A simple allele-specific polymerase chain reaction method to detect the Gly143Glu polymorphism in the human carboxylesterase 1 gene: importance of genotyping for pharmacogenetic treatment

Human carboxylesterases 1 and 2 (CES1 and CES2) catalyze the hydrolysis of many exogenous compounds. Alterations in CES sequences could lead to variability in both the inactivation of drugs and the activation of prodrugs. The human CES1 gene encodes for the enzyme carboxylesterase 1, a serine estera...

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Autores principales: Soria, Néstor Walter, Belaus, Andrea, Galván, Cristian Ariel, Pasquali, María Ana, Vélez, Pablo, Montes, Cecilia del Carmen, Beltramo, Dante Miguel
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
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Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4965/1/A_Soria.pdf
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