Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States
Objective: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argenti...
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| Lenguaje: | Español |
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2006
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| Acceso en línea: | http://pa.bibdigital.ucc.edu.ar/4002/1/A_Steinmaus_Bates_Yuan_Kalman_Atallah_Rey_Biggs_Hopenhayn_Moore_Hoang_Smith.pdf |
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I38-R144-40022025-04-14T19:13:23Z http://pa.bibdigital.ucc.edu.ar/4002/ Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States Steinmaus, Craig Bates, Michael N. Yuan, Yan Kalman, Dave Atallah, Raja Rey, Omar A. Biggs, Mary Lou Hopenhayn, Claudia Moore, Lee E. Hoang, Bruce K. Smith, Allan H. R Medicina (General) Objective: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina, the adjusted odds ratio (OR) for subjects with a high proportion of ingested arsenic excreted as monomethylarsonate (%MMA) was 2.17 (95% confidence interval [CI] = 1.02-4.63) in smokers and 0.48 (95% CI = 0.17-1.33) in nonsmokers. In the United States, the adjusted ORs for high %MMA in subjects with arsenic intakes less than and greater than 100 μg/d were 1.20 (95% CI = 0.27-5.38) and 2.70 (95% CI = 0.39-18.6). Conclusions: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer. 2006-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4002/1/A_Steinmaus_Bates_Yuan_Kalman_Atallah_Rey_Biggs_Hopenhayn_Moore_Hoang_Smith.pdf Steinmaus, Craig ORCID: https://orcid.org/0000-0003-2697-843X <https://orcid.org/0000-0003-2697-843X>, Bates, Michael N., Yuan, Yan, Kalman, Dave, Atallah, Raja, Rey, Omar A. ORCID: https://orcid.org/0000-0002-9232-1252 <https://orcid.org/0000-0002-9232-1252>, Biggs, Mary Lou, Hopenhayn, Claudia, Moore, Lee E., Hoang, Bruce K. and Smith, Allan H. (2006) Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. Journal of Occupational and Environmental Medicine, 48 (5). pp. 478-488. ISSN 1076-2752 info:eu-repo/semantics/altIdentifier/doi/10.1097/01.jom.0000200982.28276.70 |
| institution |
Universidad Católica de Córdoba |
| institution_str |
I-38 |
| repository_str |
R-144 |
| collection |
Producción Académica Universidad Católica de Córdoba (UCCor) |
| language |
Español |
| orig_language_str_mv |
spa |
| topic |
R Medicina (General) |
| spellingShingle |
R Medicina (General) Steinmaus, Craig Bates, Michael N. Yuan, Yan Kalman, Dave Atallah, Raja Rey, Omar A. Biggs, Mary Lou Hopenhayn, Claudia Moore, Lee E. Hoang, Bruce K. Smith, Allan H. Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| topic_facet |
R Medicina (General) |
| description |
Objective: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina, the adjusted odds ratio (OR) for subjects with a high proportion of ingested arsenic excreted as monomethylarsonate (%MMA) was 2.17 (95% confidence interval [CI] = 1.02-4.63) in smokers and 0.48 (95% CI = 0.17-1.33) in nonsmokers. In the United States, the adjusted ORs for high %MMA in subjects with arsenic intakes less than and greater than 100 μg/d were 1.20 (95% CI = 0.27-5.38) and 2.70 (95% CI = 0.39-18.6). Conclusions: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer. |
| format |
Artículo |
| author |
Steinmaus, Craig Bates, Michael N. Yuan, Yan Kalman, Dave Atallah, Raja Rey, Omar A. Biggs, Mary Lou Hopenhayn, Claudia Moore, Lee E. Hoang, Bruce K. Smith, Allan H. |
| author_facet |
Steinmaus, Craig Bates, Michael N. Yuan, Yan Kalman, Dave Atallah, Raja Rey, Omar A. Biggs, Mary Lou Hopenhayn, Claudia Moore, Lee E. Hoang, Bruce K. Smith, Allan H. |
| author_sort |
Steinmaus, Craig |
| title |
Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| title_short |
Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| title_full |
Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| title_fullStr |
Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| title_full_unstemmed |
Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States |
| title_sort |
arsenic methylation and bladder cancer risk in case-control studies in argentina and the united states |
| publishDate |
2006 |
| url |
http://pa.bibdigital.ucc.edu.ar/4002/1/A_Steinmaus_Bates_Yuan_Kalman_Atallah_Rey_Biggs_Hopenhayn_Moore_Hoang_Smith.pdf |
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