Topiramate prevents excitotoxic damage in the newborn rodent brain

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Brain lesions induced in newborn mice by the glutamatergic agonists ibotenate (acting on NMDA and metabotropic receptors) and S-bromowillardiine (acting on AMPA-kainate receptors) mimic some aspects of white matter cysts and transcortical necrosis observed in human perinatal brain damage. Topiramate...

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Autores principales: Sfaello, Ignacio, Baud, Olivier, Arzimanoglou, Alexis, Gressens, Pierre
Formato: Artículo
Lenguaje:Español
Publicado: 2005
Materias:
R Medicina (General)
Acceso en línea:http://pa.bibdigital.ucc.edu.ar/3987/1/A_Sfaello_Baud_Arzimanoglou_Gressens.pdf
Aporte de:
Producción Académica Universidad Católica de Córdoba (UCCor) de Universidad Católica de Córdoba
id I38-R144-3987
record_format dspace
spelling I38-R144-39872025-04-14T19:13:45Z http://pa.bibdigital.ucc.edu.ar/3987/ Topiramate prevents excitotoxic damage in the newborn rodent brain Sfaello, Ignacio Baud, Olivier Arzimanoglou, Alexis Gressens, Pierre R Medicina (General) Brain lesions induced in newborn mice by the glutamatergic agonists ibotenate (acting on NMDA and metabotropic receptors) and S-bromowillardiine (acting on AMPA-kainate receptors) mimic some aspects of white matter cysts and transcortical necrosis observed in human perinatal brain damage. Topiramate (TPM), already used in children to manage newly diagnosed and refractory epilepsy, has potential neuroprotective effects that may be useful in human perinatal brain lesions. In the excitotoxic newborn mouse model, TPM provided dose-dependent and long-lasting protection of developing white matter and cortical plate against S-bromowillardiine. TPM had no significant effect on ibotenate-induced brain lesions. TPM-induced neuroprotection potentially involved increased survival of pre-oligodendrocytes, decreased neuronal apoptosis, inhibition of microglial activation and astrogliosis, and decreased seizure activity. Diazepam, phenytoin, and carbamazepine had no neuroprotective effect in this model. The present study provides experimental support for the consideration of TPM as a candidate therapy for excitotoxic perinatal brain lesions. 2005-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/closedAccess application/pdf spa http://pa.bibdigital.ucc.edu.ar/3987/1/A_Sfaello_Baud_Arzimanoglou_Gressens.pdf Sfaello, Ignacio, Baud, Olivier ORCID: https://orcid.org/0000-0001-5021-0522 <https://orcid.org/0000-0001-5021-0522>, Arzimanoglou, Alexis ORCID: https://orcid.org/0000-0002-7233-2771 <https://orcid.org/0000-0002-7233-2771> and Gressens, Pierre (2005) Topiramate prevents excitotoxic damage in the newborn rodent brain. Neurobiology of Disease, 20 (3). pp. 837-848. ISSN 0969-9961 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nbd.2005.05.019
institution Universidad Católica de Córdoba
institution_str I-38
repository_str R-144
collection Producción Académica Universidad Católica de Córdoba (UCCor)
language Español
orig_language_str_mv spa
topic R Medicina (General)
spellingShingle R Medicina (General)
Sfaello, Ignacio
Baud, Olivier
Arzimanoglou, Alexis
Gressens, Pierre
Topiramate prevents excitotoxic damage in the newborn rodent brain
topic_facet R Medicina (General)
description Brain lesions induced in newborn mice by the glutamatergic agonists ibotenate (acting on NMDA and metabotropic receptors) and S-bromowillardiine (acting on AMPA-kainate receptors) mimic some aspects of white matter cysts and transcortical necrosis observed in human perinatal brain damage. Topiramate (TPM), already used in children to manage newly diagnosed and refractory epilepsy, has potential neuroprotective effects that may be useful in human perinatal brain lesions. In the excitotoxic newborn mouse model, TPM provided dose-dependent and long-lasting protection of developing white matter and cortical plate against S-bromowillardiine. TPM had no significant effect on ibotenate-induced brain lesions. TPM-induced neuroprotection potentially involved increased survival of pre-oligodendrocytes, decreased neuronal apoptosis, inhibition of microglial activation and astrogliosis, and decreased seizure activity. Diazepam, phenytoin, and carbamazepine had no neuroprotective effect in this model. The present study provides experimental support for the consideration of TPM as a candidate therapy for excitotoxic perinatal brain lesions.
format Artículo
author Sfaello, Ignacio
Baud, Olivier
Arzimanoglou, Alexis
Gressens, Pierre
author_facet Sfaello, Ignacio
Baud, Olivier
Arzimanoglou, Alexis
Gressens, Pierre
author_sort Sfaello, Ignacio
title Topiramate prevents excitotoxic damage in the newborn rodent brain
title_short Topiramate prevents excitotoxic damage in the newborn rodent brain
title_full Topiramate prevents excitotoxic damage in the newborn rodent brain
title_fullStr Topiramate prevents excitotoxic damage in the newborn rodent brain
title_full_unstemmed Topiramate prevents excitotoxic damage in the newborn rodent brain
title_sort topiramate prevents excitotoxic damage in the newborn rodent brain
publishDate 2005
url http://pa.bibdigital.ucc.edu.ar/3987/1/A_Sfaello_Baud_Arzimanoglou_Gressens.pdf
work_keys_str_mv AT sfaelloignacio topiramatepreventsexcitotoxicdamageinthenewbornrodentbrain
AT baudolivier topiramatepreventsexcitotoxicdamageinthenewbornrodentbrain
AT arzimanogloualexis topiramatepreventsexcitotoxicdamageinthenewbornrodentbrain
AT gressenspierre topiramatepreventsexcitotoxicdamageinthenewbornrodentbrain
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