Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia

Giardia lamblia trophozoites lack organelles typical of higher eukaryotes such asmitochondria, peroxisomes and compartments involved in intracellular protein traffickingand secretion, the Golgi apparatus and secretory granules. Nevertheless, the minimalmachinery for protein transport and sorting is...

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Autores principales: Elías, Eliana Vanina, Gottig, Natalia, Quiroga, Rodrigo, Luján, Hugo Daniel
Formato: Artículo PeerReviewed
Lenguaje:Español
Publicado: 2009
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4948/1/A_Elias.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4948
record_format dspace
spelling I38-R144-49482025-10-24T13:07:42Z http://pa.bibdigital.ucc.edu.ar/4948/ Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia Elías, Eliana Vanina Gottig, Natalia Quiroga, Rodrigo Luján, Hugo Daniel R Medicina (General) Giardia lamblia trophozoites lack organelles typical of higher eukaryotes such asmitochondria, peroxisomes and compartments involved in intracellular protein traffickingand secretion, the Golgi apparatus and secretory granules. Nevertheless, the minimalmachinery for protein transport and sorting is present in this parasite. When Giardiaundergoes encystation, the biogenesis of secretory organelles necessary to transport cystwall constituents to the cell surface takes place. Although both constitutive and regulatedpathways for protein secretion exist in Giardia, little is known about the molecules andmechanisms specifically involved in vesicular docking and fusion. In higher eukaryotes,soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) of thevesicle-associated membrane protein (VAMP) and syntaxin proteins play an essential rolein these processes through the formation of complexes between proteins present on donorand target membranes. Recent studies in both vegetative and encysting trophozoiteshave provided interesting information regarding the secretory pathway of this importantpathogen. 2009-12-31 Artículo PeerReviewed application/pdf spa http://pa.bibdigital.ucc.edu.ar/4948/1/A_Elias.pdf Elías, Eliana Vanina ORCID: https://orcid.org/0000-0003-2516-9219 <https://orcid.org/0000-0003-2516-9219>, Gottig, Natalia ORCID: https://orcid.org/0000-0002-8730-8248 <https://orcid.org/0000-0002-8730-8248>, Quiroga, Rodrigo ORCID: https://orcid.org/0000-0001-5015-0531 <https://orcid.org/0000-0001-5015-0531> and Luján, Hugo Daniel ORCID: https://orcid.org/0000-0002-3797-8315 <https://orcid.org/0000-0002-3797-8315> (2009) Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia. Giardia and Cryptosporidium: From Molecules to Diseases. ISSN 9781845933913
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Elías, Eliana Vanina
Gottig, Natalia
Quiroga, Rodrigo
Luján, Hugo Daniel
Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
topic_facet R Medicina (General)
description Giardia lamblia trophozoites lack organelles typical of higher eukaryotes such asmitochondria, peroxisomes and compartments involved in intracellular protein traffickingand secretion, the Golgi apparatus and secretory granules. Nevertheless, the minimalmachinery for protein transport and sorting is present in this parasite. When Giardiaundergoes encystation, the biogenesis of secretory organelles necessary to transport cystwall constituents to the cell surface takes place. Although both constitutive and regulatedpathways for protein secretion exist in Giardia, little is known about the molecules andmechanisms specifically involved in vesicular docking and fusion. In higher eukaryotes,soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) of thevesicle-associated membrane protein (VAMP) and syntaxin proteins play an essential rolein these processes through the formation of complexes between proteins present on donorand target membranes. Recent studies in both vegetative and encysting trophozoiteshave provided interesting information regarding the secretory pathway of this importantpathogen.
format Artículo
PeerReviewed
author Elías, Eliana Vanina
Gottig, Natalia
Quiroga, Rodrigo
Luján, Hugo Daniel
author_facet Elías, Eliana Vanina
Gottig, Natalia
Quiroga, Rodrigo
Luján, Hugo Daniel
author_sort Elías, Eliana Vanina
title Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
title_short Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
title_full Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
title_fullStr Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
title_full_unstemmed Secretory granule biogenesisand the organization of membrane compartments via SNARE proteins in Giardia lamblia
title_sort secretory granule biogenesisand the organization of membrane compartments via snare proteins in giardia lamblia
publishDate 2009
url http://pa.bibdigital.ucc.edu.ar/4948/1/A_Elias.pdf
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AT quirogarodrigo secretorygranulebiogenesisandtheorganizationofmembranecompartmentsviasnareproteinsingiardialamblia
AT lujanhugodaniel secretorygranulebiogenesisandtheorganizationofmembranecompartmentsviasnareproteinsingiardialamblia
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