Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides

Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kagenecki...

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Autores principales: Chiari, María Eugenia, Joray, Mariana Belén, Ruiz, Gustavo Miguel, Palacios, Sara María, Carpinella, María Cecilia
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
QD Química
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4986/1/A_Chiari.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4986
record_format dspace
spelling I38-R144-49862025-11-05T13:48:15Z http://pa.bibdigital.ucc.edu.ar/4986/ Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides Chiari, María Eugenia Joray, Mariana Belén Ruiz, Gustavo Miguel Palacios, Sara María Carpinella, María Cecilia QD Química Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4986/1/A_Chiari.pdf Chiari, María Eugenia, Joray, Mariana Belén ORCID: https://orcid.org/0000-0001-9042-6926 <https://orcid.org/0000-0001-9042-6926>, Ruiz, Gustavo Miguel ORCID: https://orcid.org/0000-0002-0571-3224 <https://orcid.org/0000-0002-0571-3224>, Palacios, Sara María and Carpinella, María Cecilia ORCID: https://orcid.org/0000-0001-5553-1851 <https://orcid.org/0000-0001-5553-1851> (2010) Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides. Food Chemistry, 120 (1). pp. 10-14. ISSN 03088146 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.foodchem.2009.09.061
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QD Química
spellingShingle QD Química
Chiari, María Eugenia
Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara María
Carpinella, María Cecilia
Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
topic_facet QD Química
description Screening of 91 native plants from central Argentina was carried out with the aim of finding new sources of anti-tyrosinase compounds. Extracts obtained from Achyrocline satureioides, Artemisia verlotiorum, Cotoneaster glaucophylla, Dalea elegans, Flourensia campestris, Jodina rhombifolia, Kageneckia lanceolata, Lepechinia floribunda, Lepechinia meyenii, Lithrea molleoides, Porlieria microphylla, Pterocaulon alopecuroides, Ruprechtia apetala, Senna aphylla, Sida rhombifolia, Solanum argentinum, Tagetes minuta and Thalictrum decipiens exhibited more than 90% inhibition of tyrosinase monophenolase activity at 1000 μg ml-1. D. elegans, L. meyenii and L. molleoides were the most potent with IC50 values of 0.48, 10.43 and 3.77 μg ml-1, respectively. D. elegans, L. molleoides and T. decipiens also showed more than 90% inhibition of diphenolase activity at 1000 μg ml-1, with the first of these being the most effective (IC50 = 49.27 μg ml-1). (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol (1) was isolated from L. molleoides as an effective tyrosinase inhibitor with l-tyrosine or l-DOPA as substrates (IC50 = 0.49 and 14.94 μg ml-1, respectively). Compound 1 was 37 times more active in monophenolase inhibitory activity than kojic acid used as a reference. Effective extracts as well as (Z,Z)-5-(trideca-4,7-dienyl)-resorcinol could prove to be promising preservative agents for use in the food industry.
format Artículo
PeerReviewed
author Chiari, María Eugenia
Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara María
Carpinella, María Cecilia
author_facet Chiari, María Eugenia
Joray, Mariana Belén
Ruiz, Gustavo Miguel
Palacios, Sara María
Carpinella, María Cecilia
author_sort Chiari, María Eugenia
title Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
title_short Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
title_full Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
title_fullStr Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
title_full_unstemmed Tyrosinase inhibitory activity of native plants from central Argentina: isolation of an active principle from Lithrea molleoides
title_sort tyrosinase inhibitory activity of native plants from central argentina: isolation of an active principle from lithrea molleoides
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/4986/1/A_Chiari.pdf
work_keys_str_mv AT chiarimariaeugenia tyrosinaseinhibitoryactivityofnativeplantsfromcentralargentinaisolationofanactiveprinciplefromlithreamolleoides
AT joraymarianabelen tyrosinaseinhibitoryactivityofnativeplantsfromcentralargentinaisolationofanactiveprinciplefromlithreamolleoides
AT ruizgustavomiguel tyrosinaseinhibitoryactivityofnativeplantsfromcentralargentinaisolationofanactiveprinciplefromlithreamolleoides
AT palaciossaramaria tyrosinaseinhibitoryactivityofnativeplantsfromcentralargentinaisolationofanactiveprinciplefromlithreamolleoides
AT carpinellamariacecilia tyrosinaseinhibitoryactivityofnativeplantsfromcentralargentinaisolationofanactiveprinciplefromlithreamolleoides
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