New perspectives in the treatment of allergic rhinitis and asthma in children

PURPOSE OF REVIEW: Allergic rhinitis and asthma are some of the most prevalent chronic diseases in children. Meticulous evaluations of the therapeutic options and interventions are needed to control this burden. The central pathogenic mechanism is an immediate hypersensitivity reaction, followed by...

Descripción completa

Detalles Bibliográficos
Autores principales: Baena Cagnani, Carlos E., Passalacqua, Giovanni, Gómez, Maximiliano, Zernotti, Mario Emilio, Canonica, Giorgio Walter
Formato: Artículo
Lenguaje:Español
Publicado: Wolters Kluwer Health 2007
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4032/1/A_BaenaCagnani_Passalacqua_G%C3%B3mez_Zernotti_Canonica.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4032
record_format dspace
spelling I38-R144-40322025-04-07T20:09:06Z http://pa.bibdigital.ucc.edu.ar/4032/ New perspectives in the treatment of allergic rhinitis and asthma in children Baena Cagnani, Carlos E. Passalacqua, Giovanni Gómez, Maximiliano Zernotti, Mario Emilio Canonica, Giorgio Walter R Medicina (General) PURPOSE OF REVIEW: Allergic rhinitis and asthma are some of the most prevalent chronic diseases in children. Meticulous evaluations of the therapeutic options and interventions are needed to control this burden. The central pathogenic mechanism is an immediate hypersensitivity reaction, followed by interventions in the allergic cascade. Once inflammation is established, potent anti-inflammatory agents or mediator antagonists could help control the phenomenon and reduce the characteristic symptoms related to severity. RECENT FINDINGS: Monoclonal antibody against IgE has demonstrated its efficacy in reducing the symptoms of asthma and rhinitis. In difficult-to-treat asthma patients it allows a reduction in the dose of inhaled steroids, the number of exacerbations, emergency visits and hospitalizations. Its broad implementation is limited by its high cost because adverse events are not a concern. Specific sublingual immunotherapy gave promising results in clinical trials, while modifying immunoglobulins and cytokine profiles, also inducing T-cell tolerance. Safety issues of subcutaneous immunotherapy have been surpassed by the sublingual route, with equivalent efficacy. The new inhaled steroid ciclesonide is effective in established inflammation, is activated only in the respiratory system, and has negligible systemic effects. SUMMARY: Robust evidence on the efficacy and safety of several novel therapies in rhinitis and asthma is available. Wolters Kluwer Health 2007-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4032/1/A_BaenaCagnani_Passalacqua_G%C3%B3mez_Zernotti_Canonica.pdf Baena Cagnani, Carlos E., Passalacqua, Giovanni, Gómez, Maximiliano, Zernotti, Mario Emilio ORCID: https://orcid.org/0000-0003-4288-2809 <https://orcid.org/0000-0003-4288-2809> and Canonica, Giorgio Walter ORCID: https://orcid.org/0000-0001-8467-2557 <https://orcid.org/0000-0001-8467-2557> (2007) New perspectives in the treatment of allergic rhinitis and asthma in children. Current Opinion in Allergy and Clinical Immunology, 7 (2). pp. 201-206. ISSN 1473-6322 info:eu-repo/semantics/altIdentifier/doi/10.1097/ACI.0b013e3280895d36
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Baena Cagnani, Carlos E.
Passalacqua, Giovanni
Gómez, Maximiliano
Zernotti, Mario Emilio
Canonica, Giorgio Walter
New perspectives in the treatment of allergic rhinitis and asthma in children
topic_facet R Medicina (General)
description PURPOSE OF REVIEW: Allergic rhinitis and asthma are some of the most prevalent chronic diseases in children. Meticulous evaluations of the therapeutic options and interventions are needed to control this burden. The central pathogenic mechanism is an immediate hypersensitivity reaction, followed by interventions in the allergic cascade. Once inflammation is established, potent anti-inflammatory agents or mediator antagonists could help control the phenomenon and reduce the characteristic symptoms related to severity. RECENT FINDINGS: Monoclonal antibody against IgE has demonstrated its efficacy in reducing the symptoms of asthma and rhinitis. In difficult-to-treat asthma patients it allows a reduction in the dose of inhaled steroids, the number of exacerbations, emergency visits and hospitalizations. Its broad implementation is limited by its high cost because adverse events are not a concern. Specific sublingual immunotherapy gave promising results in clinical trials, while modifying immunoglobulins and cytokine profiles, also inducing T-cell tolerance. Safety issues of subcutaneous immunotherapy have been surpassed by the sublingual route, with equivalent efficacy. The new inhaled steroid ciclesonide is effective in established inflammation, is activated only in the respiratory system, and has negligible systemic effects. SUMMARY: Robust evidence on the efficacy and safety of several novel therapies in rhinitis and asthma is available.
format Artículo
author Baena Cagnani, Carlos E.
Passalacqua, Giovanni
Gómez, Maximiliano
Zernotti, Mario Emilio
Canonica, Giorgio Walter
author_facet Baena Cagnani, Carlos E.
Passalacqua, Giovanni
Gómez, Maximiliano
Zernotti, Mario Emilio
Canonica, Giorgio Walter
author_sort Baena Cagnani, Carlos E.
title New perspectives in the treatment of allergic rhinitis and asthma in children
title_short New perspectives in the treatment of allergic rhinitis and asthma in children
title_full New perspectives in the treatment of allergic rhinitis and asthma in children
title_fullStr New perspectives in the treatment of allergic rhinitis and asthma in children
title_full_unstemmed New perspectives in the treatment of allergic rhinitis and asthma in children
title_sort new perspectives in the treatment of allergic rhinitis and asthma in children
publisher Wolters Kluwer Health
publishDate 2007
url http://pa.bibdigital.ucc.edu.ar/4032/1/A_BaenaCagnani_Passalacqua_G%C3%B3mez_Zernotti_Canonica.pdf
work_keys_str_mv AT baenacagnanicarlose newperspectivesinthetreatmentofallergicrhinitisandasthmainchildren
AT passalacquagiovanni newperspectivesinthetreatmentofallergicrhinitisandasthmainchildren
AT gomezmaximiliano newperspectivesinthetreatmentofallergicrhinitisandasthmainchildren
AT zernottimarioemilio newperspectivesinthetreatmentofallergicrhinitisandasthmainchildren
AT canonicagiorgiowalter newperspectivesinthetreatmentofallergicrhinitisandasthmainchildren
_version_ 1832592434174885888

Ejemplares similares