Adjuvant treatment of canine distemper with natural apitoxin
Canine distemper (CD) is the most widespread and highly contagious viral disease in dogs worldwide, with a high mortality rate. No specific treatment exists, only supportive care with antibiotics aimed at preventing secondary bacterial infections. Vaccination is recommended for the control of CD. Co...
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| Formato: | Artículo revista |
| Lenguaje: | Español |
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Universidad Nacional del Nordeste
2025
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| Acceso en línea: | https://revistas.unne.edu.ar/index.php/vet/article/view/7985 |
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I48-R154-article-79852025-02-11T14:37:16Z Adjuvant treatment of canine distemper with natural apitoxin Tratamiento coadyuvante de distemper canino con apitoxina natural Molina-Molina, E. J. Molina-Cuasapaz, E. G. Lascano Armas, P. J. Mera-Viera, E. H. dog immunoglobulin G immunoglobulin M perro inmunoglobulina G inmunoglobulina M moquillo Canine distemper (CD) is the most widespread and highly contagious viral disease in dogs worldwide, with a high mortality rate. No specific treatment exists, only supportive care with antibiotics aimed at preventing secondary bacterial infections. Vaccination is recommended for the control of CD. Consequently, this study was conducted to evaluate the immunomodulatory effect of natural apitoxin through bee stings (Apis mellifera) as an adjuvant in the treatment of this disease. Following anamnesis, clinical examination, and physical assessment of suspected cases, a CD test and serological confirmation were performed. Apitoxin application was administered every 24 and 48 hours over three days, using a completely randomized experimental design with a 95% confidence level. Immunoglobulin G (IgG) and Immunoglobulin M (IgM) titers were determined by immunoturbidimetry. Variables such as age, sex, weight (small < 8 kg, large > 8 kg), distemper vaccination, and disease stage showed no influence on immunoglobulin levels. However, ANOVA analysis revealed a significant increase in IgG levels 21 days post-apitoxin application every 48 hours, suggesting this alternative as a potential adjuvant therapy to enhance the immune response in CD supportive treatment. El distemper canino (DC, moquillo canino) es la enfermedad vírica más difundida en el mundo, altamente contagiosa y letal de los caninos; no existe tratamiento, sólo tratamiento de soporte con antibióticos que van dirigidos a la prevención de infecciones bacterianas secundarias. Para el control de DC se recomienda la inmunización por vacuna. En consecuencia; esta investigación, se llevó a cabo con el objetivo de evaluar el efecto inmunomodulador de la apitoxina natural, mediante picadura de abejas (Apis mellifera) como coadyuvante al tratamiento de esta enfermedad. Una vez realizada la anamnesis, exploración clínica y física de los pacientes con sospecha de enfermedad, se utilizó el test para distemper y confirmación por serología. La aplicación de apitoxina, se realizó cada 24 y 48 horas por tres días, y la investigación se llevó bajo el método experimental completamente al azar, con un nivel de confianza de 95%. La titulación de Inmunoglobulina G (IgG) e Inmunoglobulina M (IgM) se determinó con el método de inmunoturbidimetría. Las variables como edad, sexo, peso (pequeños < 8 kg, grandes > 8 kg), vacuna antimoquillo y etapa de la enfermedad no tuvieron influencia en el nivel de las inmunoglobulinas; en cambio, en el análisis de ANOVA los resultados reflejaron un incremento significativo de IgG a los 21 días luego de la aplicación de apitoxina cada 48 horas, lo que nos lleva a sugerir esta alternativa como terapia coadyuvante para mejorar la respuesta inmune en el tratamiento de soporte para DC. Universidad Nacional del Nordeste 2025-01-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.unne.edu.ar/index.php/vet/article/view/7985 10.30972/vet.3617985 Revista Veterinaria; Vol. 36 Núm. 1 (2025); 1-7 1669-6840 1668-4834 spa https://revistas.unne.edu.ar/index.php/vet/article/view/7985/7485 Derechos de autor 2025 E. J. Molina-Molina, E. G. Molina-Cuasapaz, P. J. Lascano Armas, E. H. Mera-Viera https://creativecommons.org/licenses/by-nc/4.0 |
| institution |
Universidad Nacional del Nordeste |
| institution_str |
I-48 |
| repository_str |
R-154 |
| container_title_str |
Revistas UNNE - Universidad Nacional del Noroeste (UNNE) |
| language |
Español |
| format |
Artículo revista |
| topic |
dog immunoglobulin G immunoglobulin M perro inmunoglobulina G inmunoglobulina M moquillo |
| spellingShingle |
dog immunoglobulin G immunoglobulin M perro inmunoglobulina G inmunoglobulina M moquillo Molina-Molina, E. J. Molina-Cuasapaz, E. G. Lascano Armas, P. J. Mera-Viera, E. H. Adjuvant treatment of canine distemper with natural apitoxin |
| topic_facet |
dog immunoglobulin G immunoglobulin M perro inmunoglobulina G inmunoglobulina M moquillo |
| author |
Molina-Molina, E. J. Molina-Cuasapaz, E. G. Lascano Armas, P. J. Mera-Viera, E. H. |
| author_facet |
Molina-Molina, E. J. Molina-Cuasapaz, E. G. Lascano Armas, P. J. Mera-Viera, E. H. |
| author_sort |
Molina-Molina, E. J. |
| title |
Adjuvant treatment of canine distemper with natural apitoxin |
| title_short |
Adjuvant treatment of canine distemper with natural apitoxin |
| title_full |
Adjuvant treatment of canine distemper with natural apitoxin |
| title_fullStr |
Adjuvant treatment of canine distemper with natural apitoxin |
| title_full_unstemmed |
Adjuvant treatment of canine distemper with natural apitoxin |
| title_sort |
adjuvant treatment of canine distemper with natural apitoxin |
| description |
Canine distemper (CD) is the most widespread and highly contagious viral disease in dogs worldwide, with a high mortality rate. No specific treatment exists, only supportive care with antibiotics aimed at preventing secondary bacterial infections. Vaccination is recommended for the control of CD. Consequently, this study was conducted to evaluate the immunomodulatory effect of natural apitoxin through bee stings (Apis mellifera) as an adjuvant in the treatment of this disease. Following anamnesis, clinical examination, and physical assessment of suspected cases, a CD test and serological confirmation were performed. Apitoxin application was administered every 24 and 48 hours over three days, using a completely randomized experimental design with a 95% confidence level. Immunoglobulin G (IgG) and Immunoglobulin M (IgM) titers were determined by immunoturbidimetry. Variables such as age, sex, weight (small < 8 kg, large > 8 kg), distemper vaccination, and disease stage showed no influence on immunoglobulin levels. However, ANOVA analysis revealed a significant increase in IgG levels 21 days post-apitoxin application every 48 hours, suggesting this alternative as a potential adjuvant therapy to enhance the immune response in CD supportive treatment. |
| publisher |
Universidad Nacional del Nordeste |
| publishDate |
2025 |
| url |
https://revistas.unne.edu.ar/index.php/vet/article/view/7985 |
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