compleja que determina el resultado de una infección. Trichinella spiralis es un nematodo que afecta a una amplia gama de animales, los que pueden transmitir la infección al humano. El estudio de la interacción con su hospedador es fundamental para obtener estrategias que permitan reducir esta parasitosis. El objetivo de esta investigación fue evaluar las potenciales diferencias en la interacción parásito-hospedador frente al desafío con Trichinella spiralis por parte de diferentes genotipos de hospedadores, conformados por cuatro líneas de ratones seleccionadas por peso y una línea testigo derivadas de la cepa CF1 (s, h, s´, h´ y t, respectivamente). Fueron infectados ratones macho de las líneas con una dosis de 400 larvas musculares. El índice de expulsión, a los 15 días posinfección, demostró que la línea t fue la más eficiente, mientras que la línea h fue la más ineficiente en este proceso, al presentar el mayor número de gusanos adultos en el intestino. En la etapa crónica de la infección, el número de larvas musculares enquistadas (carga parasitaria relativa) fue significativamente mayor en la línea liviana h, y menor en t y h´, mostrando diferencias en la interacción entre las líneas. La evaluación de los cambios histopatológicos del duodeno también mostró diferencias entre las líneas estudiadas. Esta variabilidad hallada sería producto del proceso sistemático de selección artificial fenotípica por peso corporal a los que se suman los efectos dispersivos -efecto fundador y deriva génica- asociados al bajo tamaño efectivo de las poblaciones. Universidad Nacional del Nordeste 2025-06-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/8324 10.30972/vet.3628324 Revista Veterinaria; Vol. 36 Núm. 2 (2025); 1-8 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/8324/7895 https://creativecommons.org/licenses/by-nc/4.0 |