Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina

In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although in most people this process is not complete. Previous studies have identified associations between the proportion of urinary MMA (%MMA) and increased risks of several arsenic-relat...

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Autores principales: Steinmaus, Craig, Yuan, Yan, Kalman, Dave, Rey, Omar A., Skibola, Christine F., Dauphine, Dave, Basu, Anamika, Porter, Kristin E., Hubbard, Alan, Bates, Michael N., Smith, Martyn T., Smith, Allan H.
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: Academic Press Inc. 2010
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4975/1/A_Steinmaus.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4975
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spelling I38-R144-49752025-11-03T14:13:23Z http://pa.bibdigital.ucc.edu.ar/4975/ Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina Steinmaus, Craig Yuan, Yan Kalman, Dave Rey, Omar A. Skibola, Christine F. Dauphine, Dave Basu, Anamika Porter, Kristin E. Hubbard, Alan Bates, Michael N. Smith, Martyn T. Smith, Allan H. R Medicina (General) In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although in most people this process is not complete. Previous studies have identified associations between the proportion of urinary MMA (%MMA) and increased risks of several arsenic-related diseases, although none of these reported on lung cancer. In this study, urinary arsenic metabolites were assessed in 45 lung cancer cases and 75 controls from arsenic-exposed areas in Cordoba, Argentina. Folate has also been linked to arsenic-disease susceptibility, thus an exploratory assessment of associations between single nucleotide polymorphisms in folate metabolizing genes, arsenic methylation, and lung cancer was also conducted. In analyses limited to subjects with metabolite concentrations above detection limits, the mean %MMA was higher in cases than in controls (17.5% versus 14.3%, p=0.01). The lung cancer odds ratio for subjects with %MMA in the upper tertile compared to those in the lowest tertile was 3.09 (95% CI, 1.08-8.81). Although the study size was too small for a definitive conclusion, there was an indication that lung cancer risks might be highest in those with a high %MMA who also carried cystathionine β-synthase (CBS) rs234709 and rs4920037 variant alleles. This study is the first to report an association between individual differences in arsenic metabolism and lung cancer, a leading cause of arsenic-related mortality. These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility. Academic Press Inc. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4975/1/A_Steinmaus.pdf Steinmaus, Craig ORCID: https://orcid.org/0000-0003-2697-843X <https://orcid.org/0000-0003-2697-843X>, Yuan, Yan, Kalman, Dave, Rey, Omar A., Skibola, Christine F., Dauphine, Dave, Basu, Anamika, Porter, Kristin E., Hubbard, Alan, Bates, Michael N., Smith, Martyn T. and Smith, Allan H. (2010) Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina. Toxicology and Applied Pharmacology, 247 (2). pp. 138-145. ISSN 20600216 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.taap.2010.06.006 Copy to clipboard
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Steinmaus, Craig
Yuan, Yan
Kalman, Dave
Rey, Omar A.
Skibola, Christine F.
Dauphine, Dave
Basu, Anamika
Porter, Kristin E.
Hubbard, Alan
Bates, Michael N.
Smith, Martyn T.
Smith, Allan H.
Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
topic_facet R Medicina (General)
description In humans, ingested inorganic arsenic is metabolized to monomethylarsenic (MMA) then to dimethylarsenic (DMA), although in most people this process is not complete. Previous studies have identified associations between the proportion of urinary MMA (%MMA) and increased risks of several arsenic-related diseases, although none of these reported on lung cancer. In this study, urinary arsenic metabolites were assessed in 45 lung cancer cases and 75 controls from arsenic-exposed areas in Cordoba, Argentina. Folate has also been linked to arsenic-disease susceptibility, thus an exploratory assessment of associations between single nucleotide polymorphisms in folate metabolizing genes, arsenic methylation, and lung cancer was also conducted. In analyses limited to subjects with metabolite concentrations above detection limits, the mean %MMA was higher in cases than in controls (17.5% versus 14.3%, p=0.01). The lung cancer odds ratio for subjects with %MMA in the upper tertile compared to those in the lowest tertile was 3.09 (95% CI, 1.08-8.81). Although the study size was too small for a definitive conclusion, there was an indication that lung cancer risks might be highest in those with a high %MMA who also carried cystathionine β-synthase (CBS) rs234709 and rs4920037 variant alleles. This study is the first to report an association between individual differences in arsenic metabolism and lung cancer, a leading cause of arsenic-related mortality. These results add to the increasing body of evidence that variation in arsenic metabolism plays an important role in arsenic-disease susceptibility.
format Artículo
PeerReviewed
author Steinmaus, Craig
Yuan, Yan
Kalman, Dave
Rey, Omar A.
Skibola, Christine F.
Dauphine, Dave
Basu, Anamika
Porter, Kristin E.
Hubbard, Alan
Bates, Michael N.
Smith, Martyn T.
Smith, Allan H.
author_facet Steinmaus, Craig
Yuan, Yan
Kalman, Dave
Rey, Omar A.
Skibola, Christine F.
Dauphine, Dave
Basu, Anamika
Porter, Kristin E.
Hubbard, Alan
Bates, Michael N.
Smith, Martyn T.
Smith, Allan H.
author_sort Steinmaus, Craig
title Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
title_short Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
title_full Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
title_fullStr Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
title_full_unstemmed Individual differences in arsenic metabolism and lung cancer in a case-control study in Cordoba, Argentina
title_sort individual differences in arsenic metabolism and lung cancer in a case-control study in cordoba, argentina
publisher Academic Press Inc.
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/4975/1/A_Steinmaus.pdf
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