Variability in parasite–host interactions among different Mus musculus genotypes experimentally challenged with Trichinella spiralis
Parasite-host interaction is a complex relationship that determines the outcome of infection. Trichinella spiralis is a nematode that affects a wide range of animals and can transmit infection to humans. Studying its interaction with the host is essential for developing strategies to reduce the impa...
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| Autores principales: | , , , , , |
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| Formato: | Artículo revista |
| Lenguaje: | Español |
| Publicado: |
Universidad Nacional del Nordeste
2025
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| Materias: | |
| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/8324 |
| Aporte de: |
| Sumario: | Parasite-host interaction is a complex relationship that determines the outcome of infection. Trichinella spiralis is a nematode that affects a wide range of animals and can transmit infection to humans. Studying its interaction with the host is essential for developing strategies to reduce the impact of this parasitosis. The aim of this study was to evaluate potential differences in parasite-host interaction in response to a Trichinella spiralis challenge among different host genotypes, consisting of four mouse lines selected by body weight and a control line derived from the CF1 strain (s, h, s’, h’, and t, respectively). Male mice from the lines were infected with a dose of 400 muscle larvae. The expulsion index at 15 days post-infection indicated that the t line was the most efficient, whereas the h line was the least efficient in this process, showing the highest number of adult worms in the intestine. In the chronic stage of infection, the number of encysted muscle larvae (relative parasitic load) was significantly higher in the light h line and lower in the t and h’ lines, indicating differences in the host-parasite interaction among the genotypes. Histopathological evaluation of the duodenum also revealed differences among the studied lines. The observed variability may result from the systematic process of phenotypic artificial selection for body weight, along with dispersive effects - such as the founder effect and genetic drift - associated with the low effective population size. |
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