Mechanisms of adaptation in the intestinal parasite Giardia lamblia

Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites u...

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Autor principal: Luján, Hugo Daniel
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2011
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/5015/1/A_Lujan.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-5015
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spelling I38-R144-50152025-11-11T17:21:22Z http://pa.bibdigital.ucc.edu.ar/5015/ Mechanisms of adaptation in the intestinal parasite Giardia lamblia Luján, Hugo Daniel R Medicina (General) Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into infective cysts. Encystation entails the synthesis, processing, transport, secretion and extracellular assembly of cyst wall components. To survive within the intestine, Giardia undergoes antigenic variation, a process by which the parasite continuously switches its major surface molecules, allowing the parasite to evade the host's immune response and produce chronic and recurrent infections. The objective of the present chapter is to provide a better understanding of the molecular mechanisms involved in adaptation and differentiation in Giardia, with a particular focus on the process of encystation and antigenic variation of this interesting micro-organism. 2011-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/5015/1/A_Lujan.pdf Luján, Hugo Daniel ORCID: https://orcid.org/0000-0002-3797-8315 <https://orcid.org/0000-0002-3797-8315> (2011) Mechanisms of adaptation in the intestinal parasite Giardia lamblia. Essays in Biochemistry, 51 (1). pp. 177-191. ISSN 00711365 info:eu-repo/semantics/altIdentifier/doi/10.1042/BSE0510177
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Luján, Hugo Daniel
Mechanisms of adaptation in the intestinal parasite Giardia lamblia
topic_facet R Medicina (General)
description Giardia lamblia, a parasite of humans, is a major source of waterborne diarrhoeal disease. Giardia is also an excellent system to study basic biochemical processes because it is a single-celled eukaryote with a small genome and its entire life cycle can be replicated in vitro. Giardia trophozoites undergo fundamental changes to survive outside the intestine of their host by differentiating into infective cysts. Encystation entails the synthesis, processing, transport, secretion and extracellular assembly of cyst wall components. To survive within the intestine, Giardia undergoes antigenic variation, a process by which the parasite continuously switches its major surface molecules, allowing the parasite to evade the host's immune response and produce chronic and recurrent infections. The objective of the present chapter is to provide a better understanding of the molecular mechanisms involved in adaptation and differentiation in Giardia, with a particular focus on the process of encystation and antigenic variation of this interesting micro-organism.
format Artículo
PeerReviewed
author Luján, Hugo Daniel
author_facet Luján, Hugo Daniel
author_sort Luján, Hugo Daniel
title Mechanisms of adaptation in the intestinal parasite Giardia lamblia
title_short Mechanisms of adaptation in the intestinal parasite Giardia lamblia
title_full Mechanisms of adaptation in the intestinal parasite Giardia lamblia
title_fullStr Mechanisms of adaptation in the intestinal parasite Giardia lamblia
title_full_unstemmed Mechanisms of adaptation in the intestinal parasite Giardia lamblia
title_sort mechanisms of adaptation in the intestinal parasite giardia lamblia
publishDate 2011
url http://pa.bibdigital.ucc.edu.ar/5015/1/A_Lujan.pdf
work_keys_str_mv AT lujanhugodaniel mechanismsofadaptationintheintestinalparasitegiardialamblia
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