Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]

Progressive Multifocal Leucoencephalopaty (PML) is an untreatable viral infection of the brain white matter, seen in persons with very advanced HIV infection. We report a 28 year-old homosexual man assisted in Córdoba City (Argentina). He started suddenly with fever, seizures and altered mental stat...

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Autores principales: Chalub, Elías Pedro, Theaux, Ricardo, Villegas, Elda María
Formato: Artículo
Lenguaje:Español
Publicado: 2008
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4821/1/A_Chalub.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4821
record_format dspace
spelling I38-R144-48212025-09-16T13:26:09Z http://pa.bibdigital.ucc.edu.ar/4821/ Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso] Chalub, Elías Pedro Theaux, Ricardo Villegas, Elda María R Medicina (General) Progressive Multifocal Leucoencephalopaty (PML) is an untreatable viral infection of the brain white matter, seen in persons with very advanced HIV infection. We report a 28 year-old homosexual man assisted in Córdoba City (Argentina). He started suddenly with fever, seizures and altered mental status. Then he had focal neurologic defects such as: aphasia and left hemiparesis. Patient also had thrush and skin lesions which resembled Kaposi' sarcoma. Computed Tomography scanning (CT) didn't show important findings, but Magnetic Resonance Imaging (MRI) detected nonenhancing white matter lesions without mass effect on the right side of basal ganglia, suggestive of PML. Cerebral spinal fluid (CSF) findings were normal. HIV tests (ELISA/Western-blot) , were positive and CD4 cell-count was 70/mm3. Stereotactic cerebral biopsy was performed without complications, anatomo-pathological examination and PCR test for the detection of JV Virus, confirmed the diagnosis of PML. KS was also diagnosed by skin biopsy. No treatment has been demonstrated effective for PML so, our patient received HAART (Zidovudine/Lamivudine/ Lopinavir-ritonavir). He gradually experienced progressive improvement during follow-up. Seven years later, his clinical, radiological and virological aspects, have been stabilized. We point out that JC virus may generally affect untreated AIDS-patients. PML doesn't have specific neurologic symptoms, MRI may be typical, but cerebral biopsy, made in some cases, certifies the diagnosis. Finally, we agree with other authors that PML in AIDS-patients may improve with HAART. 2008-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4821/1/A_Chalub.pdf Chalub, Elías Pedro, Theaux, Ricardo and Villegas, Elda María (2008) Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]. Prensa Medica Argentina, 95 (1). pp. 44-48. ISSN 0032745X
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Chalub, Elías Pedro
Theaux, Ricardo
Villegas, Elda María
Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
topic_facet R Medicina (General)
description Progressive Multifocal Leucoencephalopaty (PML) is an untreatable viral infection of the brain white matter, seen in persons with very advanced HIV infection. We report a 28 year-old homosexual man assisted in Córdoba City (Argentina). He started suddenly with fever, seizures and altered mental status. Then he had focal neurologic defects such as: aphasia and left hemiparesis. Patient also had thrush and skin lesions which resembled Kaposi' sarcoma. Computed Tomography scanning (CT) didn't show important findings, but Magnetic Resonance Imaging (MRI) detected nonenhancing white matter lesions without mass effect on the right side of basal ganglia, suggestive of PML. Cerebral spinal fluid (CSF) findings were normal. HIV tests (ELISA/Western-blot) , were positive and CD4 cell-count was 70/mm3. Stereotactic cerebral biopsy was performed without complications, anatomo-pathological examination and PCR test for the detection of JV Virus, confirmed the diagnosis of PML. KS was also diagnosed by skin biopsy. No treatment has been demonstrated effective for PML so, our patient received HAART (Zidovudine/Lamivudine/ Lopinavir-ritonavir). He gradually experienced progressive improvement during follow-up. Seven years later, his clinical, radiological and virological aspects, have been stabilized. We point out that JC virus may generally affect untreated AIDS-patients. PML doesn't have specific neurologic symptoms, MRI may be typical, but cerebral biopsy, made in some cases, certifies the diagnosis. Finally, we agree with other authors that PML in AIDS-patients may improve with HAART.
format Artículo
author Chalub, Elías Pedro
Theaux, Ricardo
Villegas, Elda María
author_facet Chalub, Elías Pedro
Theaux, Ricardo
Villegas, Elda María
author_sort Chalub, Elías Pedro
title Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
title_short Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
title_full Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
title_fullStr Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
title_full_unstemmed Progressive multifocal leucoencephalopaty in a patient with aids [Leucoencefalopatía multifocal progresiva en paciente con SIDA. Presentación de un caso]
title_sort progressive multifocal leucoencephalopaty in a patient with aids [leucoencefalopatía multifocal progresiva en paciente con sida. presentación de un caso]
publishDate 2008
url http://pa.bibdigital.ucc.edu.ar/4821/1/A_Chalub.pdf
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AT villegaseldamaria progressivemultifocalleucoencephalopatyinapatientwithaidsleucoencefalopatiamultifocalprogresivaenpacienteconsidapresentaciondeuncaso
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