Solid-state characterization of two polymorphic forms of R-albuterol sulfate
R-Albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray p...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | Español |
| Publicado: |
Elseiver
2007
|
| Materias: | |
| Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/4033/1/A_Palacios_Cuffini_Badini_Karlsson_Palacios.pdf |
| Aporte de: |
| Sumario: | R-Albuterol (levalbuterol) is a drug used for asthma therapy and some formulations of it are in solid dosage forms. The aim of this work was to describe and characterize two polymorphic modifications of R-albuterol sulfate by means of typical structure-sensitive analytical techniques such as X-ray powder diffraction, FT-IR spectroscopy, visual and microscopic inspection, and DSC. Substantial differences were observed between the solid-state properties of the crystals, confirming the existence of at least two polymorphic forms for R-albuterol sulfate: Form I and Form II. |
|---|