Airway remodelling in children: when does it start?

The review characterizes airway remodelling in childhood asthma and describes how early in life it is possible to detect, and possibly cure, the cellular and biochemical changes that characterize this event. This topic is timely and relevant since a variety of clinical and epidemiologic studies stro...

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Autores principales: Baena Cagnani, Carlos E., Rossi, Giovanni A., Canonica, Giorgio Walter
Formato: Artículo
Lenguaje:Español
Publicado: Wolters Kluwer Health 2007
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4031/1/A_BaenaCagnani_Rossi_Canonica.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4031
record_format dspace
spelling I38-R144-40312025-04-07T20:07:27Z http://pa.bibdigital.ucc.edu.ar/4031/ Airway remodelling in children: when does it start? Baena Cagnani, Carlos E. Rossi, Giovanni A. Canonica, Giorgio Walter R Medicina (General) The review characterizes airway remodelling in childhood asthma and describes how early in life it is possible to detect, and possibly cure, the cellular and biochemical changes that characterize this event. This topic is timely and relevant since a variety of clinical and epidemiologic studies strongly suggest that in asthma, remodelling may start very early in life and that current prevention and treatment measures, including early avoidance measures and pharmaceutical interventions, are relatively ineffective in preventing the development of irreversible airway changes or in reverting them, once established. RECENT FINDINGS: Recent findings show that structural changes characterizing remodelling, such as subepithelial basement membrane thickening, epithelial cell disruption, protease/antiprotease imbalance and neoangiogenesis, are detectable in children with asthma and even in children with respiratory symptoms or with atopy, before a clear clinical diagnosis of bronchial asthma is made. SUMMARY: Identification of the early structural changes that may precede the development of asthma and of factors leading to permanent loss of lung function appear central to future asthma management. Wolters Kluwer Health 2007-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4031/1/A_BaenaCagnani_Rossi_Canonica.pdf Baena Cagnani, Carlos E., Rossi, Giovanni A. ORCID: https://orcid.org/0000-0001-7248-9042 <https://orcid.org/0000-0001-7248-9042> and Canonica, Giorgio Walter ORCID: https://orcid.org/0000-0001-8467-2557 <https://orcid.org/0000-0001-8467-2557> (2007) Airway remodelling in children: when does it start? Current Opinion in Allergy and Clinical Immunology, 7 (2). pp. 196-200. info:eu-repo/semantics/altIdentifier/doi/10.1097/ACI.0b013e328082559a
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Baena Cagnani, Carlos E.
Rossi, Giovanni A.
Canonica, Giorgio Walter
Airway remodelling in children: when does it start?
topic_facet R Medicina (General)
description The review characterizes airway remodelling in childhood asthma and describes how early in life it is possible to detect, and possibly cure, the cellular and biochemical changes that characterize this event. This topic is timely and relevant since a variety of clinical and epidemiologic studies strongly suggest that in asthma, remodelling may start very early in life and that current prevention and treatment measures, including early avoidance measures and pharmaceutical interventions, are relatively ineffective in preventing the development of irreversible airway changes or in reverting them, once established. RECENT FINDINGS: Recent findings show that structural changes characterizing remodelling, such as subepithelial basement membrane thickening, epithelial cell disruption, protease/antiprotease imbalance and neoangiogenesis, are detectable in children with asthma and even in children with respiratory symptoms or with atopy, before a clear clinical diagnosis of bronchial asthma is made. SUMMARY: Identification of the early structural changes that may precede the development of asthma and of factors leading to permanent loss of lung function appear central to future asthma management.
format Artículo
author Baena Cagnani, Carlos E.
Rossi, Giovanni A.
Canonica, Giorgio Walter
author_facet Baena Cagnani, Carlos E.
Rossi, Giovanni A.
Canonica, Giorgio Walter
author_sort Baena Cagnani, Carlos E.
title Airway remodelling in children: when does it start?
title_short Airway remodelling in children: when does it start?
title_full Airway remodelling in children: when does it start?
title_fullStr Airway remodelling in children: when does it start?
title_full_unstemmed Airway remodelling in children: when does it start?
title_sort airway remodelling in children: when does it start?
publisher Wolters Kluwer Health
publishDate 2007
url http://pa.bibdigital.ucc.edu.ar/4031/1/A_BaenaCagnani_Rossi_Canonica.pdf
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AT rossigiovannia airwayremodellinginchildrenwhendoesitstart
AT canonicagiorgiowalter airwayremodellinginchildrenwhendoesitstart
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