Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity

Ochratoxin A (OTA) is a toxin produced by Aspergillus and Penicillum moulds. Since OTA has not yet been evaluated in plant systems, this paper focused on describing the controversial effect OTA in an Allium root test model, which has known sensitivity to genotoxins and could be useful in toxin scree...

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Autores principales: Lerda, Daniel Enrique, Biaggi Bistoni, M., Pelliccioni, Patricia Miriam, Litterio, Nicolás Javier
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4980/1/A_Lerda.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4980
record_format dspace
spelling I38-R144-49802025-11-03T18:00:10Z http://pa.bibdigital.ucc.edu.ar/4980/ Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity Lerda, Daniel Enrique Biaggi Bistoni, M. Pelliccioni, Patricia Miriam Litterio, Nicolás Javier R Medicina (General) Ochratoxin A (OTA) is a toxin produced by Aspergillus and Penicillum moulds. Since OTA has not yet been evaluated in plant systems, this paper focused on describing the controversial effect OTA in an Allium root test model, which has known sensitivity to genotoxins and could be useful in toxin screening. Analyses of root growth and the root meristematic zone in response to OTA treatment were undertaken. The results show OTA toxicity to root growth at a concentration of 10 ug·ml-1 associated with inhibition of proliferation activity. Cytological changes observed in the Allium chromosome aberrations assay, at a concentration of 5.0 ug·ml-1, showed that OTA was able to induce genotoxicity at the chromosome level. These results indicate that plants cells (Allium cepa) are very sensitive to the mycotoxin OTA, as observed at the highest concentration. Under these conditions, OTA produced toxicity and cytogenetic injury. Evidence in vitro and in vivo indicates that OTA can induce damage at the DNA level. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4980/1/A_Lerda.pdf Lerda, Daniel Enrique ORCID: https://orcid.org/0000-0002-1257-0954 <https://orcid.org/0000-0002-1257-0954>, Biaggi Bistoni, M., Pelliccioni, Patricia Miriam ORCID: https://orcid.org/0000-0003-3476-8336 <https://orcid.org/0000-0003-3476-8336> and Litterio, Nicolás Javier ORCID: https://orcid.org/0000-0002-8114-0579 <https://orcid.org/0000-0002-8114-0579> (2010) Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity. Plant Biology, 12 (4). pp. 685-688. ISSN 14388677 info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1438-8677.2010.00337.x
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Lerda, Daniel Enrique
Biaggi Bistoni, M.
Pelliccioni, Patricia Miriam
Litterio, Nicolás Javier
Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
topic_facet R Medicina (General)
description Ochratoxin A (OTA) is a toxin produced by Aspergillus and Penicillum moulds. Since OTA has not yet been evaluated in plant systems, this paper focused on describing the controversial effect OTA in an Allium root test model, which has known sensitivity to genotoxins and could be useful in toxin screening. Analyses of root growth and the root meristematic zone in response to OTA treatment were undertaken. The results show OTA toxicity to root growth at a concentration of 10 ug·ml-1 associated with inhibition of proliferation activity. Cytological changes observed in the Allium chromosome aberrations assay, at a concentration of 5.0 ug·ml-1, showed that OTA was able to induce genotoxicity at the chromosome level. These results indicate that plants cells (Allium cepa) are very sensitive to the mycotoxin OTA, as observed at the highest concentration. Under these conditions, OTA produced toxicity and cytogenetic injury. Evidence in vitro and in vivo indicates that OTA can induce damage at the DNA level.
format Artículo
PeerReviewed
author Lerda, Daniel Enrique
Biaggi Bistoni, M.
Pelliccioni, Patricia Miriam
Litterio, Nicolás Javier
author_facet Lerda, Daniel Enrique
Biaggi Bistoni, M.
Pelliccioni, Patricia Miriam
Litterio, Nicolás Javier
author_sort Lerda, Daniel Enrique
title Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
title_short Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
title_full Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
title_fullStr Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
title_full_unstemmed Allium cepa as a biomonitor of ochratoxin A toxicity and genotoxicity
title_sort allium cepa as a biomonitor of ochratoxin a toxicity and genotoxicity
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/4980/1/A_Lerda.pdf
work_keys_str_mv AT lerdadanielenrique alliumcepaasabiomonitorofochratoxinatoxicityandgenotoxicity
AT biaggibistonim alliumcepaasabiomonitorofochratoxinatoxicityandgenotoxicity
AT pelliccionipatriciamiriam alliumcepaasabiomonitorofochratoxinatoxicityandgenotoxicity
AT litterionicolasjavier alliumcepaasabiomonitorofochratoxinatoxicityandgenotoxicity
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