Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis

Background: Allergen sensitization is an important risk factor for allergic disease, including allergic rhinitis (AR), one of the most common chronic conditions in children. Our objective was to assess the sensitization status of pediatric AR patients. Methods/Data base: Patients from 148 centers in...

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Autores principales: Baena Cagnani, Carlos E., Finn, Albert, Potter, Peter, Meltzer, Eli O., Wahn, Urich, Emeryk, Andrzej, Hardy, Pierre, Ruuth, Erik
Formato: Artículo
Lenguaje:Español
Publicado: 2006
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/4001/1/A_BaenaCagnini_Finn_Potter_Meltzer_Wahn_Emeryk_Hardy_Ruuth.pdf
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Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-4001
record_format dspace
spelling I38-R144-40012025-04-07T20:24:31Z http://pa.bibdigital.ucc.edu.ar/4001/ Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis Baena Cagnani, Carlos E. Finn, Albert Potter, Peter Meltzer, Eli O. Wahn, Urich Emeryk, Andrzej Hardy, Pierre Ruuth, Erik R Medicina (General) Background: Allergen sensitization is an important risk factor for allergic disease, including allergic rhinitis (AR), one of the most common chronic conditions in children. Our objective was to assess the sensitization status of pediatric AR patients. Methods/Data base: Patients from 148 centers in 15 countries were enrolled in a placebo-controlled, randomized, parallel-group study of children aged 6-11 years with seasonal AR (SAR). Children had to have a positive skin prick test to at least one pollen allergen for the current season, confirmed by specific serum immunoglobulin E (IgE) testing. Efficacy analysis was performed on the modified intention-to-treat (mITT) population, who were treated with fexofenadine HCl 30 mg twice daily or placebo. Efficacy across plant categories and for allergen-specific IgE levels was evaluated as the mean change from baseline in the total symptom score (TSS). Results: A concordant positive response to IgE and skin prick test to at least one allergen was observed in 99.6% of children in the mITT population. Analysis by plant category showed that grasses were the most common group of allergens; analysis by country and plant category showed that, in most countries, grasses were the most common group of allergens. Fexofenadine significantly improved the mean change from baseline in TSS in children grouped according to their sensitization to different plant categories and to different serum allergen- specific IgE levels (p < 0.01 for all subgroup tests). Conclusion: This worldwide pediatric study provides useful information about sensitization overall and by individual country analysis. Fexofenadine significantly improved the symptoms of SAR in all groups examined. 2006-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/4001/1/A_BaenaCagnini_Finn_Potter_Meltzer_Wahn_Emeryk_Hardy_Ruuth.pdf Baena Cagnani, Carlos E., Finn, Albert, Potter, Peter, Meltzer, Eli O., Wahn, Urich, Emeryk, Andrzej ORCID: https://orcid.org/0000-0003-1853-8696 <https://orcid.org/0000-0003-1853-8696>, Hardy, Pierre ORCID: https://orcid.org/0000-0002-9846-7113 <https://orcid.org/0000-0002-9846-7113> and Ruuth, Erik ORCID: https://orcid.org/0009-0009-2420-7755 <https://orcid.org/0009-0009-2420-7755> (2006) Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis. Allergy and Clinical Immunology International, 18 (5). pp. 184-191. ISSN 0838-1925 info:eu-repo/semantics/altIdentifier/doi/10.1027/0838-1925.18.5.184
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Baena Cagnani, Carlos E.
Finn, Albert
Potter, Peter
Meltzer, Eli O.
Wahn, Urich
Emeryk, Andrzej
Hardy, Pierre
Ruuth, Erik
Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
topic_facet R Medicina (General)
description Background: Allergen sensitization is an important risk factor for allergic disease, including allergic rhinitis (AR), one of the most common chronic conditions in children. Our objective was to assess the sensitization status of pediatric AR patients. Methods/Data base: Patients from 148 centers in 15 countries were enrolled in a placebo-controlled, randomized, parallel-group study of children aged 6-11 years with seasonal AR (SAR). Children had to have a positive skin prick test to at least one pollen allergen for the current season, confirmed by specific serum immunoglobulin E (IgE) testing. Efficacy analysis was performed on the modified intention-to-treat (mITT) population, who were treated with fexofenadine HCl 30 mg twice daily or placebo. Efficacy across plant categories and for allergen-specific IgE levels was evaluated as the mean change from baseline in the total symptom score (TSS). Results: A concordant positive response to IgE and skin prick test to at least one allergen was observed in 99.6% of children in the mITT population. Analysis by plant category showed that grasses were the most common group of allergens; analysis by country and plant category showed that, in most countries, grasses were the most common group of allergens. Fexofenadine significantly improved the mean change from baseline in TSS in children grouped according to their sensitization to different plant categories and to different serum allergen- specific IgE levels (p < 0.01 for all subgroup tests). Conclusion: This worldwide pediatric study provides useful information about sensitization overall and by individual country analysis. Fexofenadine significantly improved the symptoms of SAR in all groups examined.
format Artículo
author Baena Cagnani, Carlos E.
Finn, Albert
Potter, Peter
Meltzer, Eli O.
Wahn, Urich
Emeryk, Andrzej
Hardy, Pierre
Ruuth, Erik
author_facet Baena Cagnani, Carlos E.
Finn, Albert
Potter, Peter
Meltzer, Eli O.
Wahn, Urich
Emeryk, Andrzej
Hardy, Pierre
Ruuth, Erik
author_sort Baena Cagnani, Carlos E.
title Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
title_short Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
title_full Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
title_fullStr Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
title_full_unstemmed Pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
title_sort pollen aeroallergen sensitizaton in children with seasonal allergic rhinitis
publishDate 2006
url http://pa.bibdigital.ucc.edu.ar/4001/1/A_BaenaCagnini_Finn_Potter_Meltzer_Wahn_Emeryk_Hardy_Ruuth.pdf
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AT finnalbert pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT potterpeter pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT meltzerelio pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT wahnurich pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT emerykandrzej pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT hardypierre pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
AT ruutherik pollenaeroallergensensitizatoninchildrenwithseasonalallergicrhinitis
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