Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration

The aim of this work was to study the pharmacokinetic behaviour and the inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities of chlorpyrifos in male and female cattle after pour-on administration. Determination of cholinesterase activity in plasma and erythrocyte was carrie...

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Autores principales: Picco, Eduardo J., Rubio, Marcelo R., Díaz David, Diego C., Rodriguez Fenández, Casilda, Boggio, Juan Carlos
Formato: Artículo
Lenguaje:Español
Publicado: 2008
Materias:
SF Cultura de los animales
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4816/1/A_Picco.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4816
record_format dspace
spelling I38-R144-48162025-05-07T18:16:35Z http://pa.bibdigital.ucc.edu.ar/4816/ Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration Picco, Eduardo J. Rubio, Marcelo R. Díaz David, Diego C. Rodriguez Fenández, Casilda Boggio, Juan Carlos SF Cultura de los animales The aim of this work was to study the pharmacokinetic behaviour and the inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities of chlorpyrifos in male and female cattle after pour-on administration. Determination of cholinesterase activity in plasma and erythrocyte was carried out according to Ellman kinetic method. The mean baseline activities were 9338.39±1331.61 and 13220.69±2274.18 to acetylcholinesterase and 624.65±39.32 and 641.68±88.08 IU/L to butyrylcholinesterase in females and males, respectively. Acetylcholinesterase was the predominant form of cholinesterase analyzed, with low levels of butyrylcholinesterase. The basal acetylcholinesterase activities of the bulls were significantly greater than those of cows. The inhibitory effect of topical chlorpyrifos administration was lower on butyrylcholinesterase than on acetylcholinesterase. Chlorpyrifos peak plasma concentration (male:10.920±4.18; female:12.12±3.88 μg/L) were reached at 11.92±9.19 and 8.17±7.67 h in male and female, respectively. The values of area under curve were 185.96±168.45 and 278.89±270.00 μg/L and mean residence time were 13.95±8.10 and 14.90±9.80 h in male and female, respectively. 2008-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4816/1/A_Picco.pdf Picco, Eduardo J., Rubio, Marcelo R., Díaz David, Diego C., Rodriguez Fenández, Casilda and Boggio, Juan Carlos ORCID: https://orcid.org/0000-0001-9748-001X <https://orcid.org/0000-0001-9748-001X> (2008) Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration. Veterinary Research Communications, 33 (5). pp. 401-410. ISSN 01657380 info:eu-repo/semantics/altIdentifier/doi/10.1007/s11259-008-9035-0
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic SF Cultura de los animales
spellingShingle SF Cultura de los animales
Picco, Eduardo J.
Rubio, Marcelo R.
Díaz David, Diego C.
Rodriguez Fenández, Casilda
Boggio, Juan Carlos
Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
topic_facet SF Cultura de los animales
description The aim of this work was to study the pharmacokinetic behaviour and the inhibitory effect on acetylcholinesterase and butyrylcholinesterase activities of chlorpyrifos in male and female cattle after pour-on administration. Determination of cholinesterase activity in plasma and erythrocyte was carried out according to Ellman kinetic method. The mean baseline activities were 9338.39±1331.61 and 13220.69±2274.18 to acetylcholinesterase and 624.65±39.32 and 641.68±88.08 IU/L to butyrylcholinesterase in females and males, respectively. Acetylcholinesterase was the predominant form of cholinesterase analyzed, with low levels of butyrylcholinesterase. The basal acetylcholinesterase activities of the bulls were significantly greater than those of cows. The inhibitory effect of topical chlorpyrifos administration was lower on butyrylcholinesterase than on acetylcholinesterase. Chlorpyrifos peak plasma concentration (male:10.920±4.18; female:12.12±3.88 μg/L) were reached at 11.92±9.19 and 8.17±7.67 h in male and female, respectively. The values of area under curve were 185.96±168.45 and 278.89±270.00 μg/L and mean residence time were 13.95±8.10 and 14.90±9.80 h in male and female, respectively.
format Artículo
author Picco, Eduardo J.
Rubio, Marcelo R.
Díaz David, Diego C.
Rodriguez Fenández, Casilda
Boggio, Juan Carlos
author_facet Picco, Eduardo J.
Rubio, Marcelo R.
Díaz David, Diego C.
Rodriguez Fenández, Casilda
Boggio, Juan Carlos
author_sort Picco, Eduardo J.
title Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
title_short Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
title_full Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
title_fullStr Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
title_full_unstemmed Pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
title_sort pharmacokinetics and pharmacodynamics of chlorpyrifos in male and female cattle after topical administration
publishDate 2008
url http://pa.bibdigital.ucc.edu.ar/4816/1/A_Picco.pdf
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AT rodriguezfenandezcasilda pharmacokineticsandpharmacodynamicsofchlorpyrifosinmaleandfemalecattleaftertopicaladministration
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