Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]

Trypanosoma cruzi, ethiologic agent of Chagas disease, affects about 2.500.000 people in our country and 18 millon in Latin America. The parasite presents two stages of medical importance in the host, the amastigote, intracellular replicating form and the extracellular trypomastigote, the infective...

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Autores principales: Marini, Vanina Natalia, Basso, Beatriz
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2010
Materias:
QD Química
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4964/1/A_Marini.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4964
record_format dspace
spelling I38-R144-49642025-10-30T12:34:26Z http://pa.bibdigital.ucc.edu.ar/4964/ Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental] Marini, Vanina Natalia Basso, Beatriz QD Química Trypanosoma cruzi, ethiologic agent of Chagas disease, affects about 2.500.000 people in our country and 18 millon in Latin America. The parasite presents two stages of medical importance in the host, the amastigote, intracellular replicating form and the extracellular trypomastigote, the infective form. That is why the control of infection requires a strong humoral and cellular immune response, hence, it is very important the outcome of host-parasite interaction in the early stages of infection. 30% of infected people, develop some degree of pathology, cardiac or digestive in the chronic period of infection, attribute this to the direct action of the parasite, or to autoimmune reactions induced by Trypanosoma cruzi. The aim of this work was to study at local level, in a murine experimental model some mediators in the early infections with T. cruzi and the adaptive response at the end of the acute phase. The results revealed increased respiratory burst and synthesis of IL-6 since the first hours. Nitric oxide concentration increased with the progression of the infection, while the activation of arginase remained regulated and it was important the specific immunoglobulin production. These mediators would be involved in mechanisms of resistence to T. cruzi, but also in the pathogenia of the infection. These findings stimulate to go further in the knowledge of immunological early events directed to the development to therapeutic approaches in Chagas disease. 2010-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4964/1/A_Marini.pdf Marini, Vanina Natalia ORCID: https://orcid.org/0000-0002-3969-632X <https://orcid.org/0000-0002-3969-632X> and Basso, Beatriz (2010) Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]. Archivos de Alergia e Inmunologia Clinica, 41 (2). pp. 61-67. ISSN 15159825
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic QD Química
spellingShingle QD Química
Marini, Vanina Natalia
Basso, Beatriz
Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
topic_facet QD Química
description Trypanosoma cruzi, ethiologic agent of Chagas disease, affects about 2.500.000 people in our country and 18 millon in Latin America. The parasite presents two stages of medical importance in the host, the amastigote, intracellular replicating form and the extracellular trypomastigote, the infective form. That is why the control of infection requires a strong humoral and cellular immune response, hence, it is very important the outcome of host-parasite interaction in the early stages of infection. 30% of infected people, develop some degree of pathology, cardiac or digestive in the chronic period of infection, attribute this to the direct action of the parasite, or to autoimmune reactions induced by Trypanosoma cruzi. The aim of this work was to study at local level, in a murine experimental model some mediators in the early infections with T. cruzi and the adaptive response at the end of the acute phase. The results revealed increased respiratory burst and synthesis of IL-6 since the first hours. Nitric oxide concentration increased with the progression of the infection, while the activation of arginase remained regulated and it was important the specific immunoglobulin production. These mediators would be involved in mechanisms of resistence to T. cruzi, but also in the pathogenia of the infection. These findings stimulate to go further in the knowledge of immunological early events directed to the development to therapeutic approaches in Chagas disease.
format Artículo
PeerReviewed
author Marini, Vanina Natalia
Basso, Beatriz
author_facet Marini, Vanina Natalia
Basso, Beatriz
author_sort Marini, Vanina Natalia
title Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
title_short Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
title_full Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
title_fullStr Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
title_full_unstemmed Soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [Mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
title_sort soluble mediators in trypanosoma cruzi infection could trigger mechanisms of pathogenesis in chagas disease [mediadores solubles liberados por la infección con trypanosoma cruzi podrían desencadenar mecanismos de fisiopatogenia en la enfermedad de chagas experimental]
publishDate 2010
url http://pa.bibdigital.ucc.edu.ar/4964/1/A_Marini.pdf
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